Lack of a requirement for idiotype matching: T cells from mice which cannot produce idiotype support idiotype‐positive antibody response
A requirement for idiotype matching was reported such that carrier‐primed T helper cells from mice, which are unable to produce an idiotype (idiotype‐negative) because of genetic reasons or adult anti‐idiotype or neonatal anti‐μ antibody treatment, did not provide helper function for an idiotype‐pos...
Gespeichert in:
| Veröffentlicht in: | European journal of immunology 1983, Vol.13 (10), p.851-855 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 855 |
|---|---|
| container_issue | 10 |
| container_start_page | 851 |
| container_title | European journal of immunology |
| container_volume | 13 |
| creator | Etlinger, Howard M. Heusser, Christoph H. |
| description | A requirement for idiotype matching was reported such that carrier‐primed T helper cells from mice, which are unable to produce an idiotype (idiotype‐negative) because of genetic reasons or adult anti‐idiotype or neonatal anti‐μ antibody treatment, did not provide helper function for an idiotype‐positive antibody response.
We have analyzed the requirement for idiotype matching in the response to phosphorylcholine by using mice which are idiotype‐negative because they were injected with anti‐idiotype antibody shortly after birth. Carrier‐primed T cells from such animals supported idiotype‐positive responses when mixed with normal or primed B cell populations and challenged with appropriate antigen; these responses were quantitatively and qualitatively similar to those obtained with T cells from idiotype‐positive animals. These results demonstrate no requirement for idiotype matching and suggest that the procedure used to establish an idiotype‐negative T cell donor may be decisive in showing a requirement for idiotype matching. |
| doi_str_mv | 10.1002/eji.1830131013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80755915</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80755915</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3243-5d71ed234ff85bf1f4de4063ca4242b4e81b7b374a2867f94737480b6a3ed90c3</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhq2qFWxpr70h-VD1lmUc20ncW4VoAa3EBc6R44y7pkkc7AS0t5574jfySzDa1cKth9GMZp75egn5wmDJAPITvHVLVnFgnCV7RxZM5iwTTLD3ZAHARJarCg7JxxhvAUAVUh2Qg6IAWUm1IP9W2vyh3lJNA97NLmCPw0StD9S1zk-bEWmvJ7N2w-_v9Joa7LpIbfA97Z1B-rB2Zk2NHgY_0TH4dk7JfWecx9GHaZ94-vs4-ugmd49UD5NrfLtJe-Poh4ifyAeru4ifd_6I3Pw8uz49z1ZXvy5Of6wyw3PBM9mWDNucC2sr2VhmRYsCCm60yEXeCKxYUza8FDqvitIqUaa4gqbQHFsFhh-Rb9u56dy7GeNU9y6-_KUH9HOsKyilVEwmcLkFTfAxBrT1GFyvw6ZmUL-IXyfx61fxU8PxbvLc9Nju8Z3aqf51V9fR6M4GPRgX95gS6UEGCVNb7MF1uPnP0vrs8uLNCc-nmKCS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80755915</pqid></control><display><type>article</type><title>Lack of a requirement for idiotype matching: T cells from mice which cannot produce idiotype support idiotype‐positive antibody response</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Etlinger, Howard M. ; Heusser, Christoph H.</creator><creatorcontrib>Etlinger, Howard M. ; Heusser, Christoph H.</creatorcontrib><description>A requirement for idiotype matching was reported such that carrier‐primed T helper cells from mice, which are unable to produce an idiotype (idiotype‐negative) because of genetic reasons or adult anti‐idiotype or neonatal anti‐μ antibody treatment, did not provide helper function for an idiotype‐positive antibody response.
We have analyzed the requirement for idiotype matching in the response to phosphorylcholine by using mice which are idiotype‐negative because they were injected with anti‐idiotype antibody shortly after birth. Carrier‐primed T cells from such animals supported idiotype‐positive responses when mixed with normal or primed B cell populations and challenged with appropriate antigen; these responses were quantitatively and qualitatively similar to those obtained with T cells from idiotype‐positive animals. These results demonstrate no requirement for idiotype matching and suggest that the procedure used to establish an idiotype‐negative T cell donor may be decisive in showing a requirement for idiotype matching.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830131013</identifier><identifier>PMID: 6605859</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antibodies, Anti-Idiotypic - administration & dosage ; Antibodies, Anti-Idiotypic - biosynthesis ; Antibody-Producing Cells - immunology ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cell Count ; Cell interactions ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunobiology ; Immunoglobulin Idiotypes - biosynthesis ; Immunoglobulin Idiotypes - genetics ; Immunoglobulin Idiotypes - immunology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phosphorylcholine - administration & dosage ; Phosphorylcholine - immunology ; T-Lymphocytes - immunology</subject><ispartof>European journal of immunology, 1983, Vol.13 (10), p.851-855</ispartof><rights>Copyright © 1983 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3243-5d71ed234ff85bf1f4de4063ca4242b4e81b7b374a2867f94737480b6a3ed90c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830131013$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830131013$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9432410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6605859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Etlinger, Howard M.</creatorcontrib><creatorcontrib>Heusser, Christoph H.</creatorcontrib><title>Lack of a requirement for idiotype matching: T cells from mice which cannot produce idiotype support idiotype‐positive antibody response</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>A requirement for idiotype matching was reported such that carrier‐primed T helper cells from mice, which are unable to produce an idiotype (idiotype‐negative) because of genetic reasons or adult anti‐idiotype or neonatal anti‐μ antibody treatment, did not provide helper function for an idiotype‐positive antibody response.
We have analyzed the requirement for idiotype matching in the response to phosphorylcholine by using mice which are idiotype‐negative because they were injected with anti‐idiotype antibody shortly after birth. Carrier‐primed T cells from such animals supported idiotype‐positive responses when mixed with normal or primed B cell populations and challenged with appropriate antigen; these responses were quantitatively and qualitatively similar to those obtained with T cells from idiotype‐positive animals. These results demonstrate no requirement for idiotype matching and suggest that the procedure used to establish an idiotype‐negative T cell donor may be decisive in showing a requirement for idiotype matching.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - administration & dosage</subject><subject>Antibodies, Anti-Idiotypic - biosynthesis</subject><subject>Antibody-Producing Cells - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Cell interactions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>Immunoglobulin Idiotypes - biosynthesis</subject><subject>Immunoglobulin Idiotypes - genetics</subject><subject>Immunoglobulin Idiotypes - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Phosphorylcholine - administration & dosage</subject><subject>Phosphorylcholine - immunology</subject><subject>T-Lymphocytes - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qFWxpr70h-VD1lmUc20ncW4VoAa3EBc6R44y7pkkc7AS0t5574jfySzDa1cKth9GMZp75egn5wmDJAPITvHVLVnFgnCV7RxZM5iwTTLD3ZAHARJarCg7JxxhvAUAVUh2Qg6IAWUm1IP9W2vyh3lJNA97NLmCPw0StD9S1zk-bEWmvJ7N2w-_v9Joa7LpIbfA97Z1B-rB2Zk2NHgY_0TH4dk7JfWecx9GHaZ94-vs4-ugmd49UD5NrfLtJe-Poh4ifyAeru4ifd_6I3Pw8uz49z1ZXvy5Of6wyw3PBM9mWDNucC2sr2VhmRYsCCm60yEXeCKxYUza8FDqvitIqUaa4gqbQHFsFhh-Rb9u56dy7GeNU9y6-_KUH9HOsKyilVEwmcLkFTfAxBrT1GFyvw6ZmUL-IXyfx61fxU8PxbvLc9Nju8Z3aqf51V9fR6M4GPRgX95gS6UEGCVNb7MF1uPnP0vrs8uLNCc-nmKCS</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Etlinger, Howard M.</creator><creator>Heusser, Christoph H.</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Lack of a requirement for idiotype matching: T cells from mice which cannot produce idiotype support idiotype‐positive antibody response</title><author>Etlinger, Howard M. ; Heusser, Christoph H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3243-5d71ed234ff85bf1f4de4063ca4242b4e81b7b374a2867f94737480b6a3ed90c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - administration & dosage</topic><topic>Antibodies, Anti-Idiotypic - biosynthesis</topic><topic>Antibody-Producing Cells - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Cell interactions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunobiology</topic><topic>Immunoglobulin Idiotypes - biosynthesis</topic><topic>Immunoglobulin Idiotypes - genetics</topic><topic>Immunoglobulin Idiotypes - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Phosphorylcholine - administration & dosage</topic><topic>Phosphorylcholine - immunology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Etlinger, Howard M.</creatorcontrib><creatorcontrib>Heusser, Christoph H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Etlinger, Howard M.</au><au>Heusser, Christoph H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of a requirement for idiotype matching: T cells from mice which cannot produce idiotype support idiotype‐positive antibody response</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1983</date><risdate>1983</risdate><volume>13</volume><issue>10</issue><spage>851</spage><epage>855</epage><pages>851-855</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>A requirement for idiotype matching was reported such that carrier‐primed T helper cells from mice, which are unable to produce an idiotype (idiotype‐negative) because of genetic reasons or adult anti‐idiotype or neonatal anti‐μ antibody treatment, did not provide helper function for an idiotype‐positive antibody response.
We have analyzed the requirement for idiotype matching in the response to phosphorylcholine by using mice which are idiotype‐negative because they were injected with anti‐idiotype antibody shortly after birth. Carrier‐primed T cells from such animals supported idiotype‐positive responses when mixed with normal or primed B cell populations and challenged with appropriate antigen; these responses were quantitatively and qualitatively similar to those obtained with T cells from idiotype‐positive animals. These results demonstrate no requirement for idiotype matching and suggest that the procedure used to establish an idiotype‐negative T cell donor may be decisive in showing a requirement for idiotype matching.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>6605859</pmid><doi>10.1002/eji.1830131013</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1983, Vol.13 (10), p.851-855 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80755915 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Antibodies, Anti-Idiotypic - administration & dosage Antibodies, Anti-Idiotypic - biosynthesis Antibody-Producing Cells - immunology B-Lymphocytes - immunology Biological and medical sciences Cell Count Cell interactions Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunoglobulin Idiotypes - biosynthesis Immunoglobulin Idiotypes - genetics Immunoglobulin Idiotypes - immunology Mice Mice, Inbred BALB C Mice, Nude Phosphorylcholine - administration & dosage Phosphorylcholine - immunology T-Lymphocytes - immunology |
| title | Lack of a requirement for idiotype matching: T cells from mice which cannot produce idiotype support idiotype‐positive antibody response |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T18%3A19%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lack%20of%20a%20requirement%20for%20idiotype%20matching:%20T%20cells%20from%20mice%20which%20cannot%20produce%20idiotype%20support%20idiotype%E2%80%90positive%20antibody%20response&rft.jtitle=European%20journal%20of%20immunology&rft.au=Etlinger,%20Howard%20M.&rft.date=1983&rft.volume=13&rft.issue=10&rft.spage=851&rft.epage=855&rft.pages=851-855&rft.issn=0014-2980&rft.eissn=1521-4141&rft.coden=EJIMAF&rft_id=info:doi/10.1002/eji.1830131013&rft_dat=%3Cproquest_cross%3E80755915%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80755915&rft_id=info:pmid/6605859&rfr_iscdi=true |