Detection of micrometastases in patients with primary breast cancer
An immunocytochemical method was used to screen smears obtained at primary surgery from multiple bone-marrow sites in 110 patients with breast cancer; at this time other techniques did not reveal metastases. Tumour cells were detected in the bone-marrow of 31 (28%) patients. The number of cells dete...
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| Veröffentlicht in: | The Lancet (British edition) 1983-12, Vol.2 (8362), p.1271-1274 |
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| container_end_page | 1274 |
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| container_issue | 8362 |
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| container_title | The Lancet (British edition) |
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| creator | REDDING, W. H MONAGHAN, P NEVILLE, A. M IMRIE, S. F ORMEROD, M. G GAZET, J.-C COOMBES, R. C CLINK, H. M DEARNALEY, D. P SLOANE, J. P POWLES, T. J |
| description | An immunocytochemical method was used to screen smears obtained at primary surgery from multiple bone-marrow sites in 110 patients with breast cancer; at this time other techniques did not reveal metastases. Tumour cells were detected in the bone-marrow of 31 (28%) patients. The number of cells detected ranged from 1 to greater than 500; none was detected in conventionally stained smears. Patients in whom conventional criteria indicated a very poor prognosis seemed more likely to have such micrometastases. A further follow-up period is required to determine whether patients with micrometastases relapse earlier than those in whom no tumour cells are demonstrable. |
| format | Article |
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H ; MONAGHAN, P ; NEVILLE, A. M ; IMRIE, S. F ; ORMEROD, M. G ; GAZET, J.-C ; COOMBES, R. C ; CLINK, H. M ; DEARNALEY, D. P ; SLOANE, J. P ; POWLES, T. J</creator><creatorcontrib>REDDING, W. H ; MONAGHAN, P ; NEVILLE, A. M ; IMRIE, S. F ; ORMEROD, M. G ; GAZET, J.-C ; COOMBES, R. C ; CLINK, H. M ; DEARNALEY, D. P ; SLOANE, J. P ; POWLES, T. J</creatorcontrib><description>An immunocytochemical method was used to screen smears obtained at primary surgery from multiple bone-marrow sites in 110 patients with breast cancer; at this time other techniques did not reveal metastases. Tumour cells were detected in the bone-marrow of 31 (28%) patients. The number of cells detected ranged from 1 to greater than 500; none was detected in conventionally stained smears. Patients in whom conventional criteria indicated a very poor prognosis seemed more likely to have such micrometastases. A further follow-up period is required to determine whether patients with micrometastases relapse earlier than those in whom no tumour cells are demonstrable.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>PMID: 6139619</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Lancet</publisher><subject>Adult ; Aged ; Antigens, Neoplasm - analysis ; Antigens, Surface - analysis ; Biological and medical sciences ; Bone Marrow - immunology ; Bone Marrow - pathology ; Bone Neoplasms - diagnosis ; Bone Neoplasms - secondary ; Breast Neoplasms - immunology ; Breast Neoplasms - pathology ; Epithelium - immunology ; Female ; Gynecology. Andrology. 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Patients in whom conventional criteria indicated a very poor prognosis seemed more likely to have such micrometastases. A further follow-up period is required to determine whether patients with micrometastases relapse earlier than those in whom no tumour cells are demonstrable.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Antigens, Surface - analysis</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - pathology</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Bone Neoplasms - secondary</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - pathology</subject><subject>Epithelium - immunology</subject><subject>Female</subject><subject>Gynecology. Andrology. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of micrometastases in patients with primary breast cancer</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1983-12-03</date><risdate>1983</risdate><volume>2</volume><issue>8362</issue><spage>1271</spage><epage>1274</epage><pages>1271-1274</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>An immunocytochemical method was used to screen smears obtained at primary surgery from multiple bone-marrow sites in 110 patients with breast cancer; at this time other techniques did not reveal metastases. Tumour cells were detected in the bone-marrow of 31 (28%) patients. The number of cells detected ranged from 1 to greater than 500; none was detected in conventionally stained smears. Patients in whom conventional criteria indicated a very poor prognosis seemed more likely to have such micrometastases. A further follow-up period is required to determine whether patients with micrometastases relapse earlier than those in whom no tumour cells are demonstrable.</abstract><cop>London</cop><pub>Lancet</pub><pmid>6139619</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1983-12, Vol.2 (8362), p.1271-1274 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Antigens, Neoplasm - analysis Antigens, Surface - analysis Biological and medical sciences Bone Marrow - immunology Bone Marrow - pathology Bone Neoplasms - diagnosis Bone Neoplasms - secondary Breast Neoplasms - immunology Breast Neoplasms - pathology Epithelium - immunology Female Gynecology. Andrology. Obstetrics Humans Immunoenzyme Techniques Mammary gland diseases Medical sciences Middle Aged Tumors |
| title | Detection of micrometastases in patients with primary breast cancer |
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