Serum copper and ceruloplasmin levels in rheumatoid arthritis and degenerative joint disease and their pharmacological implications
Serum copper concentration and ceruloplasmin activity were measured in patients with clinically established rheumatoid arthritis (R.A.) during the active phase, in patients with degenerative joint disease (D.J.D.) and in normal subjects. Copper and ceruloplasmin serum levels are significantly increa...
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| Veröffentlicht in: | Pharmacological research communications 1983-10, Vol.15 (9), p.859-867 |
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| container_issue | 9 |
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| container_title | Pharmacological research communications |
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| creator | Conforti, A. Franco, L. Menegale, G. Milanino, R. Piemonte, G. Velo, G.P. |
| description | Serum copper concentration and ceruloplasmin activity were measured in patients with clinically established rheumatoid arthritis (R.A.) during the active phase, in patients with degenerative joint disease (D.J.D.) and in normal subjects.
Copper and ceruloplasmin serum levels are significantly increased (P < 0.01) in the arthritic group, but not in the degenerative joint disease group. Copper and ceruloplasmin levels are high significantly correlated in all the groups.
This parallel enhancement of serum copper and ceruloplasmin in R.A. is commented in view of a possible protective role of endogenous copper and/or ceruloplasmin in inflammation. |
| doi_str_mv | 10.1016/S0031-6989(83)80093-9 |
| format | Article |
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Copper and ceruloplasmin serum levels are significantly increased (P < 0.01) in the arthritic group, but not in the degenerative joint disease group. Copper and ceruloplasmin levels are high significantly correlated in all the groups.
This parallel enhancement of serum copper and ceruloplasmin in R.A. is commented in view of a possible protective role of endogenous copper and/or ceruloplasmin in inflammation.</description><identifier>ISSN: 0031-6989</identifier><identifier>EISSN: 1879-2936</identifier><identifier>DOI: 10.1016/S0031-6989(83)80093-9</identifier><identifier>PMID: 6647528</identifier><language>eng</language><publisher>Orlando, FL: Elsevier B.V</publisher><subject>Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - drug therapy ; Biological and medical sciences ; Ceruloplasmin - metabolism ; Copper - blood ; Diseases of the osteoarticular system ; Female ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Osteoarthritis - blood ; Osteoarthritis - drug therapy</subject><ispartof>Pharmacological research communications, 1983-10, Vol.15 (9), p.859-867</ispartof><rights>1983 The Italian Pharmacological Society</rights><rights>1984 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-ad80d66015daf6c444de5b45793ca8005472826548ffb66243a83c56a98fa6ba3</citedby><cites>FETCH-LOGICAL-c389t-ad80d66015daf6c444de5b45793ca8005472826548ffb66243a83c56a98fa6ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9501161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6647528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conforti, A.</creatorcontrib><creatorcontrib>Franco, L.</creatorcontrib><creatorcontrib>Menegale, G.</creatorcontrib><creatorcontrib>Milanino, R.</creatorcontrib><creatorcontrib>Piemonte, G.</creatorcontrib><creatorcontrib>Velo, G.P.</creatorcontrib><title>Serum copper and ceruloplasmin levels in rheumatoid arthritis and degenerative joint disease and their pharmacological implications</title><title>Pharmacological research communications</title><addtitle>Pharmacol Res Commun</addtitle><description>Serum copper concentration and ceruloplasmin activity were measured in patients with clinically established rheumatoid arthritis (R.A.) during the active phase, in patients with degenerative joint disease (D.J.D.) and in normal subjects.
Copper and ceruloplasmin serum levels are significantly increased (P < 0.01) in the arthritic group, but not in the degenerative joint disease group. Copper and ceruloplasmin levels are high significantly correlated in all the groups.
This parallel enhancement of serum copper and ceruloplasmin in R.A. is commented in view of a possible protective role of endogenous copper and/or ceruloplasmin in inflammation.</description><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Ceruloplasmin - metabolism</subject><subject>Copper - blood</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Osteoarthritis - blood</subject><subject>Osteoarthritis - drug therapy</subject><issn>0031-6989</issn><issn>1879-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2PFCEQhonRrOPqT9iEgzF6aIWmm4aTMRu_kk08rJ5JDVTvsKGbFuhJPPvHZT4yV08UvE8V8BByw9l7zrj8cM-Y4I3USr9V4p1iTItGPyEbrgbdtFrIp2RzQZ6TFzk_1m0rObsiV1J2Q9-qDfl7j2mdqI3LgonC7KitByEuAfLkZxpwjyHTWqUdrhOU6B2FVHbJF5-PDQ4fcMYExe-RPkY_F-p8Rsh4jMsOfaLLDtIENob44C0E6qcl1KL4OOeX5NkIIeOr83pNfn35_PP2W3P34-v32093jRVKlwacYk5KxnsHo7Rd1znst10_aGGh_r_vhla1su_UOG6lbDsBStheglYjyC2Ia_LmNHdJ8feKuZjJZ4shwIxxzUaxQTGpdQX7E2hTzDnhaJbkJ0h_DGfmIN8c5ZuDWaOEOco3h76b8wXrdkJ36Trbrvnrcw65ShgTzNbnC6Z7xrnkFft4wqp53HtMJluPs0XnE9piXPT_ecg_7NGj9g</recordid><startdate>198310</startdate><enddate>198310</enddate><creator>Conforti, A.</creator><creator>Franco, L.</creator><creator>Menegale, G.</creator><creator>Milanino, R.</creator><creator>Piemonte, G.</creator><creator>Velo, G.P.</creator><general>Elsevier B.V</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198310</creationdate><title>Serum copper and ceruloplasmin levels in rheumatoid arthritis and degenerative joint disease and their pharmacological implications</title><author>Conforti, A. ; Franco, L. ; Menegale, G. ; Milanino, R. ; Piemonte, G. ; Velo, G.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ad80d66015daf6c444de5b45793ca8005472826548ffb66243a83c56a98fa6ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Ceruloplasmin - metabolism</topic><topic>Copper - blood</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Osteoarthritis - blood</topic><topic>Osteoarthritis - drug therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Conforti, A.</creatorcontrib><creatorcontrib>Franco, L.</creatorcontrib><creatorcontrib>Menegale, G.</creatorcontrib><creatorcontrib>Milanino, R.</creatorcontrib><creatorcontrib>Piemonte, G.</creatorcontrib><creatorcontrib>Velo, G.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conforti, A.</au><au>Franco, L.</au><au>Menegale, G.</au><au>Milanino, R.</au><au>Piemonte, G.</au><au>Velo, G.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum copper and ceruloplasmin levels in rheumatoid arthritis and degenerative joint disease and their pharmacological implications</atitle><jtitle>Pharmacological research communications</jtitle><addtitle>Pharmacol Res Commun</addtitle><date>1983-10</date><risdate>1983</risdate><volume>15</volume><issue>9</issue><spage>859</spage><epage>867</epage><pages>859-867</pages><issn>0031-6989</issn><eissn>1879-2936</eissn><abstract>Serum copper concentration and ceruloplasmin activity were measured in patients with clinically established rheumatoid arthritis (R.A.) during the active phase, in patients with degenerative joint disease (D.J.D.) and in normal subjects.
Copper and ceruloplasmin serum levels are significantly increased (P < 0.01) in the arthritic group, but not in the degenerative joint disease group. Copper and ceruloplasmin levels are high significantly correlated in all the groups.
This parallel enhancement of serum copper and ceruloplasmin in R.A. is commented in view of a possible protective role of endogenous copper and/or ceruloplasmin in inflammation.</abstract><cop>Orlando, FL</cop><cop>London</cop><pub>Elsevier B.V</pub><pmid>6647528</pmid><doi>10.1016/S0031-6989(83)80093-9</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pharmacological research communications, 1983-10, Vol.15 (9), p.859-867 |
| issn | 0031-6989 1879-2936 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Biological and medical sciences Ceruloplasmin - metabolism Copper - blood Diseases of the osteoarticular system Female Humans Inflammatory joint diseases Male Medical sciences Osteoarthritis - blood Osteoarthritis - drug therapy |
| title | Serum copper and ceruloplasmin levels in rheumatoid arthritis and degenerative joint disease and their pharmacological implications |
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