Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop
Mitochondrial DNA (mtDNA) is unusual in its rapid rate of evolution 1 and high level of intraspecies sequence variation 2 . The latter is thought to be related to the strict maternal inheritance of mtDNA, which effectively isolates within a species mitochondrial gene pools that accumulate mutations...
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Veröffentlicht in: | Nature (London) 1983-11, Vol.306 (5941), p.400-402 |
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creator | Olivo, Paul D. Van de Walle, Michael J. Laipis, Philip J. Hauswirth, William W. |
description | Mitochondrial DNA (mtDNA) is unusual in its rapid rate of evolution
1
and high level of intraspecies sequence variation
2
. The latter is thought to be related to the strict maternal inheritance of mtDNA, which effectively isolates within a species mitochondrial gene pools that accumulate mutations and vary independently
3
A fundamental and as yet unexplained aspect of this process is how, in the face of somatic and germ-line mtDNA ploidy of 10
3
to 10
5
(refs 4, 5), individual variant mtDNA molecules resulting from mutational events can come to dominate the large intracellular mtDNA population so rapidly. To help answer this question, we have determined here the nucleotide sequence of all or part of the D-loop region in 14 maternally related Holstein cows. Fourdifferent D-loop sequences can be distinguished in the mtDNA of these animals. One explanation is that multiple mitochondrial genotypes existed in the maternal germ tine and that expansion or segregation of one of these genotypes during oogenesis or early development led to the rapid genotypic shifts observed. |
doi_str_mv | 10.1038/306400a0 |
format | Article |
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1
and high level of intraspecies sequence variation
2
. The latter is thought to be related to the strict maternal inheritance of mtDNA, which effectively isolates within a species mitochondrial gene pools that accumulate mutations and vary independently
3
A fundamental and as yet unexplained aspect of this process is how, in the face of somatic and germ-line mtDNA ploidy of 10
3
to 10
5
(refs 4, 5), individual variant mtDNA molecules resulting from mutational events can come to dominate the large intracellular mtDNA population so rapidly. To help answer this question, we have determined here the nucleotide sequence of all or part of the D-loop region in 14 maternally related Holstein cows. Fourdifferent D-loop sequences can be distinguished in the mtDNA of these animals. One explanation is that multiple mitochondrial genotypes existed in the maternal germ tine and that expansion or segregation of one of these genotypes during oogenesis or early development led to the rapid genotypic shifts observed.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/306400a0</identifier><identifier>PMID: 6646218</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Base Sequence ; Biological Evolution ; Cattle ; DNA, Mitochondrial - genetics ; Genetic Variation ; Humanities and Social Sciences ; letter ; multidisciplinary ; Pedigree ; RNA, Transfer - genetics ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1983-11, Vol.306 (5941), p.400-402</ispartof><rights>Springer Nature Limited 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/306400a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/306400a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6646218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olivo, Paul D.</creatorcontrib><creatorcontrib>Van de Walle, Michael J.</creatorcontrib><creatorcontrib>Laipis, Philip J.</creatorcontrib><creatorcontrib>Hauswirth, William W.</creatorcontrib><title>Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Mitochondrial DNA (mtDNA) is unusual in its rapid rate of evolution
1
and high level of intraspecies sequence variation
2
. The latter is thought to be related to the strict maternal inheritance of mtDNA, which effectively isolates within a species mitochondrial gene pools that accumulate mutations and vary independently
3
A fundamental and as yet unexplained aspect of this process is how, in the face of somatic and germ-line mtDNA ploidy of 10
3
to 10
5
(refs 4, 5), individual variant mtDNA molecules resulting from mutational events can come to dominate the large intracellular mtDNA population so rapidly. To help answer this question, we have determined here the nucleotide sequence of all or part of the D-loop region in 14 maternally related Holstein cows. Fourdifferent D-loop sequences can be distinguished in the mtDNA of these animals. One explanation is that multiple mitochondrial genotypes existed in the maternal germ tine and that expansion or segregation of one of these genotypes during oogenesis or early development led to the rapid genotypic shifts observed.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological Evolution</subject><subject>Cattle</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Genetic Variation</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Pedigree</subject><subject>RNA, Transfer - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9Lw0AQxRdRaq2CX0DYk-AhOrub7G6PpfUflHrRq0uSnbRbkmzMJoV-e1Naz55mht9j4L1HyC2DRwZCPwmQMUAKZ2TMYiWjWGp1TsYAXEeghbwkVyFsASBhKh6RkZSx5EyPyfeqz0v0nbNIA_70WOdIcTech6XwLW3Txlm6xtp3-8blNGxc0QXqatptkGZ-52qklet8vvG1bV1a0sVqRhdR6X1zTS6KtAx4c5oT8vXy_Dl_i5Yfr-_z2TJqOIguyqRVPMszlUimrRJYSJ1AIlVhIVUiEcxyNk215Kg5DDTRcWw1SswQVIFiQu6Pf5vWDyZCZyoXcizLtEbfB6NBaS01-1fIhEpgqvggvDsJ-6xCa5rWVWm7N6fkBv5w5GEg9Rpbs_V9Ww8mDQNzKMX8lSJ-AYCte9A</recordid><startdate>19831124</startdate><enddate>19831124</enddate><creator>Olivo, Paul D.</creator><creator>Van de Walle, Michael J.</creator><creator>Laipis, Philip J.</creator><creator>Hauswirth, William W.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19831124</creationdate><title>Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop</title><author>Olivo, Paul D. ; Van de Walle, Michael J. ; Laipis, Philip J. ; Hauswirth, William W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p203t-b6d72bcb75618d73ef6850567fd0a73531d219a862e820ef65844d8e6ebe07fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological Evolution</topic><topic>Cattle</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Genetic Variation</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Pedigree</topic><topic>RNA, Transfer - genetics</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olivo, Paul D.</creatorcontrib><creatorcontrib>Van de Walle, Michael J.</creatorcontrib><creatorcontrib>Laipis, Philip J.</creatorcontrib><creatorcontrib>Hauswirth, William W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olivo, Paul D.</au><au>Van de Walle, Michael J.</au><au>Laipis, Philip J.</au><au>Hauswirth, William W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1983-11-24</date><risdate>1983</risdate><volume>306</volume><issue>5941</issue><spage>400</spage><epage>402</epage><pages>400-402</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Mitochondrial DNA (mtDNA) is unusual in its rapid rate of evolution
1
and high level of intraspecies sequence variation
2
. The latter is thought to be related to the strict maternal inheritance of mtDNA, which effectively isolates within a species mitochondrial gene pools that accumulate mutations and vary independently
3
A fundamental and as yet unexplained aspect of this process is how, in the face of somatic and germ-line mtDNA ploidy of 10
3
to 10
5
(refs 4, 5), individual variant mtDNA molecules resulting from mutational events can come to dominate the large intracellular mtDNA population so rapidly. To help answer this question, we have determined here the nucleotide sequence of all or part of the D-loop region in 14 maternally related Holstein cows. Fourdifferent D-loop sequences can be distinguished in the mtDNA of these animals. One explanation is that multiple mitochondrial genotypes existed in the maternal germ tine and that expansion or segregation of one of these genotypes during oogenesis or early development led to the rapid genotypic shifts observed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6646218</pmid><doi>10.1038/306400a0</doi><tpages>3</tpages></addata></record> |
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source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
subjects | Animals Base Sequence Biological Evolution Cattle DNA, Mitochondrial - genetics Genetic Variation Humanities and Social Sciences letter multidisciplinary Pedigree RNA, Transfer - genetics Science Science (multidisciplinary) |
title | Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop |
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