Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites
In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of hista...
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| Veröffentlicht in: | The New England journal of medicine 1983-12, Vol.309 (26), p.1603-1605 |
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| container_end_page | 1605 |
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| container_issue | 26 |
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| container_title | The New England journal of medicine |
| container_volume | 309 |
| creator | KEYZER, J. J DE MONCHY, J. G. R VAN DOORMAAL, J. J VAN VOORST VADER, P. C |
| description | In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself. |
| doi_str_mv | 10.1056/NEJM198312293092603 |
| format | Article |
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J ; DE MONCHY, J. G. R ; VAN DOORMAAL, J. J ; VAN VOORST VADER, P. C</creator><creatorcontrib>KEYZER, J. J ; DE MONCHY, J. G. R ; VAN DOORMAAL, J. J ; VAN VOORST VADER, P. C</creatorcontrib><description>In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198312293092603</identifier><identifier>PMID: 6646186</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Female ; Hematologic and hematopoietic diseases ; Histamine - urine ; Humans ; Imidazoles - urine ; Male ; Medical sciences ; Methylhistamines - urine ; Middle Aged ; Other diseases. 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In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histamine - urine</subject><subject>Humans</subject><subject>Imidazoles - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylhistamines - urine</subject><subject>Middle Aged</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Urticaria Pigmentosa - diagnosis</subject><subject>Urticaria Pigmentosa - urine</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFKxDAQhoMo67r6BCL0IN6qSSZNk6PIqiurgui5JM3UjTTt2rTCvr1Vi3MZhu9j-GcIOWX0ktFMXj0tHx6ZVsA410A1lxT2yJxlAKkQVO6TOaVcpSLXcEiOYvygYzGhZ2QmpZBMyTl5WYVt136hS5w3700bfUzaKgkm9m25639nu0sCmjh0GLDpf_DQ-cZ0u2TjY2-Cb3AUemPb2vcYj8lBZeqIJ1NfkLfb5evNfbp-vlvdXK_TDaeyT51AEA7RjeGNAcwqyIAK4EzbTEkOpVUVSpOjs9SJzCqNylZCQJWXokRYkIu_veMBnwPGvgg-lljXpsF2iIWieZ4JzkbxbBIHG9AV286HMX0xPWHk5xM3sTR11Zmm9PFf0yAoowq-Abpbbf4</recordid><startdate>19831229</startdate><enddate>19831229</enddate><creator>KEYZER, J. J</creator><creator>DE MONCHY, J. G. R</creator><creator>VAN DOORMAAL, J. J</creator><creator>VAN VOORST VADER, P. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1983-12-29</date><risdate>1983</risdate><volume>309</volume><issue>26</issue><spage>1603</spage><epage>1605</epage><pages>1603-1605</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself.</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>6646186</pmid><doi>10.1056/NEJM198312293092603</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1983-12, Vol.309 (26), p.1603-1605 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80775421 |
| source | MEDLINE; ProQuest Central UK/Ireland |
| subjects | Adult Aged Biological and medical sciences Female Hematologic and hematopoietic diseases Histamine - urine Humans Imidazoles - urine Male Medical sciences Methylhistamines - urine Middle Aged Other diseases. Hematologic involvement in other diseases Urticaria Pigmentosa - diagnosis Urticaria Pigmentosa - urine |
| title | Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites |
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