An OKT4+ T‐Cell Population with Suppressor Activity in Sézary Syndrome
This report describes a case of Sézary syndrome with the surface marker phenotype of a mature distinct T‐cell subset OKT3+. OKT4+. OKT8−. OKT17+. OKIal−(+). Functional studies indicated that the patient's peripheral blood cells showed a very low proliferative response to non‐specific milogens (...
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| Veröffentlicht in: | Scandinavian journal of immunology 1983-11, Vol.18 (5), p.389-398 |
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| container_title | Scandinavian journal of immunology |
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| creator | FARNARIER‐SEIDEL, C. KAPLANSKI, S. GOLSTEIN, M.‐M. JANCOVICI, E. SAYAG, J. DEPIEDS, R. |
| description | This report describes a case of Sézary syndrome with the surface marker phenotype of a mature distinct T‐cell subset OKT3+. OKT4+. OKT8−. OKT17+. OKIal−(+). Functional studies indicated that the patient's peripheral blood cells showed a very low proliferative response to non‐specific milogens (phytohaemagglutinin. concanavalin A. pokeweed mitogen) and failed to differentiate into plasma cells in a pokeweed mitogen—immunoglobulin‐synthesis‐driven system. In coculture with normal cells the leukuemic cells were able to suppress lectin‐induced T‐cell proliferation and B‐cell differentiation in a dose‐dependent manner. Suppressor function was not radiosensitive and did not require the presence of the OKT8+ subset for expression. These Sézary cells thus represent a suppressive T‐cell subset within the OKT4+ population. This subset may well correspond to the recently described OKT4+. OKT17+ normal suppressor cells. These findings would therefore illustrate a pathological and possibly clonal expansion of a normal OKT4+ suppressor T‐ceil subset. |
| doi_str_mv | 10.1111/j.1365-3083.1983.tb00870.x |
| format | Article |
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OKT4+. OKT8−. OKT17+. OKIal−(+). Functional studies indicated that the patient's peripheral blood cells showed a very low proliferative response to non‐specific milogens (phytohaemagglutinin. concanavalin A. pokeweed mitogen) and failed to differentiate into plasma cells in a pokeweed mitogen—immunoglobulin‐synthesis‐driven system. In coculture with normal cells the leukuemic cells were able to suppress lectin‐induced T‐cell proliferation and B‐cell differentiation in a dose‐dependent manner. Suppressor function was not radiosensitive and did not require the presence of the OKT8+ subset for expression. These Sézary cells thus represent a suppressive T‐cell subset within the OKT4+ population. This subset may well correspond to the recently described OKT4+. OKT17+ normal suppressor cells. These findings would therefore illustrate a pathological and possibly clonal expansion of a normal OKT4+ suppressor T‐ceil subset.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/j.1365-3083.1983.tb00870.x</identifier><identifier>PMID: 6227982</identifier><identifier>CODEN: SJIMAX</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Antibodies, Monoclonal - immunology ; Antigens, Surface - immunology ; B-Lymphocytes - cytology ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cell Differentiation ; Hematologic and hematopoietic diseases ; Humans ; Lymphocyte Activation ; Male ; Medical sciences ; Other diseases. Hematologic involvement in other diseases ; Phytohemagglutinins - pharmacology ; Pokeweed Mitogens - pharmacology ; Sezary Syndrome - immunology ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - radiation effects</subject><ispartof>Scandinavian journal of immunology, 1983-11, Vol.18 (5), p.389-398</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3989-ffa1cbe56ee4c479969d035f6ab6fa213364b8b7dfab892f8ad0c54f096c333a3</citedby><cites>FETCH-LOGICAL-c3989-ffa1cbe56ee4c479969d035f6ab6fa213364b8b7dfab892f8ad0c54f096c333a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-3083.1983.tb00870.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-3083.1983.tb00870.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9470499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6227982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FARNARIER‐SEIDEL, C.</creatorcontrib><creatorcontrib>KAPLANSKI, S.</creatorcontrib><creatorcontrib>GOLSTEIN, M.‐M.</creatorcontrib><creatorcontrib>JANCOVICI, E.</creatorcontrib><creatorcontrib>SAYAG, J.</creatorcontrib><creatorcontrib>DEPIEDS, R.</creatorcontrib><title>An OKT4+ T‐Cell Population with Suppressor Activity in Sézary Syndrome</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>This report describes a case of Sézary syndrome with the surface marker phenotype of a mature distinct T‐cell subset OKT3+. OKT4+. OKT8−. OKT17+. OKIal−(+). Functional studies indicated that the patient's peripheral blood cells showed a very low proliferative response to non‐specific milogens (phytohaemagglutinin. concanavalin A. pokeweed mitogen) and failed to differentiate into plasma cells in a pokeweed mitogen—immunoglobulin‐synthesis‐driven system. In coculture with normal cells the leukuemic cells were able to suppress lectin‐induced T‐cell proliferation and B‐cell differentiation in a dose‐dependent manner. Suppressor function was not radiosensitive and did not require the presence of the OKT8+ subset for expression. These Sézary cells thus represent a suppressive T‐cell subset within the OKT4+ population. This subset may well correspond to the recently described OKT4+. OKT17+ normal suppressor cells. These findings would therefore illustrate a pathological and possibly clonal expansion of a normal OKT4+ suppressor T‐ceil subset.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, Surface - immunology</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Pokeweed Mitogens - pharmacology</subject><subject>Sezary Syndrome - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - radiation effects</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1KAzEYhoMoWn-OIAQRNzI1mcxP4kIoxZ9qoULrOmQyCaZMZ8ZkRq0rj-A1PIc38SSmdOjeLJLF-3z5Xh4ATjDqY38u5n1MkjggiJI-Zv5qMoRoivrvW6C3ibZBDxGEAhal8R7Yd26OECZhSnbBbhKGKaNhD4wGJZw8zKJzOPv9_BqqooCPVd0WojFVCd9M8wynbV1b5Vxl4UA25tU0S2hKOP35_hB2CafLMrfVQh2CHS0Kp4669wA83VzPhnfBeHI7Gg7GgSSMskBrgWWm4kSpSEYpYwnLEYl1IrJEixATkkQZzdJci4yyUFORIxlHGrFEEkIEOQBn639rW720yjV8YZz0xUWpqtZxilKGQ4Y9eLkGpa2cs0rz2pqFr8wx4iuPfM5XsvhKFl955J1H_u6Hj7stbbZQ-Wa0E-fz0y4XTopCW1FK4zaYd44ixjx2tcbeTKGW_yjAp_cjQhn5A2h-kLs</recordid><startdate>198311</startdate><enddate>198311</enddate><creator>FARNARIER‐SEIDEL, C.</creator><creator>KAPLANSKI, S.</creator><creator>GOLSTEIN, M.‐M.</creator><creator>JANCOVICI, E.</creator><creator>SAYAG, J.</creator><creator>DEPIEDS, R.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198311</creationdate><title>An OKT4+ T‐Cell Population with Suppressor Activity in Sézary Syndrome</title><author>FARNARIER‐SEIDEL, C. ; KAPLANSKI, S. ; GOLSTEIN, M.‐M. ; JANCOVICI, E. ; SAYAG, J. ; DEPIEDS, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3989-ffa1cbe56ee4c479969d035f6ab6fa213364b8b7dfab892f8ad0c54f096c333a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, Surface - immunology</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>Pokeweed Mitogens - pharmacology</topic><topic>Sezary Syndrome - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FARNARIER‐SEIDEL, C.</creatorcontrib><creatorcontrib>KAPLANSKI, S.</creatorcontrib><creatorcontrib>GOLSTEIN, M.‐M.</creatorcontrib><creatorcontrib>JANCOVICI, E.</creatorcontrib><creatorcontrib>SAYAG, J.</creatorcontrib><creatorcontrib>DEPIEDS, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FARNARIER‐SEIDEL, C.</au><au>KAPLANSKI, S.</au><au>GOLSTEIN, M.‐M.</au><au>JANCOVICI, E.</au><au>SAYAG, J.</au><au>DEPIEDS, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An OKT4+ T‐Cell Population with Suppressor Activity in Sézary Syndrome</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>1983-11</date><risdate>1983</risdate><volume>18</volume><issue>5</issue><spage>389</spage><epage>398</epage><pages>389-398</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><coden>SJIMAX</coden><abstract>This report describes a case of Sézary syndrome with the surface marker phenotype of a mature distinct T‐cell subset OKT3+. OKT4+. OKT8−. OKT17+. OKIal−(+). Functional studies indicated that the patient's peripheral blood cells showed a very low proliferative response to non‐specific milogens (phytohaemagglutinin. concanavalin A. pokeweed mitogen) and failed to differentiate into plasma cells in a pokeweed mitogen—immunoglobulin‐synthesis‐driven system. In coculture with normal cells the leukuemic cells were able to suppress lectin‐induced T‐cell proliferation and B‐cell differentiation in a dose‐dependent manner. Suppressor function was not radiosensitive and did not require the presence of the OKT8+ subset for expression. These Sézary cells thus represent a suppressive T‐cell subset within the OKT4+ population. This subset may well correspond to the recently described OKT4+. OKT17+ normal suppressor cells. These findings would therefore illustrate a pathological and possibly clonal expansion of a normal OKT4+ suppressor T‐ceil subset.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6227982</pmid><doi>10.1111/j.1365-3083.1983.tb00870.x</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 1983-11, Vol.18 (5), p.389-398 |
| issn | 0300-9475 1365-3083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80791291 |
| source | MEDLINE; Wiley Journals |
| subjects | Adult Aged Antibodies, Monoclonal - immunology Antigens, Surface - immunology B-Lymphocytes - cytology B-Lymphocytes - immunology Biological and medical sciences Cell Differentiation Hematologic and hematopoietic diseases Humans Lymphocyte Activation Male Medical sciences Other diseases. Hematologic involvement in other diseases Phytohemagglutinins - pharmacology Pokeweed Mitogens - pharmacology Sezary Syndrome - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - radiation effects |
| title | An OKT4+ T‐Cell Population with Suppressor Activity in Sézary Syndrome |
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