The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin
Anti‐idiotypic antibodies were raised in rabbits to three monoclonal mouse autoantithyroglobulins. Of the idiotypes recognized, one was unique to that monoclonal, while the other two showed evidence of sharing idiotopes with other monoclonal anti‐thyroglobulin (TG) idiotypes, the IgM idiotype in par...
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| Veröffentlicht in: | European journal of immunology 1983, Vol.13 (11), p.942-947 |
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| container_title | European journal of immunology |
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| creator | Male, David Pryce, Gareth Quartey‐Papafio, Ruby Roitt, Ivan |
| description | Anti‐idiotypic antibodies were raised in rabbits to three monoclonal mouse autoantithyroglobulins. Of the idiotypes recognized, one was unique to that monoclonal, while the other two showed evidence of sharing idiotopes with other monoclonal anti‐thyroglobulin (TG) idiotypes, the IgM idiotype in particular being found on nearly half of the hybridomas studied. Two of the idiotypes could be detected in the sera of mice with experimental allergic thyroiditis (EAT), but they constituted only a very small percentage of the total anti‐TG present. In spite of its low levels in EAT mice the D8 idiotype could be induced by injection of anti‐idiotype and TG and in this case it constituted up to 20% of the anti‐TG activity in individual mice, showing a strain‐related association between the idiotype and autoanti‐TG. |
| doi_str_mv | 10.1002/eji.1830131114 |
| format | Article |
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Of the idiotypes recognized, one was unique to that monoclonal, while the other two showed evidence of sharing idiotopes with other monoclonal anti‐thyroglobulin (TG) idiotypes, the IgM idiotype in particular being found on nearly half of the hybridomas studied. Two of the idiotypes could be detected in the sera of mice with experimental allergic thyroiditis (EAT), but they constituted only a very small percentage of the total anti‐TG present. In spite of its low levels in EAT mice the D8 idiotype could be induced by injection of anti‐idiotype and TG and in this case it constituted up to 20% of the anti‐TG activity in individual mice, showing a strain‐related association between the idiotype and autoanti‐TG.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830131114</identifier><identifier>PMID: 6605864</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Animals ; Antibodies, Anti-Idiotypic - analysis ; Autoantibodies - analysis ; Autoantibodies - biosynthesis ; Autoantibodies - immunology ; Autoimmune Diseases - genetics ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Cross Reactions ; Endocrinopathies ; Immunoglobulin Idiotypes - analysis ; Immunoglobulin Idiotypes - genetics ; Immunoglobulin Idiotypes - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Rabbits ; Thyroglobulin - immunology ; Thyroid. Thyroid axis (diseases) ; Thyroiditis - genetics ; Thyroiditis - immunology</subject><ispartof>European journal of immunology, 1983, Vol.13 (11), p.942-947</ispartof><rights>Copyright © 1983 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3694-2c98b47baed5a082449d220ff33f635e33c5d54b8569ed1267d3e870b7c513963</citedby><cites>FETCH-LOGICAL-c3694-2c98b47baed5a082449d220ff33f635e33c5d54b8569ed1267d3e870b7c513963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830131114$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830131114$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9545309$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6605864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Male, David</creatorcontrib><creatorcontrib>Pryce, Gareth</creatorcontrib><creatorcontrib>Quartey‐Papafio, Ruby</creatorcontrib><creatorcontrib>Roitt, Ivan</creatorcontrib><title>The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Anti‐idiotypic antibodies were raised in rabbits to three monoclonal mouse autoantithyroglobulins. Of the idiotypes recognized, one was unique to that monoclonal, while the other two showed evidence of sharing idiotopes with other monoclonal anti‐thyroglobulin (TG) idiotypes, the IgM idiotype in particular being found on nearly half of the hybridomas studied. Two of the idiotypes could be detected in the sera of mice with experimental allergic thyroiditis (EAT), but they constituted only a very small percentage of the total anti‐TG present. In spite of its low levels in EAT mice the D8 idiotype could be induced by injection of anti‐idiotype and TG and in this case it constituted up to 20% of the anti‐TG activity in individual mice, showing a strain‐related association between the idiotype and autoanti‐TG.</description><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - analysis</subject><subject>Autoantibodies - analysis</subject><subject>Autoantibodies - biosynthesis</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmune Diseases - genetics</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Cross Reactions</subject><subject>Endocrinopathies</subject><subject>Immunoglobulin Idiotypes - analysis</subject><subject>Immunoglobulin Idiotypes - genetics</subject><subject>Immunoglobulin Idiotypes - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred CBA</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Rabbits</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis - genetics</subject><subject>Thyroiditis - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EKqWwsiFlQGwt5_gj8YiqAkWVWMocOfaFukrjYidC_e9J1aqwMd3p7nf3nh4htxQmFCB9xLWb0JwBZZRSfkaGVKR0zCmn52QIQPk4VTlckqsY1wCgpFADMpASRC75kCyWK0y8MV0I2Ji-rRKLlWvQJs463-62GBPfJLprvW5aV3rr-knrk43vIibtahf8Z-3LrnbNNbmodB3x5lhH5ON5tpy-jhfvL_Pp02JsmFS9IaPykmelRis05CnnyqYpVBVjlWQCGTPCCl7mQiq0NJWZZZhnUGZGUKYkG5GHw99t8F8dxrbYuGiwrnWDvasih0wITlUPTg6gCT7GgFWxDW6jw66gUOzjK_r4it_4-oO74-eu3KA94ce8-v39ca-j0XUVdGNcPGFKcMFgr6sO2LercfePaDF7m_-x8AOulYgh</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Male, David</creator><creator>Pryce, Gareth</creator><creator>Quartey‐Papafio, Ruby</creator><creator>Roitt, Ivan</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin</title><author>Male, David ; Pryce, Gareth ; Quartey‐Papafio, Ruby ; Roitt, Ivan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3694-2c98b47baed5a082449d220ff33f635e33c5d54b8569ed1267d3e870b7c513963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - analysis</topic><topic>Autoantibodies - analysis</topic><topic>Autoantibodies - biosynthesis</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmune Diseases - genetics</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Cross Reactions</topic><topic>Endocrinopathies</topic><topic>Immunoglobulin Idiotypes - analysis</topic><topic>Immunoglobulin Idiotypes - genetics</topic><topic>Immunoglobulin Idiotypes - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred CBA</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Rabbits</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis - genetics</topic><topic>Thyroiditis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Male, David</creatorcontrib><creatorcontrib>Pryce, Gareth</creatorcontrib><creatorcontrib>Quartey‐Papafio, Ruby</creatorcontrib><creatorcontrib>Roitt, Ivan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Male, David</au><au>Pryce, Gareth</au><au>Quartey‐Papafio, Ruby</au><au>Roitt, Ivan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1983</date><risdate>1983</risdate><volume>13</volume><issue>11</issue><spage>942</spage><epage>947</epage><pages>942-947</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>Anti‐idiotypic antibodies were raised in rabbits to three monoclonal mouse autoantithyroglobulins. Of the idiotypes recognized, one was unique to that monoclonal, while the other two showed evidence of sharing idiotopes with other monoclonal anti‐thyroglobulin (TG) idiotypes, the IgM idiotype in particular being found on nearly half of the hybridomas studied. Two of the idiotypes could be detected in the sera of mice with experimental allergic thyroiditis (EAT), but they constituted only a very small percentage of the total anti‐TG present. In spite of its low levels in EAT mice the D8 idiotype could be induced by injection of anti‐idiotype and TG and in this case it constituted up to 20% of the anti‐TG activity in individual mice, showing a strain‐related association between the idiotype and autoanti‐TG.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>6605864</pmid><doi>10.1002/eji.1830131114</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1983, Vol.13 (11), p.942-947 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80755419 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antibodies, Anti-Idiotypic - analysis Autoantibodies - analysis Autoantibodies - biosynthesis Autoantibodies - immunology Autoimmune Diseases - genetics Autoimmune Diseases - immunology Biological and medical sciences Cross Reactions Endocrinopathies Immunoglobulin Idiotypes - analysis Immunoglobulin Idiotypes - genetics Immunoglobulin Idiotypes - immunology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred CBA Non tumoral diseases. Target tissue resistance. Benign neoplasms Rabbits Thyroglobulin - immunology Thyroid. Thyroid axis (diseases) Thyroiditis - genetics Thyroiditis - immunology |
| title | The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin |
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