A comparison of the effects of vitamin B12 and aspirin in three experimental pain models in rats and mice
The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activ...
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| Veröffentlicht in: | Psychopharmacologia 1983, Vol.81 (3), p.228-231 |
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| container_end_page | 231 |
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| container_title | Psychopharmacologia |
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| creator | ESCHALIER, A AUMAÎTRE, O DECAMPS, A DORDAIN, G |
| description | The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the three tests at any of the doses used, whether the drug was administered as a single injection or as a series of daily injections lasting 7 days. These results run counter to those of clinical trials in man, though close scrutiny of the experimental procedures used in these trials often reveals a lack of rigor which casts doubts on their validity. This consideration, together with the negative findings reported here, suggests that the clinical use of vitamin B12 as an analgesic may be inappropriate. |
| doi_str_mv | 10.1007/BF00427267 |
| format | Article |
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Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the three tests at any of the doses used, whether the drug was administered as a single injection or as a series of daily injections lasting 7 days. These results run counter to those of clinical trials in man, though close scrutiny of the experimental procedures used in these trials often reveals a lack of rigor which casts doubts on their validity. This consideration, together with the negative findings reported here, suggests that the clinical use of vitamin B12 as an analgesic may be inappropriate.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/BF00427267</identifier><identifier>PMID: 6417710</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Analgesics ; Animals ; Aspirin - pharmacology ; Benzoquinones ; Biological and medical sciences ; Electroshock ; Female ; Male ; Medical sciences ; Mice ; Neuropharmacology ; Pain - drug therapy ; Pharmacology. 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Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the three tests at any of the doses used, whether the drug was administered as a single injection or as a series of daily injections lasting 7 days. These results run counter to those of clinical trials in man, though close scrutiny of the experimental procedures used in these trials often reveals a lack of rigor which casts doubts on their validity. This consideration, together with the negative findings reported here, suggests that the clinical use of vitamin B12 as an analgesic may be inappropriate.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Aspirin - pharmacology</subject><subject>Benzoquinones</subject><subject>Biological and medical sciences</subject><subject>Electroshock</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Pain - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinones - antagonists & inhibitors</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reaction Time - drug effects</subject><subject>Vitamin B 12 - pharmacology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5iAchOvuRbHJsi1Wh4EXPYbOZpSv5cjcV_fduaKjDwDAzz7wwLyHXFB4ogHxcbQAEkyyVJ2ROBWcxA8lOyRyA85jTJDsnF95_QgiRiRmZpYJKSWFO7DLSXdMrZ33XRp2Jhh1GaAzqwY_ttx1UY9toRVmk2ipSvrcu9CGHncPA_vTobIPtoOqoV2HedBXWfiScCiLjVWM1XpIzo2qPV1NdkI_N0_v6Jd6-Pb-ul9tYM5YOsaBlJjmigfGHBGWWmTIvdYU61yWkUGIGwJJSq6qSvEoVA6FzmpoUkPKEL8jdQbd33dce_VA01musa9Vit_dFBkEySUbw_gBq13nv0BR9eES534JCMfpa_Psa4JtJdV82WB3Ryciwv532ymtVG6dabf0Ry5NEUCr5Hxu0fpA</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>ESCHALIER, A</creator><creator>AUMAÎTRE, O</creator><creator>DECAMPS, A</creator><creator>DORDAIN, G</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>A comparison of the effects of vitamin B12 and aspirin in three experimental pain models in rats and mice</title><author>ESCHALIER, A ; AUMAÎTRE, O ; DECAMPS, A ; DORDAIN, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-41b873eef020725e788fb9bcdec9cb060be80025bcadd73d6a204c916f60e1353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Aspirin - pharmacology</topic><topic>Benzoquinones</topic><topic>Biological and medical sciences</topic><topic>Electroshock</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neuropharmacology</topic><topic>Pain - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinones - antagonists & inhibitors</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reaction Time - drug effects</topic><topic>Vitamin B 12 - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ESCHALIER, A</creatorcontrib><creatorcontrib>AUMAÎTRE, O</creatorcontrib><creatorcontrib>DECAMPS, A</creatorcontrib><creatorcontrib>DORDAIN, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ESCHALIER, A</au><au>AUMAÎTRE, O</au><au>DECAMPS, A</au><au>DORDAIN, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the effects of vitamin B12 and aspirin in three experimental pain models in rats and mice</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1983</date><risdate>1983</risdate><volume>81</volume><issue>3</issue><spage>228</spage><epage>231</epage><pages>228-231</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the three tests at any of the doses used, whether the drug was administered as a single injection or as a series of daily injections lasting 7 days. These results run counter to those of clinical trials in man, though close scrutiny of the experimental procedures used in these trials often reveals a lack of rigor which casts doubts on their validity. This consideration, together with the negative findings reported here, suggests that the clinical use of vitamin B12 as an analgesic may be inappropriate.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6417710</pmid><doi>10.1007/BF00427267</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacologia, 1983, Vol.81 (3), p.228-231 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Analgesics Animals Aspirin - pharmacology Benzoquinones Biological and medical sciences Electroshock Female Male Medical sciences Mice Neuropharmacology Pain - drug therapy Pharmacology. Drug treatments Quinones - antagonists & inhibitors Rats Rats, Inbred Strains Reaction Time - drug effects Vitamin B 12 - pharmacology |
| title | A comparison of the effects of vitamin B12 and aspirin in three experimental pain models in rats and mice |
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