Reaction of Human Immunoglobulin G against K. pneumoniae in the Presence of Complement
The bacteriolytic action of human immunoglobulin G (IgG) and its modifications (pepsin-treated and sulfonated IgG) in the presence of complement was examined with K. pneumoniae and S. aureus. Lysis of K. pneumoniae was observed when concentrated IgG was added, while that of S. arueus was not. This l...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1983/08/25, Vol.31(8), pp.2751-2755 |
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| container_issue | 8 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 31 |
| creator | HIRAHARA, KEIZO KUWAE, TOYOYASU KURATA, MUNETSUGU MATSUISHI, TETSURO SUZUKI, NOBUO |
| description | The bacteriolytic action of human immunoglobulin G (IgG) and its modifications (pepsin-treated and sulfonated IgG) in the presence of complement was examined with K. pneumoniae and S. aureus. Lysis of K. pneumoniae was observed when concentrated IgG was added, while that of S. arueus was not. This lytic action against K. pneumoniae was unaffected by the above modifications of IgG. The results raise the possibility that IgG antibody an high concentration causes the lysis of K. penumoniae by activating the alternative pathway of the complement system and that such activation requires antibody specific to K. pneumonia. |
| doi_str_mv | 10.1248/cpb.31.2751 |
| format | Article |
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Lysis of K. pneumoniae was observed when concentrated IgG was added, while that of S. arueus was not. This lytic action against K. pneumoniae was unaffected by the above modifications of IgG. The results raise the possibility that IgG antibody an high concentration causes the lysis of K. penumoniae by activating the alternative pathway of the complement system and that such activation requires antibody specific to K. pneumonia.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.31.2751</identifier><identifier>PMID: 6360395</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Agglutination Tests ; Bacteriology ; Biological and medical sciences ; Complement System Proteins - immunology ; concentrated IgG ; Fundamental and applied biological sciences. 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Pharm. Bull.</addtitle><description>The bacteriolytic action of human immunoglobulin G (IgG) and its modifications (pepsin-treated and sulfonated IgG) in the presence of complement was examined with K. pneumoniae and S. aureus. Lysis of K. pneumoniae was observed when concentrated IgG was added, while that of S. arueus was not. This lytic action against K. pneumoniae was unaffected by the above modifications of IgG. The results raise the possibility that IgG antibody an high concentration causes the lysis of K. penumoniae by activating the alternative pathway of the complement system and that such activation requires antibody specific to K. pneumonia.</description><subject>Agglutination Tests</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Complement System Proteins - immunology</subject><subject>concentrated IgG</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Klebsiella pneumoniae - immunology</subject><subject>Microbiology</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMGL1DAUh4O4rOPqybNQULxIxyQvbZqjjLq7uLAi6jW8Zl5nO7RJTdqD__22TBlhLwnh-_J-jx9jbwTfCqmqT26otyC2UhfiGdsIUDovpITnbMM5N7mEEl6wlykdOZcF13DJLksoOZhiw_78JHRjG3wWmuxm6tFnt30_-XDoQj11rc-uMzxg69OYfd9mg6epD75FymY0PlD2I1Ii72j5vwv90FFPfnzFLhrsEr1e7yv2-9vXX7ub_O7--nb3-S53hYExp0YYh1JrpaVRAPPbSXQcVOF002iHUO_JSCc5ktJa72tXK14pqDUhOLhiH05zhxj-TpRG27fJUdehpzAlW3FtNNdiFt89EY9hin7ezQpVGKNUqavZ-niyXAwpRWrsENse4z8ruF26tnPXFoRdup7tt-vMqe5pf3bXcmf-fuWYHHZNRO_adNZMUUoData-nLRjGvFAZ45xbF1HS6QwRbXErseS_h8_YLTk4RGe_J3y</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>HIRAHARA, KEIZO</creator><creator>KUWAE, TOYOYASU</creator><creator>KURATA, MUNETSUGU</creator><creator>MATSUISHI, TETSURO</creator><creator>SUZUKI, NOBUO</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Reaction of Human Immunoglobulin G against K. pneumoniae in the Presence of Complement</title><author>HIRAHARA, KEIZO ; KUWAE, TOYOYASU ; KURATA, MUNETSUGU ; MATSUISHI, TETSURO ; SUZUKI, NOBUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-ef19ca2774729433ef1c2ac0345c7ff7ca3bde92c20ae4777dbcb40843b7ea3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Agglutination Tests</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Complement System Proteins - immunology</topic><topic>concentrated IgG</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Klebsiella pneumoniae - immunology</topic><topic>Microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRAHARA, KEIZO</creatorcontrib><creatorcontrib>KUWAE, TOYOYASU</creatorcontrib><creatorcontrib>KURATA, MUNETSUGU</creatorcontrib><creatorcontrib>MATSUISHI, TETSURO</creatorcontrib><creatorcontrib>SUZUKI, NOBUO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRAHARA, KEIZO</au><au>KUWAE, TOYOYASU</au><au>KURATA, MUNETSUGU</au><au>MATSUISHI, TETSURO</au><au>SUZUKI, NOBUO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reaction of Human Immunoglobulin G against K. pneumoniae in the Presence of Complement</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>31</volume><issue>8</issue><spage>2751</spage><epage>2755</epage><pages>2751-2755</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The bacteriolytic action of human immunoglobulin G (IgG) and its modifications (pepsin-treated and sulfonated IgG) in the presence of complement was examined with K. pneumoniae and S. aureus. Lysis of K. pneumoniae was observed when concentrated IgG was added, while that of S. arueus was not. This lytic action against K. pneumoniae was unaffected by the above modifications of IgG. 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| ispartof | Chemical and Pharmaceutical Bulletin, 1983/08/25, Vol.31(8), pp.2751-2755 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Agglutination Tests Bacteriology Biological and medical sciences Complement System Proteins - immunology concentrated IgG Fundamental and applied biological sciences. Psychology Humans Immunoglobulin G - immunology Klebsiella pneumoniae - immunology Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains |
| title | Reaction of Human Immunoglobulin G against K. pneumoniae in the Presence of Complement |
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