Vascular α-adrenergic blocking properties of quinidine
The specificity of the α-adrenergic vascular blockade by quinidine was tested in the inatct dog, in rabbit isolated aortic strips, and in rats under ganglionic blockade. Quinidine did not affect the pressor response of angiotensin II in dogs, the contractile response of histamine nor angiotensin II...
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| Veröffentlicht in: | European journal of pharmacology 1983-10, Vol.94 (3), p.185-192 |
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| creator | Caldwell, Robert W. Elam, Janet T. Mecca, Thomas E. Nash, Clinton B. |
| description | The specificity of the α-adrenergic vascular blockade by quinidine was tested in the inatct dog, in rabbit isolated aortic strips, and in rats under ganglionic blockade. Quinidine did not affect the pressor response of angiotensin II in dogs, the contractile response of histamine nor angiotensin II in aortic strips, nor the dose-pressor response curve of the α-agonist, B-HT 933 in the rat. However, the pressor effect of adrenaline and noradrenaline (NA) were significantly reduced in dogs, and the dose-response curves to NA in aortic strips and to the α-agonist, phenylphrine in rats was shifted to the right in a parallel manner by quinidine. In the rat, quinidine is at least 14 times more potent in antagonizing the vasopressor effect of an α
1-vs. and α
2-adrenoceptor agonist. |
| doi_str_mv | 10.1016/0014-2999(83)90407-7 |
| format | Article |
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1-vs. and α
2-adrenoceptor agonist.</description><subject>Adrenergic alpha-Antagonists</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Azepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Dogs</subject><subject>Female</subject><subject>Ganglionic-blocked rat</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>Histamine - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Norepinephrine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - pharmacology</subject><subject>Quinidine</subject><subject>Quinidine - pharmacology</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vasoconstriction - drug effects</subject><subject>α 1-vs. α 2-Adrenergic blockade</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRaq2-gUIWIrqInslkbhtBijcouFG3w2RyUkbTpM4kgo_li_hMprZ06eos_u8c_vMRckzhkgIVVwA0TzOt9bliFxpykKncIWOqpE5B0myXjLfIPjmI8Q0AuM74iIwEzYFKNiby1UbX1zYkP9-pLQM2GObeJUXdunffzJNlaJcYOo8xaavko_eNL32Dh2SvsnXEo82ckJe72-fpQzp7un-c3sxSx5To0kIVkoKEgpfaMcFzV2grAGSeFRY511WmtCwYc1ZKKxwooTXjpXWCYyaATcjZ-u7Q46PH2JmFjw7r2jbY9tEoUCBFrgYwX4MutDEGrMwy-IUNX4aCWfkyKxlmJcMoZv58GTmsnWzu98UCy-3SRtCQn27ywZOtq2Ab5-MW08MLXPEBu15jOLj49BhMdB4bh6UP6DpTtv7_Hr8fmIXy</recordid><startdate>19831028</startdate><enddate>19831028</enddate><creator>Caldwell, Robert W.</creator><creator>Elam, Janet T.</creator><creator>Mecca, Thomas E.</creator><creator>Nash, Clinton B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19831028</creationdate><title>Vascular α-adrenergic blocking properties of quinidine</title><author>Caldwell, Robert W. ; Elam, Janet T. ; Mecca, Thomas E. ; Nash, Clinton B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b8b71070b5d9c3654cb9a600742bae559f2897b33ca77a6c0869935dac65e2603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adrenergic alpha-Antagonists</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Azepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Dogs</topic><topic>Female</topic><topic>Ganglionic-blocked rat</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>Histamine - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Norepinephrine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - pharmacology</topic><topic>Quinidine</topic><topic>Quinidine - pharmacology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vasoconstriction - drug effects</topic><topic>α 1-vs. α 2-Adrenergic blockade</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caldwell, Robert W.</creatorcontrib><creatorcontrib>Elam, Janet T.</creatorcontrib><creatorcontrib>Mecca, Thomas E.</creatorcontrib><creatorcontrib>Nash, Clinton B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caldwell, Robert W.</au><au>Elam, Janet T.</au><au>Mecca, Thomas E.</au><au>Nash, Clinton B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular α-adrenergic blocking properties of quinidine</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1983-10-28</date><risdate>1983</risdate><volume>94</volume><issue>3</issue><spage>185</spage><epage>192</epage><pages>185-192</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The specificity of the α-adrenergic vascular blockade by quinidine was tested in the inatct dog, in rabbit isolated aortic strips, and in rats under ganglionic blockade. Quinidine did not affect the pressor response of angiotensin II in dogs, the contractile response of histamine nor angiotensin II in aortic strips, nor the dose-pressor response curve of the α-agonist, B-HT 933 in the rat. However, the pressor effect of adrenaline and noradrenaline (NA) were significantly reduced in dogs, and the dose-response curves to NA in aortic strips and to the α-agonist, phenylphrine in rats was shifted to the right in a parallel manner by quinidine. In the rat, quinidine is at least 14 times more potent in antagonizing the vasopressor effect of an α
1-vs. and α
2-adrenoceptor agonist.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>6140173</pmid><doi>10.1016/0014-2999(83)90407-7</doi><tpages>8</tpages></addata></record> |
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| subjects | Adrenergic alpha-Antagonists Angiotensin II - pharmacology Animals Aorta, Thoracic - drug effects Azepines - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Dogs Female Ganglionic-blocked rat Hexamethonium Compounds - pharmacology Histamine - pharmacology In Vitro Techniques Male Medical sciences Miscellaneous Muscle, Smooth, Vascular - drug effects Norepinephrine - pharmacology Pharmacology. Drug treatments Phenylephrine - pharmacology Quinidine Quinidine - pharmacology Rabbits Rats Rats, Inbred Strains Vasoconstriction - drug effects α 1-vs. α 2-Adrenergic blockade |
| title | Vascular α-adrenergic blocking properties of quinidine |
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