Influence of Ionic Strength on Rectal Absorption of Gentamicin Sulfate in the Presence and Absence of Sodium Salicylate
□ The rectal absorption of gentamicin sulfate in rats, both in the presence and absence of sodium salicylate, was facilitated by the use of high ionic strength aqueous formulations. The relative order of effectiveness in promoting gentamicin absorption was sodium dihydrogen phosphate≃sodium chloride...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1983-10, Vol.72 (10), p.1134-1137 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Fix, Joseph A. Leppert, Paula S. Porter, Patricia A. Caldwell, Larry J. |
| description | □ The rectal absorption of gentamicin sulfate in rats, both in the presence and absence of sodium salicylate, was facilitated by the use of high ionic strength aqueous formulations. The relative order of effectiveness in promoting gentamicin absorption was sodium dihydrogen phosphate≃sodium chloride >>potassium chloride, indicating a preferential effect of sodium ions. The increased gentamicin bioavailability in response to sodium salicylate adjuvant activity appeared to be independent of and additive to the increased gentamicin absorption due to high ionic strength conditions. The inability of sorbitol to increase gentamicin bioavailability above control levels indicated that elevated osmotic pressure was not a major determinant of rectal gentamicin absorption. |
| doi_str_mv | 10.1002/jps.2600721006 |
| format | Article |
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The relative order of effectiveness in promoting gentamicin absorption was sodium dihydrogen phosphate≃sodium chloride >>potassium chloride, indicating a preferential effect of sodium ions. The increased gentamicin bioavailability in response to sodium salicylate adjuvant activity appeared to be independent of and additive to the increased gentamicin absorption due to high ionic strength conditions. The inability of sorbitol to increase gentamicin bioavailability above control levels indicated that elevated osmotic pressure was not a major determinant of rectal gentamicin absorption.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600721006</identifier><identifier>PMID: 6644557</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Absorption ; Absorption, rectal—gentamicin, sodium salicylate adjuvant, effect of ionic strength and specificity ; Animals ; Biological and medical sciences ; Biological Availability ; effect of ionic strength and specificity ; General pharmacology ; Gentamicin-rectal absorption ; Gentamicins - metabolism ; Gentamicin—rectal absorption, effect of ionic strength and specificity, sodium salicylate adjuvant ; Intestinal Absorption - drug effects ; Male ; Medical sciences ; Osmolar Concentration ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; rectal absorption of gentamicin ; rectal-gentamicin ; Rectum - metabolism ; Sodium Salicylate - pharmacology ; sodium salicylate adjuvant ; Sodium salicylate-as adjuvant ; Sodium salicylate—as adjuvant, rectal absorption of gentamicin, effect of ionic strength and specificity ; Sorbitol - pharmacology</subject><ispartof>Journal of pharmaceutical sciences, 1983-10, Vol.72 (10), p.1134-1137</ispartof><rights>1983 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4566-2b1d5f98dfc2288d3cef3e1180aebea681f9efa4ec9e3e1c1e95662a68180e043</citedby><cites>FETCH-LOGICAL-c4566-2b1d5f98dfc2288d3cef3e1180aebea681f9efa4ec9e3e1c1e95662a68180e043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600721006$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600721006$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9654106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6644557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fix, Joseph A.</creatorcontrib><creatorcontrib>Leppert, Paula S.</creatorcontrib><creatorcontrib>Porter, Patricia A.</creatorcontrib><creatorcontrib>Caldwell, Larry J.</creatorcontrib><title>Influence of Ionic Strength on Rectal Absorption of Gentamicin Sulfate in the Presence and Absence of Sodium Salicylate</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>□ The rectal absorption of gentamicin sulfate in rats, both in the presence and absence of sodium salicylate, was facilitated by the use of high ionic strength aqueous formulations. The relative order of effectiveness in promoting gentamicin absorption was sodium dihydrogen phosphate≃sodium chloride >>potassium chloride, indicating a preferential effect of sodium ions. The increased gentamicin bioavailability in response to sodium salicylate adjuvant activity appeared to be independent of and additive to the increased gentamicin absorption due to high ionic strength conditions. The inability of sorbitol to increase gentamicin bioavailability above control levels indicated that elevated osmotic pressure was not a major determinant of rectal gentamicin absorption.</description><subject>Absorption</subject><subject>Absorption, rectal—gentamicin, sodium salicylate adjuvant, effect of ionic strength and specificity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>effect of ionic strength and specificity</subject><subject>General pharmacology</subject><subject>Gentamicin-rectal absorption</subject><subject>Gentamicins - metabolism</subject><subject>Gentamicin—rectal absorption, effect of ionic strength and specificity, sodium salicylate adjuvant</subject><subject>Intestinal Absorption - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Osmolar Concentration</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>rectal absorption of gentamicin</subject><subject>rectal-gentamicin</subject><subject>Rectum - metabolism</subject><subject>Sodium Salicylate - pharmacology</subject><subject>sodium salicylate adjuvant</subject><subject>Sodium salicylate-as adjuvant</subject><subject>Sodium salicylate—as adjuvant, rectal absorption of gentamicin, effect of ionic strength and specificity</subject><subject>Sorbitol - pharmacology</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAUxi0EGmXsyg3JB8QtxXZiJzlOG-s6TWMiMI6W6zwzD8cpdsLof4-7lCIO00623_t9n-3vIfSGkjklhH24W8c5E4SULB3FMzSjnJFMEFo-R7MEsCznRf0SvYrxjiSCcH6ADoQoCs7LGbpfeuNG8Bpwb_Cy91bjZgjgvw-3uPf4M-hBOXy8in1YDzZVErYAP6jOautxMzqjBsBpO9wCvg4QH8yUb7eiv8ZN39qxw41yVm9cErxGL4xyEY526yH6evbxy8l5dvlpsTw5vsx0wYXI2Iq23NRVazRjVdXmGkwOlFZEwQqUqKipwagCdA2prinUSca2jYoAKfJD9H7yXYf-5whxkJ2NGpxTHvoxyoqUJRUlTeB8AnXoYwxg5DrYToWNpERuk5Ypafkv6SR4u3MeVx20e3wXbeq_2_VV1MqZoLy2cY_Vghf0waaesHvrYPPEpfLiuvnvCdmktXGA33utCj-kKPOSy29XC3l6Vl-x-vxC3iS-mnhIif-yEGTUdjui1oY0Z9n29rHf_gEXlLmd</recordid><startdate>198310</startdate><enddate>198310</enddate><creator>Fix, Joseph A.</creator><creator>Leppert, Paula S.</creator><creator>Porter, Patricia A.</creator><creator>Caldwell, Larry J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198310</creationdate><title>Influence of Ionic Strength on Rectal Absorption of Gentamicin Sulfate in the Presence and Absence of Sodium Salicylate</title><author>Fix, Joseph A. ; Leppert, Paula S. ; Porter, Patricia A. ; Caldwell, Larry J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4566-2b1d5f98dfc2288d3cef3e1180aebea681f9efa4ec9e3e1c1e95662a68180e043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Absorption</topic><topic>Absorption, rectal—gentamicin, sodium salicylate adjuvant, effect of ionic strength and specificity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>effect of ionic strength and specificity</topic><topic>General pharmacology</topic><topic>Gentamicin-rectal absorption</topic><topic>Gentamicins - metabolism</topic><topic>Gentamicin—rectal absorption, effect of ionic strength and specificity, sodium salicylate adjuvant</topic><topic>Intestinal Absorption - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Osmolar Concentration</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>rectal absorption of gentamicin</topic><topic>rectal-gentamicin</topic><topic>Rectum - metabolism</topic><topic>Sodium Salicylate - pharmacology</topic><topic>sodium salicylate adjuvant</topic><topic>Sodium salicylate-as adjuvant</topic><topic>Sodium salicylate—as adjuvant, rectal absorption of gentamicin, effect of ionic strength and specificity</topic><topic>Sorbitol - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fix, Joseph A.</creatorcontrib><creatorcontrib>Leppert, Paula S.</creatorcontrib><creatorcontrib>Porter, Patricia A.</creatorcontrib><creatorcontrib>Caldwell, Larry J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fix, Joseph A.</au><au>Leppert, Paula S.</au><au>Porter, Patricia A.</au><au>Caldwell, Larry J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Ionic Strength on Rectal Absorption of Gentamicin Sulfate in the Presence and Absence of Sodium Salicylate</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1983-10</date><risdate>1983</risdate><volume>72</volume><issue>10</issue><spage>1134</spage><epage>1137</epage><pages>1134-1137</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>□ The rectal absorption of gentamicin sulfate in rats, both in the presence and absence of sodium salicylate, was facilitated by the use of high ionic strength aqueous formulations. The relative order of effectiveness in promoting gentamicin absorption was sodium dihydrogen phosphate≃sodium chloride >>potassium chloride, indicating a preferential effect of sodium ions. The increased gentamicin bioavailability in response to sodium salicylate adjuvant activity appeared to be independent of and additive to the increased gentamicin absorption due to high ionic strength conditions. The inability of sorbitol to increase gentamicin bioavailability above control levels indicated that elevated osmotic pressure was not a major determinant of rectal gentamicin absorption.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6644557</pmid><doi>10.1002/jps.2600721006</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Absorption Absorption, rectal—gentamicin, sodium salicylate adjuvant, effect of ionic strength and specificity Animals Biological and medical sciences Biological Availability effect of ionic strength and specificity General pharmacology Gentamicin-rectal absorption Gentamicins - metabolism Gentamicin—rectal absorption, effect of ionic strength and specificity, sodium salicylate adjuvant Intestinal Absorption - drug effects Male Medical sciences Osmolar Concentration Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Inbred Strains rectal absorption of gentamicin rectal-gentamicin Rectum - metabolism Sodium Salicylate - pharmacology sodium salicylate adjuvant Sodium salicylate-as adjuvant Sodium salicylate—as adjuvant, rectal absorption of gentamicin, effect of ionic strength and specificity Sorbitol - pharmacology |
| title | Influence of Ionic Strength on Rectal Absorption of Gentamicin Sulfate in the Presence and Absence of Sodium Salicylate |
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