Effects of a Respiratory Stimulant on Intracranial Pressure and Cerebral Blood Flow
The main cause of sudden death in patients with intracranial hypertension is respiratory failure. This study was a search for a clue to respiratory treatment which could be used at the scene of an accident. For this purpose, intravenous administration of respiratory stimulants was thought to be the...
Gespeichert in:
| Veröffentlicht in: | Neurologia medico-chirurgica 1983, Vol.23(7), pp.515-520 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 520 |
|---|---|
| container_issue | 7 |
| container_start_page | 515 |
| container_title | Neurologia medico-chirurgica |
| container_volume | 23 |
| creator | NAMBA, Hiroki AKIMOTO, Masaru YAMAURA, Akira HAGIHARA, Yashiro MAKINO, Hiroyasu SAKURAI, Koich |
| description | The main cause of sudden death in patients with intracranial hypertension is respiratory failure. This study was a search for a clue to respiratory treatment which could be used at the scene of an accident. For this purpose, intravenous administration of respiratory stimulants was thought to be the most simple measure. Doxapram hydrochloride (Doxapram) was used to stimulate respiration impaired by balloon-induced intracranial hypertension in cats. Intravenous administration of Doxapram resulted in sufficient respiratory stimulation at the dose of 1.0 mg/kg, but could not decrease PaCO2 lower than 25 torr. In 4 out of 10 cats, administration of Doxapram improved the respiratory condition and increased cerebral perfusion pressure and regional cerebral blood flow. Further investigation was required to find the best timing of Doxapram administration to maximize life preservation. |
| doi_str_mv | 10.2176/nmc.23.515 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80791267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80791267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4825-658734b31ed27426d01dcc6e1111aee67eceb312fe8466c46ce25e73592274643</originalsourceid><addsrcrecordid>eNo9UE1r3DAUFKUhXdJcei_o1EPBG31LPrZLtgkEUpL2LLTyc6tgS1vJpuTfV6430eENvBnmjQahD5RsGdXqKo5-y_hWUvkGbSgXbWMIa9-iDRGaNIYS-Q5dlhIOhDBhBDf6HJ0r2iol-QY9Xvc9-Kng1GOHH6AcQ3ZTys_4cQrjPLg44RTxbZyy89nF4Ab8PUMpcwbsYod3kOGQ6_brkFKH90P6-x6d9W4ocHnCC_Rzf_1jd9Pc3X-73X25a7wwTDZKGs3FgVPomBZMdYR23iug9TkApcFDZVkPRijlhfLAJGguW1b1SvAL9Gn1Peb0Z4Yy2TEUD0MNDWku1hDdUqZ0FX5ehT6nUjL09pjD6PKzpcQuJdpaomXc1hKr-OPJdT6M0L1KT5VVfr_ylQzeDSkOIYJ9SnOO9bfWdzRCbcfS1nBbS-dEL2BJda-DVeT0_6HdavRUJvcLXg-5PAU_wJKJtrJdcul1LAYvrP_tsoXI_wEWLJms</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80791267</pqid></control><display><type>article</type><title>Effects of a Respiratory Stimulant on Intracranial Pressure and Cerebral Blood Flow</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>NAMBA, Hiroki ; AKIMOTO, Masaru ; YAMAURA, Akira ; HAGIHARA, Yashiro ; MAKINO, Hiroyasu ; SAKURAI, Koich</creator><creatorcontrib>NAMBA, Hiroki ; AKIMOTO, Masaru ; YAMAURA, Akira ; HAGIHARA, Yashiro ; MAKINO, Hiroyasu ; SAKURAI, Koich ; Department of Neurological Surgery ; Chiba University School of Medicine ; Brain Institute</creatorcontrib><description>The main cause of sudden death in patients with intracranial hypertension is respiratory failure. This study was a search for a clue to respiratory treatment which could be used at the scene of an accident. For this purpose, intravenous administration of respiratory stimulants was thought to be the most simple measure. Doxapram hydrochloride (Doxapram) was used to stimulate respiration impaired by balloon-induced intracranial hypertension in cats. Intravenous administration of Doxapram resulted in sufficient respiratory stimulation at the dose of 1.0 mg/kg, but could not decrease PaCO2 lower than 25 torr. In 4 out of 10 cats, administration of Doxapram improved the respiratory condition and increased cerebral perfusion pressure and regional cerebral blood flow. Further investigation was required to find the best timing of Doxapram administration to maximize life preservation.</description><identifier>ISSN: 0470-8105</identifier><identifier>EISSN: 1349-8029</identifier><identifier>DOI: 10.2176/nmc.23.515</identifier><identifier>PMID: 6196653</identifier><language>eng</language><publisher>Japan: The Japan Neurosurgical Society</publisher><subject>Animals ; Cats ; cerebral blood flow ; Cerebrovascular Circulation ; Doxapram ; Doxapram - therapeutic use ; Female ; Intracranial Pressure ; Male ; Pseudotumor Cerebri - complications ; Respiratory Insufficiency - drug therapy ; respiratory stimulant</subject><ispartof>Neurologia medico-chirurgica, 1983, Vol.23(7), pp.515-520</ispartof><rights>The Japan Neurosurgical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6196653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAMBA, Hiroki</creatorcontrib><creatorcontrib>AKIMOTO, Masaru</creatorcontrib><creatorcontrib>YAMAURA, Akira</creatorcontrib><creatorcontrib>HAGIHARA, Yashiro</creatorcontrib><creatorcontrib>MAKINO, Hiroyasu</creatorcontrib><creatorcontrib>SAKURAI, Koich</creatorcontrib><creatorcontrib>Department of Neurological Surgery</creatorcontrib><creatorcontrib>Chiba University School of Medicine</creatorcontrib><creatorcontrib>Brain Institute</creatorcontrib><title>Effects of a Respiratory Stimulant on Intracranial Pressure and Cerebral Blood Flow</title><title>Neurologia medico-chirurgica</title><addtitle>Neurol. Med. Chir.(Tokyo)</addtitle><description>The main cause of sudden death in patients with intracranial hypertension is respiratory failure. This study was a search for a clue to respiratory treatment which could be used at the scene of an accident. For this purpose, intravenous administration of respiratory stimulants was thought to be the most simple measure. Doxapram hydrochloride (Doxapram) was used to stimulate respiration impaired by balloon-induced intracranial hypertension in cats. Intravenous administration of Doxapram resulted in sufficient respiratory stimulation at the dose of 1.0 mg/kg, but could not decrease PaCO2 lower than 25 torr. In 4 out of 10 cats, administration of Doxapram improved the respiratory condition and increased cerebral perfusion pressure and regional cerebral blood flow. Further investigation was required to find the best timing of Doxapram administration to maximize life preservation.</description><subject>Animals</subject><subject>Cats</subject><subject>cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Doxapram</subject><subject>Doxapram - therapeutic use</subject><subject>Female</subject><subject>Intracranial Pressure</subject><subject>Male</subject><subject>Pseudotumor Cerebri - complications</subject><subject>Respiratory Insufficiency - drug therapy</subject><subject>respiratory stimulant</subject><issn>0470-8105</issn><issn>1349-8029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1r3DAUFKUhXdJcei_o1EPBG31LPrZLtgkEUpL2LLTyc6tgS1vJpuTfV6430eENvBnmjQahD5RsGdXqKo5-y_hWUvkGbSgXbWMIa9-iDRGaNIYS-Q5dlhIOhDBhBDf6HJ0r2iol-QY9Xvc9-Kng1GOHH6AcQ3ZTys_4cQrjPLg44RTxbZyy89nF4Ab8PUMpcwbsYod3kOGQ6_brkFKH90P6-x6d9W4ocHnCC_Rzf_1jd9Pc3X-73X25a7wwTDZKGs3FgVPomBZMdYR23iug9TkApcFDZVkPRijlhfLAJGguW1b1SvAL9Gn1Peb0Z4Yy2TEUD0MNDWku1hDdUqZ0FX5ehT6nUjL09pjD6PKzpcQuJdpaomXc1hKr-OPJdT6M0L1KT5VVfr_ylQzeDSkOIYJ9SnOO9bfWdzRCbcfS1nBbS-dEL2BJda-DVeT0_6HdavRUJvcLXg-5PAU_wJKJtrJdcul1LAYvrP_tsoXI_wEWLJms</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>NAMBA, Hiroki</creator><creator>AKIMOTO, Masaru</creator><creator>YAMAURA, Akira</creator><creator>HAGIHARA, Yashiro</creator><creator>MAKINO, Hiroyasu</creator><creator>SAKURAI, Koich</creator><general>The Japan Neurosurgical Society</general><general>THE JAPAN NEUROSURGICAL SOCIETY</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Effects of a Respiratory Stimulant on Intracranial Pressure and Cerebral Blood Flow</title><author>NAMBA, Hiroki ; AKIMOTO, Masaru ; YAMAURA, Akira ; HAGIHARA, Yashiro ; MAKINO, Hiroyasu ; SAKURAI, Koich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4825-658734b31ed27426d01dcc6e1111aee67eceb312fe8466c46ce25e73592274643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Cats</topic><topic>cerebral blood flow</topic><topic>Cerebrovascular Circulation</topic><topic>Doxapram</topic><topic>Doxapram - therapeutic use</topic><topic>Female</topic><topic>Intracranial Pressure</topic><topic>Male</topic><topic>Pseudotumor Cerebri - complications</topic><topic>Respiratory Insufficiency - drug therapy</topic><topic>respiratory stimulant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAMBA, Hiroki</creatorcontrib><creatorcontrib>AKIMOTO, Masaru</creatorcontrib><creatorcontrib>YAMAURA, Akira</creatorcontrib><creatorcontrib>HAGIHARA, Yashiro</creatorcontrib><creatorcontrib>MAKINO, Hiroyasu</creatorcontrib><creatorcontrib>SAKURAI, Koich</creatorcontrib><creatorcontrib>Department of Neurological Surgery</creatorcontrib><creatorcontrib>Chiba University School of Medicine</creatorcontrib><creatorcontrib>Brain Institute</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurologia medico-chirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAMBA, Hiroki</au><au>AKIMOTO, Masaru</au><au>YAMAURA, Akira</au><au>HAGIHARA, Yashiro</au><au>MAKINO, Hiroyasu</au><au>SAKURAI, Koich</au><aucorp>Department of Neurological Surgery</aucorp><aucorp>Chiba University School of Medicine</aucorp><aucorp>Brain Institute</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Respiratory Stimulant on Intracranial Pressure and Cerebral Blood Flow</atitle><jtitle>Neurologia medico-chirurgica</jtitle><addtitle>Neurol. Med. Chir.(Tokyo)</addtitle><date>1983</date><risdate>1983</risdate><volume>23</volume><issue>7</issue><spage>515</spage><epage>520</epage><pages>515-520</pages><issn>0470-8105</issn><eissn>1349-8029</eissn><abstract>The main cause of sudden death in patients with intracranial hypertension is respiratory failure. This study was a search for a clue to respiratory treatment which could be used at the scene of an accident. For this purpose, intravenous administration of respiratory stimulants was thought to be the most simple measure. Doxapram hydrochloride (Doxapram) was used to stimulate respiration impaired by balloon-induced intracranial hypertension in cats. Intravenous administration of Doxapram resulted in sufficient respiratory stimulation at the dose of 1.0 mg/kg, but could not decrease PaCO2 lower than 25 torr. In 4 out of 10 cats, administration of Doxapram improved the respiratory condition and increased cerebral perfusion pressure and regional cerebral blood flow. Further investigation was required to find the best timing of Doxapram administration to maximize life preservation.</abstract><cop>Japan</cop><pub>The Japan Neurosurgical Society</pub><pmid>6196653</pmid><doi>10.2176/nmc.23.515</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0470-8105 |
| ispartof | Neurologia medico-chirurgica, 1983, Vol.23(7), pp.515-520 |
| issn | 0470-8105 1349-8029 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80791267 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Cats cerebral blood flow Cerebrovascular Circulation Doxapram Doxapram - therapeutic use Female Intracranial Pressure Male Pseudotumor Cerebri - complications Respiratory Insufficiency - drug therapy respiratory stimulant |
| title | Effects of a Respiratory Stimulant on Intracranial Pressure and Cerebral Blood Flow |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T10%3A38%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%20Respiratory%20Stimulant%20on%20Intracranial%20Pressure%20and%20Cerebral%20Blood%20Flow&rft.jtitle=Neurologia%20medico-chirurgica&rft.au=NAMBA,%20Hiroki&rft.aucorp=Department%20of%20Neurological%20Surgery&rft.date=1983&rft.volume=23&rft.issue=7&rft.spage=515&rft.epage=520&rft.pages=515-520&rft.issn=0470-8105&rft.eissn=1349-8029&rft_id=info:doi/10.2176/nmc.23.515&rft_dat=%3Cproquest_cross%3E80791267%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80791267&rft_id=info:pmid/6196653&rfr_iscdi=true |