Superoxide radical production by human leukocytes exposed to immune complexes: Inhibitory action of gold compounds
Superoxide radicals produced by phagocytic cells are considered to be important mediators in the rheumatoid inflammation. The effect of the gold compounds auranofin (AF) and gold sodium thiomalate (GST) on superoxide production by human leukocytes was investigated in two models of immunologic injury...
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| Veröffentlicht in: | Inflammation 1983-12, Vol.7 (4), p.355-362 |
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| container_end_page | 362 |
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| container_issue | 4 |
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| container_title | Inflammation |
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| creator | ROISMAN, F. R WALZ, D. T FINKELSTEIN, A. E |
| description | Superoxide radicals produced by phagocytic cells are considered to be important mediators in the rheumatoid inflammation. The effect of the gold compounds auranofin (AF) and gold sodium thiomalate (GST) on superoxide production by human leukocytes was investigated in two models of immunologic injury: immune-complex phagocytosis and frustrated phagocytosis. In both systems, AF (0.5-1.0 micrograms Au/ml) showed a potent inhibitory activity on superoxide generation, quantitated by ferricytochrome c and NBT reduction. GST showed only modest inhibition at higher concentrations (100 microM). The thiol protecting agent dithiothreitol, 1 mM, completely blocks the inhibitory effect of AF. The inhibition of the oxy radical generation by AF may play an important role in the control of rheumatoid inflammation; it is suggested that this action might be mediated through sulfhydryl-AF interaction at the cellular membrane level. |
| doi_str_mv | 10.1007/BF00916300 |
| format | Article |
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The inhibition of the oxy radical generation by AF may play an important role in the control of rheumatoid inflammation; it is suggested that this action might be mediated through sulfhydryl-AF interaction at the cellular membrane level.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/BF00916300</identifier><identifier>PMID: 6317558</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Anti-Inflammatory Agents - pharmacology ; Antigen-Antibody Complex - physiology ; Auranofin ; Aurothioglucose - analogs & derivatives ; Aurothioglucose - pharmacology ; Biological and medical sciences ; Cytochrome c Group ; Dithiothreitol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gold Sodium Thiomalate - pharmacology ; Humans ; Immunobiology ; Leukocytes - drug effects ; Leukocytes - immunology ; Modulation of the immune response (stimulation, suppression) ; Nitroblue Tetrazolium ; Phagocytosis - drug effects ; Superoxides - blood</subject><ispartof>Inflammation, 1983-12, Vol.7 (4), p.355-362</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c301t-be80e5daa4d5db647b57098dbe90fce618759245724e0bbc89f0cc3df97897073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9551207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6317558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROISMAN, F. R</creatorcontrib><creatorcontrib>WALZ, D. T</creatorcontrib><creatorcontrib>FINKELSTEIN, A. E</creatorcontrib><title>Superoxide radical production by human leukocytes exposed to immune complexes: Inhibitory action of gold compounds</title><title>Inflammation</title><addtitle>Inflammation</addtitle><description>Superoxide radicals produced by phagocytic cells are considered to be important mediators in the rheumatoid inflammation. The effect of the gold compounds auranofin (AF) and gold sodium thiomalate (GST) on superoxide production by human leukocytes was investigated in two models of immunologic injury: immune-complex phagocytosis and frustrated phagocytosis. In both systems, AF (0.5-1.0 micrograms Au/ml) showed a potent inhibitory activity on superoxide generation, quantitated by ferricytochrome c and NBT reduction. GST showed only modest inhibition at higher concentrations (100 microM). The thiol protecting agent dithiothreitol, 1 mM, completely blocks the inhibitory effect of AF. The inhibition of the oxy radical generation by AF may play an important role in the control of rheumatoid inflammation; it is suggested that this action might be mediated through sulfhydryl-AF interaction at the cellular membrane level.</description><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antigen-Antibody Complex - physiology</subject><subject>Auranofin</subject><subject>Aurothioglucose - analogs & derivatives</subject><subject>Aurothioglucose - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cytochrome c Group</subject><subject>Dithiothreitol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gold Sodium Thiomalate - pharmacology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - immunology</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Nitroblue Tetrazolium</subject><subject>Phagocytosis - drug effects</subject><subject>Superoxides - blood</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAYhK2qFSzQS-9IPlQ9IKW8Xsex3RtF5UNC4tByjvzxprgkcbBjafffN2VX9MhpDvNopJkh5BODrwxAnn-_AtCs4QDvyIoJyau1kM17sgLeQMW1lofkKOc_AKC04gfkoOFMCqFWJP0sE6a4CR5pMj4409MpRV_cHOJI7ZY-lsGMtMfyFN12xkxxM8WMns6RhmEoI1IXh6nHDeZv9HZ8DDbMMW2p2UXEjv6OvX-BYhl9PiEfOtNn_LjXY_Jw9ePX5U11d399e3lxVzkObK4sKkDhjam98LappRUStPIWNXQOG6ak0OtayHWNYK1TugPnuO-0VFqC5Mfkyy536fNcMM_tELLDvjcjxpJbBQq05M2bIKsZcNHoBTzbgS7FnBN27ZTCYNK2ZdD-e6L9_8QCn-5Tix3Qv6L76Rf_8943eVm9S2Z0Ib9iWgi2Xlr8BXJ5kcQ</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>ROISMAN, F. 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E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-be80e5daa4d5db647b57098dbe90fce618759245724e0bbc89f0cc3df97897073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antigen-Antibody Complex - physiology</topic><topic>Auranofin</topic><topic>Aurothioglucose - analogs & derivatives</topic><topic>Aurothioglucose - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cytochrome c Group</topic><topic>Dithiothreitol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gold Sodium Thiomalate - pharmacology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - immunology</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Nitroblue Tetrazolium</topic><topic>Phagocytosis - drug effects</topic><topic>Superoxides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROISMAN, F. R</creatorcontrib><creatorcontrib>WALZ, D. T</creatorcontrib><creatorcontrib>FINKELSTEIN, A. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superoxide radical production by human leukocytes exposed to immune complexes: Inhibitory action of gold compounds</atitle><jtitle>Inflammation</jtitle><addtitle>Inflammation</addtitle><date>1983-12</date><risdate>1983</risdate><volume>7</volume><issue>4</issue><spage>355</spage><epage>362</epage><pages>355-362</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Superoxide radicals produced by phagocytic cells are considered to be important mediators in the rheumatoid inflammation. The effect of the gold compounds auranofin (AF) and gold sodium thiomalate (GST) on superoxide production by human leukocytes was investigated in two models of immunologic injury: immune-complex phagocytosis and frustrated phagocytosis. In both systems, AF (0.5-1.0 micrograms Au/ml) showed a potent inhibitory activity on superoxide generation, quantitated by ferricytochrome c and NBT reduction. GST showed only modest inhibition at higher concentrations (100 microM). The thiol protecting agent dithiothreitol, 1 mM, completely blocks the inhibitory effect of AF. The inhibition of the oxy radical generation by AF may play an important role in the control of rheumatoid inflammation; it is suggested that this action might be mediated through sulfhydryl-AF interaction at the cellular membrane level.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>6317558</pmid><doi>10.1007/BF00916300</doi><tpages>8</tpages></addata></record> |
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| ispartof | Inflammation, 1983-12, Vol.7 (4), p.355-362 |
| issn | 0360-3997 1573-2576 |
| language | eng |
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| subjects | Anti-Inflammatory Agents - pharmacology Antigen-Antibody Complex - physiology Auranofin Aurothioglucose - analogs & derivatives Aurothioglucose - pharmacology Biological and medical sciences Cytochrome c Group Dithiothreitol - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Gold Sodium Thiomalate - pharmacology Humans Immunobiology Leukocytes - drug effects Leukocytes - immunology Modulation of the immune response (stimulation, suppression) Nitroblue Tetrazolium Phagocytosis - drug effects Superoxides - blood |
| title | Superoxide radical production by human leukocytes exposed to immune complexes: Inhibitory action of gold compounds |
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