Anaphylaxis in guinea pigs challenged with antivenin preparations
Affinity chromatography using acrylamide gel was employed to isolate and purify antibodies to the venom of the eastern diamondback rattlesnake, Crotalus adamanteus . The present report treats studies done on guinea pigs rather than mice or rabbits, that demonstrates the non-sensitizing properties of...
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| Veröffentlicht in: | Toxicon (Oxford) 1983, Vol.21 (5), p.729-730 |
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| container_title | Toxicon (Oxford) |
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| creator | Jeter, W.S. Russell, F.E. Sullivan, J.B. |
| description | Affinity chromatography using acrylamide gel was employed to isolate and purify antibodies to the venom of the eastern diamondback rattlesnake, Crotalus adamanteus . The present report treats studies done on guinea pigs rather than mice or rabbits, that demonstrates the non-sensitizing properties of the new antivenin. Two sensitized animals and two uninoculated controls were given horse serum. Both sensitized guinea pigs died within 2-3 min, with the classical signs of anaphylaxis. The two control animals were unaffected. Four sensitized animals were given Wyeth antivenin. Three of the four guinea pigs were unaffected. This study indicates the relative safety of the new SR antivenin. The allergenicity of the purified globulin appears markedly reduced by the purification process. |
| doi_str_mv | 10.1016/0041-0101(83)90278-7 |
| format | Article |
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The allergenicity of the purified globulin appears markedly reduced by the purification process.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(83)90278-7</identifier><identifier>PMID: 6648986</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anaphylaxis - prevention & control ; Animals ; Antivenins - immunology ; Antivenins - standards ; Biological and medical sciences ; Crotalid Venoms - immunology ; Crotalus adamanteus ; Experimental and animal immunopathology. 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The present report treats studies done on guinea pigs rather than mice or rabbits, that demonstrates the non-sensitizing properties of the new antivenin. Two sensitized animals and two uninoculated controls were given horse serum. Both sensitized guinea pigs died within 2-3 min, with the classical signs of anaphylaxis. The two control animals were unaffected. Four sensitized animals were given Wyeth antivenin. Three of the four guinea pigs were unaffected. This study indicates the relative safety of the new SR antivenin. The allergenicity of the purified globulin appears markedly reduced by the purification process.</description><subject>Anaphylaxis - prevention & control</subject><subject>Animals</subject><subject>Antivenins - immunology</subject><subject>Antivenins - standards</subject><subject>Biological and medical sciences</subject><subject>Crotalid Venoms - immunology</subject><subject>Crotalus adamanteus</subject><subject>Experimental and animal immunopathology. Animal models</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJSLdp_0ELPoTSHNyOLFsfl8IS2iQQyKU9i7E03lXxyo7kTZp_X2932WNymoF55uXlYewjh68cuPwGUPMS5vWLFpcGKqVL9YYtuFamFLyBE7Y4Im_Zu5z_AIDQRp6xMylrbbRcsOUy4rh-7vFvyEWIxWobImExhlUu3Br7nuKKfPEUpnWBcQqPFGdqTDRiwikMMb9npx32mT4c5jn7_fPHr6ub8u7--vZqeVc6IaqpJPLOqVq5WjsvuVNzxaZTFQcPdevaxghjPHYkcW5ppHac6041LbbCV6jEOfu8zx3T8LClPNlNyI76HiMN22w1aAAtxKsgF6oyTc1nsN6DLg05J-rsmMIG07PlYHeK7c6f3fmzWtj_iu2uyKdD_rbdkD8-HZzO94vDHbPDvksYXchHzDRVJTXM2Pc9RrO0x0DJZhcoOvIhkZusH8LLPf4BScuXJg</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Jeter, W.S.</creator><creator>Russell, F.E.</creator><creator>Sullivan, J.B.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Anaphylaxis in guinea pigs challenged with antivenin preparations</title><author>Jeter, W.S. ; Russell, F.E. ; Sullivan, J.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-eedcc747c48cd61c73155f7210d04bcb59399dafe6a003968c118f75bab3d2a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Anaphylaxis - prevention & control</topic><topic>Animals</topic><topic>Antivenins - immunology</topic><topic>Antivenins - standards</topic><topic>Biological and medical sciences</topic><topic>Crotalid Venoms - immunology</topic><topic>Crotalus adamanteus</topic><topic>Experimental and animal immunopathology. Animal models</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeter, W.S.</creatorcontrib><creatorcontrib>Russell, F.E.</creatorcontrib><creatorcontrib>Sullivan, J.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeter, W.S.</au><au>Russell, F.E.</au><au>Sullivan, J.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaphylaxis in guinea pigs challenged with antivenin preparations</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1983</date><risdate>1983</risdate><volume>21</volume><issue>5</issue><spage>729</spage><epage>730</epage><pages>729-730</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Affinity chromatography using acrylamide gel was employed to isolate and purify antibodies to the venom of the eastern diamondback rattlesnake, Crotalus adamanteus . 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| fulltext | fulltext |
| identifier | ISSN: 0041-0101 |
| ispartof | Toxicon (Oxford), 1983, Vol.21 (5), p.729-730 |
| issn | 0041-0101 1879-3150 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80800833 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anaphylaxis - prevention & control Animals Antivenins - immunology Antivenins - standards Biological and medical sciences Crotalid Venoms - immunology Crotalus adamanteus Experimental and animal immunopathology. Animal models Female Guinea Pigs Immunopathology Male Medical sciences |
| title | Anaphylaxis in guinea pigs challenged with antivenin preparations |
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