Survival of dog kidneys subjected to high pressures: Necrosis of kidneys after freezing

Dog kidneys were perfused to ensure cooling and then subjected to high pressures before being reimplanted into the autologous donor and tested by an immediate contralateral nephrectomy. Such kidneys exposed to pressures as high as 15,000 psi for 5 min regained excellent function quickly and maintain...

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Veröffentlicht in:	Cryobiology 1970-09, Vol.7 (2), p.122-128
Hauptverfasser:	Karow, Armand M., Liu, W.P., Humphries, Arthur L.
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Sprache:	eng
Schlagworte:	Animals Cryoprotective Agents
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container_end_page	128
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container_title	Cryobiology
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creator	Karow, Armand M. Liu, W.P. Humphries, Arthur L.
description	Dog kidneys were perfused to ensure cooling and then subjected to high pressures before being reimplanted into the autologous donor and tested by an immediate contralateral nephrectomy. Such kidneys exposed to pressures as high as 15,000 psi for 5 min regained excellent function quickly and maintained the life of the dog. Lower pressures were tolerated for longer periods of time. All kidneys that were frozen became necrotic after reimplantation. Thus we were unable to demonstrate that high pressures, to facilitate rapid, uniform thawing, were of any value.
doi_str_mv	10.1016/0011-2240(70)90007-6
format	Article
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Such kidneys exposed to pressures as high as 15,000 psi for 5 min regained excellent function quickly and maintained the life of the dog. Lower pressures were tolerated for longer periods of time. All kidneys that were frozen became necrotic after reimplantation. 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source	MEDLINE; Elsevier ScienceDirect Journals
subjects	Animals Cryoprotective Agents
title	Survival of dog kidneys subjected to high pressures: Necrosis of kidneys after freezing
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