Changes in immune function in patients receiving natural leukocyte interferon

Highly purified human lymphoblastoid interferon derived from virus-stimulated Namalwa cells was administered daily by 6-h i.v. infusion or i.m. injection to 40 patients with a variety of disseminated malignancies refractory to standard therapy. Each patient received escalating doses of 0.1-50 X 10(6...

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Veröffentlicht in:	Journal of biological response modifiers 1983, Vol.2 (5), p.418-427
Hauptverfasser:	Maluish, A E, Ortaldo, J R, Sherwin, S A, Oldham, R K, Herberman, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytotoxicity, Immunologic Humans Infusions, Parenteral Injections, Intramuscular Interferon Type I - immunology Interferon Type I - therapeutic use Killer Cells, Natural - immunology Monocytes - immunology Neoplasms - immunology Neoplasms - therapy
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Zusammenfassung:	Highly purified human lymphoblastoid interferon derived from virus-stimulated Namalwa cells was administered daily by 6-h i.v. infusion or i.m. injection to 40 patients with a variety of disseminated malignancies refractory to standard therapy. Each patient received escalating doses of 0.1-50 X 10(6) U for up to 5 weeks. Extensive monitoring for changes in various immune functions revealed no sustained elevation in natural killer cell activity, elevated monocyte-mediated antitumor cytostatic activity in approximately 30% of the patients, and depressed lymphoproliferative responses to mitogens and mixed leukocyte culture.
ISSN:	0732-6580