Increased [ 3H]kainic acid binding in the prefrontal cortex in schizophrenia
[ 3H]Kainic acid binding sites were measured post mortem in the putamenand prefrontal cortex areas from 10 control subjects and 12 schizophrenic patients. A 25–50% increase in [ 3H]kainic acid binding was observed in the medial frontal (Brodmann areas 9, 10 and 46) and eye-movement areas (8), but no...
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| Veröffentlicht in: | Neuroscience letters 1983-10, Vol.40 (3), p.245-250 |
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| container_title | Neuroscience letters |
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| creator | Nishikawa, Toru Takashima, Mizuo Toru, Michio |
| description | [
3H]Kainic acid binding sites were measured post mortem in the putamenand prefrontal cortex areas from 10 control subjects and 12 schizophrenic patients. A 25–50% increase in [
3H]kainic acid binding was observed in the medial frontal (Brodmann areas 9, 10 and 46) and eye-movement areas (8), but not in the other regions of schizophrenic brains. No significant correlation between the binding and either age at death, storage of the brains, duration of illness or neuroleptics-free period was observed. These findings suggest that a dysfunction of cortical excitatory amino acidergic transmission may be involved in schizophrenia. |
| doi_str_mv | 10.1016/0304-3940(83)90046-0 |
| format | Article |
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3H]Kainic acid binding sites were measured post mortem in the putamenand prefrontal cortex areas from 10 control subjects and 12 schizophrenic patients. A 25–50% increase in [
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3H]Kainic acid binding sites were measured post mortem in the putamenand prefrontal cortex areas from 10 control subjects and 12 schizophrenic patients. A 25–50% increase in [
3H]kainic acid binding was observed in the medial frontal (Brodmann areas 9, 10 and 46) and eye-movement areas (8), but not in the other regions of schizophrenic brains. No significant correlation between the binding and either age at death, storage of the brains, duration of illness or neuroleptics-free period was observed. These findings suggest that a dysfunction of cortical excitatory amino acidergic transmission may be involved in schizophrenia.</description><subject>[ 3H]kainic acid binding</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brodmann's cytoarchitectonic areas</subject><subject>Female</subject><subject>Frontal Lobe - metabolism</subject><subject>General aspects</subject><subject>Humans</subject><subject>Kainic Acid - metabolism</subject><subject>Kinetics</subject><subject>l-glutamic acid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>prefrontal cortex</subject><subject>putamen</subject><subject>Putamen - metabolism</subject><subject>Pyrrolidines - metabolism</subject><subject>schizophrenia</subject><subject>Schizophrenia - metabolism</subject><subject>Tritium</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRav34Bwo5iOghOul-ZS-CFLVCwYueRJbNZmJX003dTUX99Sa29OhpDu_zDjMPIUcZXGSQiUugwFKqGJzl9FwBMJHCFhlmuRylUsnRNhlukF2yF-MbAPCMswEZCMEEU3xIpvfeBjQRy-Q5oZOXd-O8s4mxrkwK50vnXxPnk3aGySJgFRrfmjqxTWjxqw-inbmfZjEL6J05IDuVqSMeruc-ebq9eRxP0unD3f34eppaKmSb5pRxqbBQjJV5rqiSCGB4WXFOORpVyEyCkt2PRlYUq7wQKBTnAiUTBVK6T05Xexeh-VhibPXcRYt1bTw2y6hzkHLEBXQgW4E2NDF29-tFcHMTvnUGupeoe0O6N6Rzqv8k6r52vN6_LOZYbkpra11-ss5NtKaugvHWxQ2mBAPORIddrTDsXHw6DDpah95i6QLaVpeN-_-OX-aqi-U</recordid><startdate>19831010</startdate><enddate>19831010</enddate><creator>Nishikawa, Toru</creator><creator>Takashima, Mizuo</creator><creator>Toru, Michio</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19831010</creationdate><title>Increased [ 3H]kainic acid binding in the prefrontal cortex in schizophrenia</title><author>Nishikawa, Toru ; Takashima, Mizuo ; Toru, Michio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-834579eb944d889397e00a5df5535ea9b717097016a7f3ef8b6e69556e746be33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>[ 3H]kainic acid binding</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brodmann's cytoarchitectonic areas</topic><topic>Female</topic><topic>Frontal Lobe - metabolism</topic><topic>General aspects</topic><topic>Humans</topic><topic>Kainic Acid - metabolism</topic><topic>Kinetics</topic><topic>l-glutamic acid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>prefrontal cortex</topic><topic>putamen</topic><topic>Putamen - metabolism</topic><topic>Pyrrolidines - metabolism</topic><topic>schizophrenia</topic><topic>Schizophrenia - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishikawa, Toru</creatorcontrib><creatorcontrib>Takashima, Mizuo</creatorcontrib><creatorcontrib>Toru, Michio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishikawa, Toru</au><au>Takashima, Mizuo</au><au>Toru, Michio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased [ 3H]kainic acid binding in the prefrontal cortex in schizophrenia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1983-10-10</date><risdate>1983</risdate><volume>40</volume><issue>3</issue><spage>245</spage><epage>250</epage><pages>245-250</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>[
3H]Kainic acid binding sites were measured post mortem in the putamenand prefrontal cortex areas from 10 control subjects and 12 schizophrenic patients. A 25–50% increase in [
3H]kainic acid binding was observed in the medial frontal (Brodmann areas 9, 10 and 46) and eye-movement areas (8), but not in the other regions of schizophrenic brains. No significant correlation between the binding and either age at death, storage of the brains, duration of illness or neuroleptics-free period was observed. These findings suggest that a dysfunction of cortical excitatory amino acidergic transmission may be involved in schizophrenia.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6646495</pmid><doi>10.1016/0304-3940(83)90046-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1983-10, Vol.40 (3), p.245-250 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80772560 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | [ 3H]kainic acid binding Aged Biological and medical sciences Brodmann's cytoarchitectonic areas Female Frontal Lobe - metabolism General aspects Humans Kainic Acid - metabolism Kinetics l-glutamic acid Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments prefrontal cortex putamen Putamen - metabolism Pyrrolidines - metabolism schizophrenia Schizophrenia - metabolism Tritium |
| title | Increased [ 3H]kainic acid binding in the prefrontal cortex in schizophrenia |
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