What to Do about Esophageal Varices?
In this issue of the Journal , Burroughs and colleagues report the results of a two-year randomized controlled trial of propranolol therapy to prevent recurrent bleeding from esophageal varices. 1 There was no reduction in the frequency of bleeding from either varices or mucosal erosions despite a s...
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| Veröffentlicht in: | The New England journal of medicine 1983-12, Vol.309 (25), p.1575-1577 |
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| container_issue | 25 |
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| container_title | The New England journal of medicine |
| container_volume | 309 |
| creator | Reynolds, Telfer B |
| description | In this issue of the
Journal
, Burroughs and colleagues report the results of a two-year randomized controlled trial of propranolol therapy to prevent recurrent bleeding from esophageal varices.
1
There was no reduction in the frequency of bleeding from either varices or mucosal erosions despite a substantial reduction in wedged hepatic-vein pressure.
These results are disappointing, to say the least. Compliance by the patients taking propranolol was good, judging from decreases in pulse rate, though it seems possible that the alcoholic patients who had resumed drinking were not taking their medication at the time of the bleeding episodes. Forty-eight patients . . . |
| doi_str_mv | 10.1056/NEJM198312223092510 |
| format | Article |
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Journal
, Burroughs and colleagues report the results of a two-year randomized controlled trial of propranolol therapy to prevent recurrent bleeding from esophageal varices.
1
There was no reduction in the frequency of bleeding from either varices or mucosal erosions despite a substantial reduction in wedged hepatic-vein pressure.
These results are disappointing, to say the least. Compliance by the patients taking propranolol was good, judging from decreases in pulse rate, though it seems possible that the alcoholic patients who had resumed drinking were not taking their medication at the time of the bleeding episodes. Forty-eight patients . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198312223092510</identifier><identifier>PMID: 6361556</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Clinical trials ; Clinical Trials as Topic ; Esophageal and Gastric Varices - therapy ; Esophagus ; Gastroenterology ; Gastrointestinal Hemorrhage - drug therapy ; Hemorrhage ; Hepatology ; Hospitals ; Humans ; Hypertension ; Liver diseases ; Patients ; Propranolol - therapeutic use ; Recurrence ; Sclerosing Solutions - therapeutic use ; Veins & arteries</subject><ispartof>The New England journal of medicine, 1983-12, Vol.309 (25), p.1575-1577</ispartof><rights>Copyright Massachusetts Medical Society Dec 22, 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-ea2690f94e5f4475325535f84b524e7140e01ee08d110056a0ebce7d7c35800d3</citedby><cites>FETCH-LOGICAL-c364t-ea2690f94e5f4475325535f84b524e7140e01ee08d110056a0ebce7d7c35800d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1875893967?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6361556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reynolds, Telfer B</creatorcontrib><title>What to Do about Esophageal Varices?</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this issue of the
Journal
, Burroughs and colleagues report the results of a two-year randomized controlled trial of propranolol therapy to prevent recurrent bleeding from esophageal varices.
1
There was no reduction in the frequency of bleeding from either varices or mucosal erosions despite a substantial reduction in wedged hepatic-vein pressure.
These results are disappointing, to say the least. Compliance by the patients taking propranolol was good, judging from decreases in pulse rate, though it seems possible that the alcoholic patients who had resumed drinking were not taking their medication at the time of the bleeding episodes. Forty-eight patients . . .</description><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Esophageal and Gastric Varices - therapy</subject><subject>Esophagus</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Hemorrhage - drug therapy</subject><subject>Hemorrhage</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Liver diseases</subject><subject>Patients</subject><subject>Propranolol - therapeutic use</subject><subject>Recurrence</subject><subject>Sclerosing Solutions - therapeutic use</subject><subject>Veins & arteries</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kEtLw0AUhQdRaq3-AhECihuJ3nnPrERqfVF142M5TJIbbUk6NZMs_PdGWlyIeDd3cb5zuPcQsk_hlIJUZw-Tu3tqDaeMMQ6WSQobZEgl56kQoDbJEICZVGjLt8lOjHPohwo7IAPFFZVSDcnR67tvkzYklyHxWejaZBLD8t2_oa-SF9_Mcoznu2Sr9FXEvfUekeerydP4Jp0-Xt-OL6ZpzpVoU_RMWSitQFkKoSVnUnJZGpFJJlBTAQgUEUxBKfQPeMAsR13onEsDUPAROV7lLpvw0WFsXT2LOVaVX2DoojNgmGbc9uDhL3AeumbR3-ao0dJYbpXuKb6i8ibE2GDpls2s9s2no-C-G3R_NNi7DtbZXVZj8eNZV9brJyu9rqNb4Lz-N-0LjSJzgw</recordid><startdate>19831222</startdate><enddate>19831222</enddate><creator>Reynolds, Telfer B</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19831222</creationdate><title>What to Do about Esophageal Varices?</title><author>Reynolds, Telfer B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-ea2690f94e5f4475325535f84b524e7140e01ee08d110056a0ebce7d7c35800d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Clinical trials</topic><topic>Clinical Trials as Topic</topic><topic>Esophageal and Gastric Varices - therapy</topic><topic>Esophagus</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Hemorrhage - drug therapy</topic><topic>Hemorrhage</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Liver diseases</topic><topic>Patients</topic><topic>Propranolol - therapeutic use</topic><topic>Recurrence</topic><topic>Sclerosing Solutions - therapeutic use</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reynolds, Telfer B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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Journal
, Burroughs and colleagues report the results of a two-year randomized controlled trial of propranolol therapy to prevent recurrent bleeding from esophageal varices.
1
There was no reduction in the frequency of bleeding from either varices or mucosal erosions despite a substantial reduction in wedged hepatic-vein pressure.
These results are disappointing, to say the least. Compliance by the patients taking propranolol was good, judging from decreases in pulse rate, though it seems possible that the alcoholic patients who had resumed drinking were not taking their medication at the time of the bleeding episodes. Forty-eight patients . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>6361556</pmid><doi>10.1056/NEJM198312223092510</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1983-12, Vol.309 (25), p.1575-1577 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; ProQuest Central UK/Ireland |
| subjects | Clinical trials Clinical Trials as Topic Esophageal and Gastric Varices - therapy Esophagus Gastroenterology Gastrointestinal Hemorrhage - drug therapy Hemorrhage Hepatology Hospitals Humans Hypertension Liver diseases Patients Propranolol - therapeutic use Recurrence Sclerosing Solutions - therapeutic use Veins & arteries |
| title | What to Do about Esophageal Varices? |
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