β-Adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines
Three phenoxypropanolamines with allyl-substitution in the three positions of the benzene ring were studied in the isolated guinea pig atrium and trachea and on heart rate and peripheral vascular resistance in the anaesthetized cat. The ortho- and meta-allyl compounds blocked all responses to isopre...
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| Veröffentlicht in: | European journal of pharmacology 1970, Vol.13 (1), p.59-64 |
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| container_end_page | 64 |
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| container_issue | 1 |
| container_start_page | 59 |
| container_title | European journal of pharmacology |
| container_volume | 13 |
| creator | Åblad, B. Brogård, M. Carlsson, E. Ek, L. |
| description | Three phenoxypropanolamines with allyl-substitution in the three positions of the benzene ring were studied in the isolated guinea pig atrium and trachea and on heart rate and peripheral vascular resistance in the anaesthetized cat. The ortho- and meta-allyl compounds blocked all responses to isopreneline to about an equal degree. The para-allyl derivative however, showed markedly higher affinity to the β-receptors of the heart than to those of vascular and tracheal smooth muscle. |
| doi_str_mv | 10.1016/0014-2999(70)90183-4 |
| format | Article |
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The ortho- and meta-allyl compounds blocked all responses to isopreneline to about an equal degree. The para-allyl derivative however, showed markedly higher affinity to the β-receptors of the heart than to those of vascular and tracheal smooth muscle.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(70)90183-4</identifier><identifier>PMID: 4395676</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Amino Alcohols - pharmacology ; Animals ; Atrium, guinea pig ; Cats ; Guinea pig atrium ; Guinea Pigs ; Heart - drug effects ; Heart Atria - drug effects ; Heart Rate - drug effects ; Heart rate, cat ; In Vitro Techniques ; Isoproterenol - antagonists & inhibitors ; Muscle Contraction - drug effects ; Peripheral vascular resistance, cat ; Phenols - pharmacology ; Phenoxypropanolamines ; Sympatholytics - pharmacology ; Trachea - drug effects ; Trachea, guinea pig ; Vascular Resistance - drug effects ; β-Adrenergic blockers</subject><ispartof>European journal of pharmacology, 1970, Vol.13 (1), p.59-64</ispartof><rights>1970</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-5823f134477ecdb2dddf442b9a66bb8387e499e4be81d43d4933b0e3bb9a52813</citedby><cites>FETCH-LOGICAL-c272t-5823f134477ecdb2dddf442b9a66bb8387e499e4be81d43d4933b0e3bb9a52813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(70)90183-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4395676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Åblad, B.</creatorcontrib><creatorcontrib>Brogård, M.</creatorcontrib><creatorcontrib>Carlsson, E.</creatorcontrib><creatorcontrib>Ek, L.</creatorcontrib><title>β-Adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Three phenoxypropanolamines with allyl-substitution in the three positions of the benzene ring were studied in the isolated guinea pig atrium and trachea and on heart rate and peripheral vascular resistance in the anaesthetized cat. The ortho- and meta-allyl compounds blocked all responses to isopreneline to about an equal degree. The para-allyl derivative however, showed markedly higher affinity to the β-receptors of the heart than to those of vascular and tracheal smooth muscle.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Amino Alcohols - pharmacology</subject><subject>Animals</subject><subject>Atrium, guinea pig</subject><subject>Cats</subject><subject>Guinea pig atrium</subject><subject>Guinea Pigs</subject><subject>Heart - drug effects</subject><subject>Heart Atria - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>Heart rate, cat</subject><subject>In Vitro Techniques</subject><subject>Isoproterenol - antagonists & inhibitors</subject><subject>Muscle Contraction - drug effects</subject><subject>Peripheral vascular resistance, cat</subject><subject>Phenols - pharmacology</subject><subject>Phenoxypropanolamines</subject><subject>Sympatholytics - pharmacology</subject><subject>Trachea - drug effects</subject><subject>Trachea, guinea pig</subject><subject>Vascular Resistance - drug effects</subject><subject>β-Adrenergic blockers</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOxDAQRS0EWpaFPwApFYIi4FfiuEFCiJeERAMVhRXbEzBk42A7iP0tPoRvIsuuKKmmuGfmag5C-wSfEEzKU4wJz6mU8kjgY4lJxXK-gaakEjLHgtBNNP1DttFOjK8Y40LSYoImnMmiFOUUPX1_5ec2QAfh2ZksgIE--ZDp1ps31z1nffA9hOQgZr7J0ksAyOq2XbR5HHRMLg0JbNa_QOc_F0u47nxbz10HcRdtNXUbYW89Z-jx6vLh4ia_u7--vTi_yw0VNOVFRVlDGOdCgLGaWmsbzqmWdVlqXbFKAJcSuIaKWM4sl4xpDEyPREErwmbocHV3rH8fICY1d9FA29Yd-CGqCgvByoKNIF-BJvgYAzSqD25eh4UiWC2dqqUwtRSmBFa_ThUf1w7W9wc9B_u3tJY45merHMYnPxwEFY2DzoB1o8-krHf_F_wAOiqItg</recordid><startdate>1970</startdate><enddate>1970</enddate><creator>Åblad, B.</creator><creator>Brogård, M.</creator><creator>Carlsson, E.</creator><creator>Ek, L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1970</creationdate><title>β-Adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines</title><author>Åblad, B. ; Brogård, M. ; Carlsson, E. ; Ek, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-5823f134477ecdb2dddf442b9a66bb8387e499e4be81d43d4933b0e3bb9a52813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Amino Alcohols - pharmacology</topic><topic>Animals</topic><topic>Atrium, guinea pig</topic><topic>Cats</topic><topic>Guinea pig atrium</topic><topic>Guinea Pigs</topic><topic>Heart - drug effects</topic><topic>Heart Atria - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>Heart rate, cat</topic><topic>In Vitro Techniques</topic><topic>Isoproterenol - antagonists & inhibitors</topic><topic>Muscle Contraction - drug effects</topic><topic>Peripheral vascular resistance, cat</topic><topic>Phenols - pharmacology</topic><topic>Phenoxypropanolamines</topic><topic>Sympatholytics - pharmacology</topic><topic>Trachea - drug effects</topic><topic>Trachea, guinea pig</topic><topic>Vascular Resistance - drug effects</topic><topic>β-Adrenergic blockers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Åblad, B.</creatorcontrib><creatorcontrib>Brogård, M.</creatorcontrib><creatorcontrib>Carlsson, E.</creatorcontrib><creatorcontrib>Ek, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Åblad, B.</au><au>Brogård, M.</au><au>Carlsson, E.</au><au>Ek, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-Adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1970</date><risdate>1970</risdate><volume>13</volume><issue>1</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Three phenoxypropanolamines with allyl-substitution in the three positions of the benzene ring were studied in the isolated guinea pig atrium and trachea and on heart rate and peripheral vascular resistance in the anaesthetized cat. The ortho- and meta-allyl compounds blocked all responses to isopreneline to about an equal degree. The para-allyl derivative however, showed markedly higher affinity to the β-receptors of the heart than to those of vascular and tracheal smooth muscle.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4395676</pmid><doi>10.1016/0014-2999(70)90183-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1970, Vol.13 (1), p.59-64 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenergic beta-Antagonists - pharmacology Amino Alcohols - pharmacology Animals Atrium, guinea pig Cats Guinea pig atrium Guinea Pigs Heart - drug effects Heart Atria - drug effects Heart Rate - drug effects Heart rate, cat In Vitro Techniques Isoproterenol - antagonists & inhibitors Muscle Contraction - drug effects Peripheral vascular resistance, cat Phenols - pharmacology Phenoxypropanolamines Sympatholytics - pharmacology Trachea - drug effects Trachea, guinea pig Vascular Resistance - drug effects β-Adrenergic blockers |
| title | β-Adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines |
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