Solid-State Decomposition of Alkoxyfuroic Acids in the Presence of Microcrystalline Cellulose
□ A solid-solid interaction between alkoxyfuroic acids and microcrystalline cellulose has been studied. The decomposition of the mixture differs from that of the drug(s) alone, in that carbon monoxide (not carbon dioxide) is the high-temperature decomposition product. A model is proposed in which in...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1983-10, Vol.72 (10), p.1149-1154 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Carstensen, J.T. Kothari, Rohit C. |
| description | □ A solid-solid interaction between alkoxyfuroic acids and microcrystalline cellulose has been studied. The decomposition of the mixture differs from that of the drug(s) alone, in that carbon monoxide (not carbon dioxide) is the high-temperature decomposition product. A model is proposed in which interaction occurs at contact points. A liquid decomposition product, dissolving part of the alkoxyfuroic acid (to the extent of its solubility) serves as a carrier, so that the number of contact points increases, thus accelerating the reaction. Both the main and ancillary parameters have calculated values that are consistent with the model. |
| doi_str_mv | 10.1002/jps.2600721010 |
| format | Article |
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The decomposition of the mixture differs from that of the drug(s) alone, in that carbon monoxide (not carbon dioxide) is the high-temperature decomposition product. A model is proposed in which interaction occurs at contact points. A liquid decomposition product, dissolving part of the alkoxyfuroic acid (to the extent of its solubility) serves as a carrier, so that the number of contact points increases, thus accelerating the reaction. Both the main and ancillary parameters have calculated values that are consistent with the model.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600721010</identifier><identifier>PMID: 6644561</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Alkoxyfuroic acid-solid-state interactions with microcrystalline cellulose ; Alkoxyfuroic acid—solid-state interactions with microcrystalline cellulose, decomposition model ; Biological and medical sciences ; Cellulose ; Chemistry, Pharmaceutical ; decomposition model ; Decomposition-alkoxyfuroic acids with microcrystalline cellulose ; Decomposition—alkoxyfuroic acids with microcrystalline cellulose, model, solid-state interactions ; Drug Incompatibility ; Drug Stability ; Excipients ; Furans ; General pharmacology ; Medical sciences ; Microcrystalline cellulose-solid-state interactions with alkoxyfuroic acids ; Microcrystalline cellulose—solid-state interactions with alkoxyfuroic acids, decomposition model ; Models, Chemical ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; solid-state interactions ; Temperature</subject><ispartof>Journal of pharmaceutical sciences, 1983-10, Vol.72 (10), p.1149-1154</ispartof><rights>1983 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4560-98c22514392ed0ed905d387a4cec5a891334f6ed5b597fd8cc6c26e71937cab33</citedby><cites>FETCH-LOGICAL-c4560-98c22514392ed0ed905d387a4cec5a891334f6ed5b597fd8cc6c26e71937cab33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600721010$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600721010$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9654109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6644561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carstensen, J.T.</creatorcontrib><creatorcontrib>Kothari, Rohit C.</creatorcontrib><title>Solid-State Decomposition of Alkoxyfuroic Acids in the Presence of Microcrystalline Cellulose</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>□ A solid-solid interaction between alkoxyfuroic acids and microcrystalline cellulose has been studied. The decomposition of the mixture differs from that of the drug(s) alone, in that carbon monoxide (not carbon dioxide) is the high-temperature decomposition product. A model is proposed in which interaction occurs at contact points. A liquid decomposition product, dissolving part of the alkoxyfuroic acid (to the extent of its solubility) serves as a carrier, so that the number of contact points increases, thus accelerating the reaction. Both the main and ancillary parameters have calculated values that are consistent with the model.</description><subject>Alkoxyfuroic acid-solid-state interactions with microcrystalline cellulose</subject><subject>Alkoxyfuroic acid—solid-state interactions with microcrystalline cellulose, decomposition model</subject><subject>Biological and medical sciences</subject><subject>Cellulose</subject><subject>Chemistry, Pharmaceutical</subject><subject>decomposition model</subject><subject>Decomposition-alkoxyfuroic acids with microcrystalline cellulose</subject><subject>Decomposition—alkoxyfuroic acids with microcrystalline cellulose, model, solid-state interactions</subject><subject>Drug Incompatibility</subject><subject>Drug Stability</subject><subject>Excipients</subject><subject>Furans</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Microcrystalline cellulose-solid-state interactions with alkoxyfuroic acids</subject><subject>Microcrystalline cellulose—solid-state interactions with alkoxyfuroic acids, decomposition model</subject><subject>Models, Chemical</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>solid-state interactions</subject><subject>Temperature</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EWsrClRtSDohbyjiO7fhYdWEBLUulLoILslx7IrybxsVOYPvvcZWqiAPiNIf53pvnZ0KeU5hTgOr17S7NKwEgKwoUHpAZ5RWUAqh8SGYZqErGa_WYPEnpFgAEcH5GzoSoay7ojHxbh867cj2YAYsLtGG7C8kPPvRFaItFdxfu9-0Yg7fFwnqXCt8Xw3csVhET9hYP1EdvY7BxnwbTdb7HYoldN3Yh4VPyqDVdwmfHeU4-v31zs3xXXn26fL9cXJU2p4BSNbaqOK2ZqtABOgXcsUaa2qLlplGUsboV6PiGK9m6xlphK4GSKiat2TB2Tl5NvrsYfoyYBr31yeYUpscwJt2AlNnjAM4nMCdOKWKrd9FvTdxrCvrQp8596j99ZsGLo_O42aI74ccC8_7lcW-SNV0bTW99OmFK8JqCypiasF--w_1_juoPq_VfEcpJ69OA9yetiXdaSCa5_nJ9qWGlrr-yG6ovMt9MPObGf3qMOll_-CvnI9pBu-D_9drfRFewOg</recordid><startdate>198310</startdate><enddate>198310</enddate><creator>Carstensen, J.T.</creator><creator>Kothari, Rohit C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198310</creationdate><title>Solid-State Decomposition of Alkoxyfuroic Acids in the Presence of Microcrystalline Cellulose</title><author>Carstensen, J.T. ; Kothari, Rohit C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4560-98c22514392ed0ed905d387a4cec5a891334f6ed5b597fd8cc6c26e71937cab33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Alkoxyfuroic acid-solid-state interactions with microcrystalline cellulose</topic><topic>Alkoxyfuroic acid—solid-state interactions with microcrystalline cellulose, decomposition model</topic><topic>Biological and medical sciences</topic><topic>Cellulose</topic><topic>Chemistry, Pharmaceutical</topic><topic>decomposition model</topic><topic>Decomposition-alkoxyfuroic acids with microcrystalline cellulose</topic><topic>Decomposition—alkoxyfuroic acids with microcrystalline cellulose, model, solid-state interactions</topic><topic>Drug Incompatibility</topic><topic>Drug Stability</topic><topic>Excipients</topic><topic>Furans</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Microcrystalline cellulose-solid-state interactions with alkoxyfuroic acids</topic><topic>Microcrystalline cellulose—solid-state interactions with alkoxyfuroic acids, decomposition model</topic><topic>Models, Chemical</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>solid-state interactions</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carstensen, J.T.</creatorcontrib><creatorcontrib>Kothari, Rohit C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carstensen, J.T.</au><au>Kothari, Rohit C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid-State Decomposition of Alkoxyfuroic Acids in the Presence of Microcrystalline Cellulose</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1983-10</date><risdate>1983</risdate><volume>72</volume><issue>10</issue><spage>1149</spage><epage>1154</epage><pages>1149-1154</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>□ A solid-solid interaction between alkoxyfuroic acids and microcrystalline cellulose has been studied. The decomposition of the mixture differs from that of the drug(s) alone, in that carbon monoxide (not carbon dioxide) is the high-temperature decomposition product. A model is proposed in which interaction occurs at contact points. A liquid decomposition product, dissolving part of the alkoxyfuroic acid (to the extent of its solubility) serves as a carrier, so that the number of contact points increases, thus accelerating the reaction. Both the main and ancillary parameters have calculated values that are consistent with the model.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6644561</pmid><doi>10.1002/jps.2600721010</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1983-10, Vol.72 (10), p.1149-1154 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Alkoxyfuroic acid-solid-state interactions with microcrystalline cellulose Alkoxyfuroic acid—solid-state interactions with microcrystalline cellulose, decomposition model Biological and medical sciences Cellulose Chemistry, Pharmaceutical decomposition model Decomposition-alkoxyfuroic acids with microcrystalline cellulose Decomposition—alkoxyfuroic acids with microcrystalline cellulose, model, solid-state interactions Drug Incompatibility Drug Stability Excipients Furans General pharmacology Medical sciences Microcrystalline cellulose-solid-state interactions with alkoxyfuroic acids Microcrystalline cellulose—solid-state interactions with alkoxyfuroic acids, decomposition model Models, Chemical Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments solid-state interactions Temperature |
| title | Solid-State Decomposition of Alkoxyfuroic Acids in the Presence of Microcrystalline Cellulose |
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