Effects of orotic acid on purine and lipoprotein metabolism in man

In the present study, it was demonstrated that orotic acid, a normal intermediate in pyrimidine synthesis, inhibits purine biosynthesis de novo in normal man. This was associated with depletion of erythrocyte 5-phosphoribosyl-1-pyrophosphate (PP-ribose-P) content. Orotic acid had no inhibitory effec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1970-12, Vol.19 (12), p.1025-1035
Hauptverfasser:	Kelley, William N., Greene, Martin L., Fox, Irving H., Rosenbloom, Frederick M., Levy, Robert I., Seegmiller, J.Edwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - metabolism Administration, Oral Carbon Isotopes Cholesterol - blood Diphosphates - blood Erythrocytes - analysis Erythrocytes - enzymology Erythrocytes - metabolism Glycine - metabolism Guanine Humans Kidney - drug effects Lipoproteins - blood Lipoproteins - metabolism Metabolic Clearance Rate - drug effects Nitrogen Orotic Acid - administration & dosage Orotic Acid - pharmacology Purines - biosynthesis Radioisotopes Ribose - blood Transferases - blood Triglycerides - blood Uric Acid - blood Uric Acid - urine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!