Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase

Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the biosynthesis of leukotrienes with the activity of slow reacting substance of anaphylaxis. Cirsiliol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone) was most potent, and the enzyme partial...

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Veröffentlicht in:	Biochemical and biophysical research communications 1983-10, Vol.116 (2), p.612-618
Hauptverfasser:	Yoshimoto, Tanihiro, Furukawa, Masayuki, Yamamoto, Shozo, Horie, Tokunaru, Watanabe-Kohno, Shigekatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arachidonate 5-lipoxygenase Arachidonate Lipoxygenases Blood Platelets - enzymology Cattle Dose-Response Relationship, Drug Flavones flavonoids Flavonoids - pharmacology Guinea Pigs leukemia leukocytes Leukocytes - enzymology Lipoxygenase Inhibitors Lung - drug effects Male Muscle Contraction - drug effects pigs platelets rats SRS-A - metabolism Swine
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