Hormonal control of heart function and myosin atpase activity
Peak intraventricular pressure and rate of pressure development were lower in hearts from hypophysectomized as compared to normal rats. Treatment of hypophysectomized rats with growth hormone (GH) and thyroxine (T 4) increased heart size, but only T 4 restored hemodynamic function to normal. Ca ++-a...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1970-12, Vol.41 (6), p.1584-1589 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Hjalmarson, A.O.C. Whitfield, C.F. Morgan, H.E. |
| description | Peak intraventricular pressure and rate of pressure development were lower in hearts from hypophysectomized as compared to normal rats. Treatment of hypophysectomized rats with growth hormone (GH) and thyroxine (T
4) increased heart size, but only T
4 restored hemodynamic function to normal. Ca
++-activated ATPase of myosin from hearts of hypophysectomized rats was reduced as compared to myosin from hearts of normal rats. Treatment of hormone-deficient animals with T
4 restored ATPase to normal, but GH was without effect. K
+ and NH
4
+-activated ATPase of myosin did not vary with hormonal status of the animals. These findings indicated that hormonal regulation of cardiac contractility involved changes in the catalytic activity of myosin. |
| doi_str_mv | 10.1016/0006-291X(70)90569-3 |
| format | Article |
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4) increased heart size, but only T
4 restored hemodynamic function to normal. Ca
++-activated ATPase of myosin from hearts of hypophysectomized rats was reduced as compared to myosin from hearts of normal rats. Treatment of hormone-deficient animals with T
4 restored ATPase to normal, but GH was without effect. K
+ and NH
4
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4) increased heart size, but only T
4 restored hemodynamic function to normal. Ca
++-activated ATPase of myosin from hearts of hypophysectomized rats was reduced as compared to myosin from hearts of normal rats. Treatment of hormone-deficient animals with T
4 restored ATPase to normal, but GH was without effect. K
+ and NH
4
+-activated ATPase of myosin did not vary with hormonal status of the animals. These findings indicated that hormonal regulation of cardiac contractility involved changes in the catalytic activity of myosin.</description><subject>Adenosine Triphosphatases - metabolism</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Calcium</subject><subject>Enzyme Activation</subject><subject>Female</subject><subject>Growth Hormone - pharmacology</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Heart Function Tests</subject><subject>Hypophysectomy</subject><subject>Muscle Proteins</subject><subject>Myocardium - enzymology</subject><subject>Perfusion</subject><subject>Pituitary Gland - physiology</subject><subject>Potassium</subject><subject>Quaternary Ammonium Compounds</subject><subject>Rats</subject><subject>Thyroxine - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AQxxdRaq1-A4WcRA_R2ewjyUFBilqh4EXB27LZB64k2bq7KfTbm9ri0dMM_B_D_BA6x3CDAfNbAOB5UeOPqxKua2C8zskBmmKoIS8w0EM0_bMco5MYvwAwpryeoAktGBAopuhu4UPne9lmyvcp-DbzNvs0MqTMDr1KzveZ7HXWbXx045pWMppMjsLapc0pOrKyjeZsP2fo_enxbb7Il6_PL_OHZa6Kski5ZVYxzImyBIMBqUtObaMbilXDKiJLXunRU9iGYdDMMKBW84pKJoERBWSGLne9q-C_BxOT6FxUpm1lb_wQRQUlL4uSjUa6M6rgYwzGilVwnQwbgUFsqYktErFFIkoQv9QEGWMX-_6h6Yz-C-0xjfr9Tjfjk2tngojKmV4Z7YJRSWjv_j_wAxFGfCY</recordid><startdate>19701224</startdate><enddate>19701224</enddate><creator>Hjalmarson, A.O.C.</creator><creator>Whitfield, C.F.</creator><creator>Morgan, H.E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19701224</creationdate><title>Hormonal control of heart function and myosin atpase activity</title><author>Hjalmarson, A.O.C. ; Whitfield, C.F. ; Morgan, H.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-f5fc5163cf310e0ad764fbdb41cb583a768df5f2fb510d5e504fd684a5a053c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adenosine Triphosphatases - metabolism</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Calcium</topic><topic>Enzyme Activation</topic><topic>Female</topic><topic>Growth Hormone - pharmacology</topic><topic>Heart - drug effects</topic><topic>Heart - physiology</topic><topic>Heart Function Tests</topic><topic>Hypophysectomy</topic><topic>Muscle Proteins</topic><topic>Myocardium - enzymology</topic><topic>Perfusion</topic><topic>Pituitary Gland - physiology</topic><topic>Potassium</topic><topic>Quaternary Ammonium Compounds</topic><topic>Rats</topic><topic>Thyroxine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hjalmarson, A.O.C.</creatorcontrib><creatorcontrib>Whitfield, C.F.</creatorcontrib><creatorcontrib>Morgan, H.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hjalmarson, A.O.C.</au><au>Whitfield, C.F.</au><au>Morgan, H.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal control of heart function and myosin atpase activity</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1970-12-24</date><risdate>1970</risdate><volume>41</volume><issue>6</issue><spage>1584</spage><epage>1589</epage><pages>1584-1589</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Peak intraventricular pressure and rate of pressure development were lower in hearts from hypophysectomized as compared to normal rats. Treatment of hypophysectomized rats with growth hormone (GH) and thyroxine (T
4) increased heart size, but only T
4 restored hemodynamic function to normal. Ca
++-activated ATPase of myosin from hearts of hypophysectomized rats was reduced as compared to myosin from hearts of normal rats. Treatment of hormone-deficient animals with T
4 restored ATPase to normal, but GH was without effect. K
+ and NH
4
+-activated ATPase of myosin did not vary with hormonal status of the animals. These findings indicated that hormonal regulation of cardiac contractility involved changes in the catalytic activity of myosin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4250302</pmid><doi>10.1016/0006-291X(70)90569-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1970-12, Vol.41 (6), p.1584-1589 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adenosine Triphosphatases - metabolism Animals Blood Pressure Calcium Enzyme Activation Female Growth Hormone - pharmacology Heart - drug effects Heart - physiology Heart Function Tests Hypophysectomy Muscle Proteins Myocardium - enzymology Perfusion Pituitary Gland - physiology Potassium Quaternary Ammonium Compounds Rats Thyroxine - pharmacology |
| title | Hormonal control of heart function and myosin atpase activity |
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