Antihypertensive polar and neutral renopapillary lipids. Which is a hormone?
Two antihypertensive lipids can be derived from the renal papilla, the antihypertensive polar (APRL) and the antihypertensive neutral (ANRL) renomedullary lipid. The renal venous effluent of the unclipped kidney contains both ANRL and APRL. This effluent lowers the arterial pressure (AP) of the norm...
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Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1983-11, Vol.5 (6 Pt 3), p.V61-V65 |
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creator | Muirhead, E E Byers, L W Folkow, B Göthberg, G Thorén, P Brooks, B |
description | Two antihypertensive lipids can be derived from the renal papilla, the antihypertensive polar (APRL) and the antihypertensive neutral (ANRL) renomedullary lipid. The renal venous effluent of the unclipped kidney contains both ANRL and APRL. This effluent lowers the arterial pressure (AP) of the normal rat when infused i.v. As it lowers the AP the heart rate (HR) and sympathetic nerve activity (SNA) are depressed. ANRL infused i.v. also lowers HR and SNA as it depresses the AP. Conversely, APRL elevates HR and SNA as it lowers the AP. Thus, of the two lipids in the renal venous effluent after unclipping, ANRL appears to be dominant. APRL, however, in the renal venous effluent could potentiate the action of ANRL. The net effect of these observations is to support the view that ANRL is an antihypertensive hormone liberated by the kidney after unclipping. The renomedullary interstitial cells (RIC) degranulate after unclipping. ANRL can be derived from these cells. Thus, the RIC, cells known to exert an endocrine-type antihypertensive function, may well be the source of ANRL in the renal venous effluent after unclipping. The hormonal action of ANRL appears as a major cause of the lowering of the AP after unclipping. It is not known what factors modulate the RIC endocrine system. There is a suggestion that angiotensin may be one of these factors based on the ineffectiveness of these cells toward retarding hypertension when the circulating plasma angiotensin level is high, and their effectiveness when the circulating plasma angiotensin level is low. |
doi_str_mv | 10.1161/01.HYP.5.6_Pt_3.V61 |
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Which is a hormone?</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Muirhead, E E ; Byers, L W ; Folkow, B ; Göthberg, G ; Thorén, P ; Brooks, B</creator><creatorcontrib>Muirhead, E E ; Byers, L W ; Folkow, B ; Göthberg, G ; Thorén, P ; Brooks, B</creatorcontrib><description>Two antihypertensive lipids can be derived from the renal papilla, the antihypertensive polar (APRL) and the antihypertensive neutral (ANRL) renomedullary lipid. The renal venous effluent of the unclipped kidney contains both ANRL and APRL. This effluent lowers the arterial pressure (AP) of the normal rat when infused i.v. As it lowers the AP the heart rate (HR) and sympathetic nerve activity (SNA) are depressed. ANRL infused i.v. also lowers HR and SNA as it depresses the AP. Conversely, APRL elevates HR and SNA as it lowers the AP. Thus, of the two lipids in the renal venous effluent after unclipping, ANRL appears to be dominant. APRL, however, in the renal venous effluent could potentiate the action of ANRL. The net effect of these observations is to support the view that ANRL is an antihypertensive hormone liberated by the kidney after unclipping. The renomedullary interstitial cells (RIC) degranulate after unclipping. ANRL can be derived from these cells. Thus, the RIC, cells known to exert an endocrine-type antihypertensive function, may well be the source of ANRL in the renal venous effluent after unclipping. The hormonal action of ANRL appears as a major cause of the lowering of the AP after unclipping. It is not known what factors modulate the RIC endocrine system. There is a suggestion that angiotensin may be one of these factors based on the ineffectiveness of these cells toward retarding hypertension when the circulating plasma angiotensin level is high, and their effectiveness when the circulating plasma angiotensin level is low.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.5.6_Pt_3.V61</identifier><identifier>PMID: 6654466</identifier><language>eng</language><publisher>United States</publisher><subject>Angiotensins - blood ; Animals ; Antihypertensive Agents - administration & dosage ; Blood Pressure ; Cells, Cultured ; Dose-Response Relationship, Drug ; Heart Rate ; Hormones ; Hypertension - drug therapy ; Hypertension, Renovascular - blood ; Hypertension, Renovascular - physiopathology ; Kidney Medulla - analysis ; Kidney Medulla - cytology ; Kidney Medulla - physiology ; Lipids - isolation & purification ; Lipids - pharmacology ; Lipids - physiology ; Rats ; Renin-Angiotensin System ; Sympathetic Nervous System - physiopathology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1983-11, Vol.5 (6 Pt 3), p.V61-V65</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-45223f3ce96f230098c06311d1ff783fc114c25fffb8478a2a01c13eec2cef653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6654466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muirhead, E E</creatorcontrib><creatorcontrib>Byers, L W</creatorcontrib><creatorcontrib>Folkow, B</creatorcontrib><creatorcontrib>Göthberg, G</creatorcontrib><creatorcontrib>Thorén, P</creatorcontrib><creatorcontrib>Brooks, B</creatorcontrib><title>Antihypertensive polar and neutral renopapillary lipids. Which is a hormone?</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Two antihypertensive lipids can be derived from the renal papilla, the antihypertensive polar (APRL) and the antihypertensive neutral (ANRL) renomedullary lipid. The renal venous effluent of the unclipped kidney contains both ANRL and APRL. This effluent lowers the arterial pressure (AP) of the normal rat when infused i.v. As it lowers the AP the heart rate (HR) and sympathetic nerve activity (SNA) are depressed. ANRL infused i.v. also lowers HR and SNA as it depresses the AP. Conversely, APRL elevates HR and SNA as it lowers the AP. Thus, of the two lipids in the renal venous effluent after unclipping, ANRL appears to be dominant. APRL, however, in the renal venous effluent could potentiate the action of ANRL. The net effect of these observations is to support the view that ANRL is an antihypertensive hormone liberated by the kidney after unclipping. The renomedullary interstitial cells (RIC) degranulate after unclipping. ANRL can be derived from these cells. Thus, the RIC, cells known to exert an endocrine-type antihypertensive function, may well be the source of ANRL in the renal venous effluent after unclipping. The hormonal action of ANRL appears as a major cause of the lowering of the AP after unclipping. It is not known what factors modulate the RIC endocrine system. There is a suggestion that angiotensin may be one of these factors based on the ineffectiveness of these cells toward retarding hypertension when the circulating plasma angiotensin level is high, and their effectiveness when the circulating plasma angiotensin level is low.</description><subject>Angiotensins - blood</subject><subject>Animals</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Blood Pressure</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>Heart Rate</subject><subject>Hormones</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension, Renovascular - blood</subject><subject>Hypertension, Renovascular - physiopathology</subject><subject>Kidney Medulla - analysis</subject><subject>Kidney Medulla - cytology</subject><subject>Kidney Medulla - physiology</subject><subject>Lipids - isolation & purification</subject><subject>Lipids - pharmacology</subject><subject>Lipids - physiology</subject><subject>Rats</subject><subject>Renin-Angiotensin System</subject><subject>Sympathetic Nervous System - physiopathology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LwzAYx4Moc04_gQg5eWvNk7e1JxmiThi4g6-nkKUJjXRtTVph397Ihqfn8H_h__wQugSSA0i4IZAvP9e5yKVaD4rlbxKO0BQE5RkXkh2jKYGSZyXAxyk6i_GLEOCczydoIqXgXMopWi3awde73obBttH_WNx3jQ5YtxVu7TgE3eBg267XvW-SsMON730Vc_xee1NjH7HGdRe2XWtvz9GJ0020F4c7Q68P9y93y2z1_Ph0t1hlhnExpHGUMseMLaWjjJCyMEQygAqcmxfMGQBuqHDObQo-LzTVBAwwaw011knBZuh639uH7nu0cVBbH41N-1rbjVEVpCAlLSAZ2d5oQhdjsE71wW_TFwqI-mOoCKjEUAm1Z6gSw5S6OtSPm62t_jMHaOwXAshvFQ</recordid><startdate>198311</startdate><enddate>198311</enddate><creator>Muirhead, E E</creator><creator>Byers, L W</creator><creator>Folkow, B</creator><creator>Göthberg, G</creator><creator>Thorén, P</creator><creator>Brooks, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198311</creationdate><title>Antihypertensive polar and neutral renopapillary lipids. Which is a hormone?</title><author>Muirhead, E E ; Byers, L W ; Folkow, B ; Göthberg, G ; Thorén, P ; Brooks, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-45223f3ce96f230098c06311d1ff783fc114c25fffb8478a2a01c13eec2cef653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Angiotensins - blood</topic><topic>Animals</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Blood Pressure</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>Heart Rate</topic><topic>Hormones</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension, Renovascular - blood</topic><topic>Hypertension, Renovascular - physiopathology</topic><topic>Kidney Medulla - analysis</topic><topic>Kidney Medulla - cytology</topic><topic>Kidney Medulla - physiology</topic><topic>Lipids - isolation & purification</topic><topic>Lipids - pharmacology</topic><topic>Lipids - physiology</topic><topic>Rats</topic><topic>Renin-Angiotensin System</topic><topic>Sympathetic Nervous System - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muirhead, E E</creatorcontrib><creatorcontrib>Byers, L W</creatorcontrib><creatorcontrib>Folkow, B</creatorcontrib><creatorcontrib>Göthberg, G</creatorcontrib><creatorcontrib>Thorén, P</creatorcontrib><creatorcontrib>Brooks, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muirhead, E E</au><au>Byers, L W</au><au>Folkow, B</au><au>Göthberg, G</au><au>Thorén, P</au><au>Brooks, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihypertensive polar and neutral renopapillary lipids. Which is a hormone?</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1983-11</date><risdate>1983</risdate><volume>5</volume><issue>6 Pt 3</issue><spage>V61</spage><epage>V65</epage><pages>V61-V65</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><abstract>Two antihypertensive lipids can be derived from the renal papilla, the antihypertensive polar (APRL) and the antihypertensive neutral (ANRL) renomedullary lipid. The renal venous effluent of the unclipped kidney contains both ANRL and APRL. This effluent lowers the arterial pressure (AP) of the normal rat when infused i.v. As it lowers the AP the heart rate (HR) and sympathetic nerve activity (SNA) are depressed. ANRL infused i.v. also lowers HR and SNA as it depresses the AP. Conversely, APRL elevates HR and SNA as it lowers the AP. Thus, of the two lipids in the renal venous effluent after unclipping, ANRL appears to be dominant. APRL, however, in the renal venous effluent could potentiate the action of ANRL. The net effect of these observations is to support the view that ANRL is an antihypertensive hormone liberated by the kidney after unclipping. The renomedullary interstitial cells (RIC) degranulate after unclipping. ANRL can be derived from these cells. Thus, the RIC, cells known to exert an endocrine-type antihypertensive function, may well be the source of ANRL in the renal venous effluent after unclipping. The hormonal action of ANRL appears as a major cause of the lowering of the AP after unclipping. It is not known what factors modulate the RIC endocrine system. There is a suggestion that angiotensin may be one of these factors based on the ineffectiveness of these cells toward retarding hypertension when the circulating plasma angiotensin level is high, and their effectiveness when the circulating plasma angiotensin level is low.</abstract><cop>United States</cop><pmid>6654466</pmid><doi>10.1161/01.HYP.5.6_Pt_3.V61</doi><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
subjects | Angiotensins - blood Animals Antihypertensive Agents - administration & dosage Blood Pressure Cells, Cultured Dose-Response Relationship, Drug Heart Rate Hormones Hypertension - drug therapy Hypertension, Renovascular - blood Hypertension, Renovascular - physiopathology Kidney Medulla - analysis Kidney Medulla - cytology Kidney Medulla - physiology Lipids - isolation & purification Lipids - pharmacology Lipids - physiology Rats Renin-Angiotensin System Sympathetic Nervous System - physiopathology |
title | Antihypertensive polar and neutral renopapillary lipids. Which is a hormone? |
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