Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia
Adenosine was administered intravenously to 17 patients undergoing intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88 micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and depressed atrioventricular (AV) nodal conduction. These effects were less than 20 sec in d...
Gespeichert in:
Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1983-12, Vol.68 (6), p.1254-1263 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1263 |
---|---|
container_issue | 6 |
container_start_page | 1254 |
container_title | Circulation (New York, N.Y.) |
container_volume | 68 |
creator | DIMARCO, J. P SELLERS, T. D BERNE, R. M WEST, G. A BELARDINELLI, L |
description | Adenosine was administered intravenously to 17 patients undergoing intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88 micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and depressed atrioventricular (AV) nodal conduction. These effects were less than 20 sec in duration and were not influenced by muscarinic blockade with atropine (0.02 to 0.03 mg/kg). Adenosine at this dose had no effect on antegrade conduction over accessory pathways in patients with Wolff-Parkinson-White syndrome. No independent hemodynamic effects were observed. In six patients, adenosine was administered intravenously during stimulation-induced paroxysmal supraventricular tachycardia. In the five patients in whom the reentry loop of their tachycardia included the AV node, adenosine at a mean dose of 83 +/- 35 micrograms/kg (+/- SD) terminated their tachycardia within 20 sec after peripheral intravenous injection. The dose of adenosine required to terminate these tachycardias did not produce manifest sinus node suppression, and sinus rhythm promptly resumed in all patients. Adenosine did not terminate either supraventricular tachycardia due to intra-atrial reentry or atrial flutter, but did produce transient AV block during these arrhythmias. Our findings demonstrate that the human sinus and AV nodes are sensitive to physiologic doses of adenosine and that adenosine may be used safely and effectively to terminate acute episodes of supraventricular tachycardia that involve the AV node in the reentry pathway. |
doi_str_mv | 10.1161/01.cir.68.6.1254 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80751421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80751421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4344-ab623ae868e5bb8ac4ce38d5ecebdefd9a0245bc23b0db32d3cb75ac6322eda03</originalsourceid><addsrcrecordid>eNo9kM1r3DAQxUVpSTdp770UfCi92dW3vb2FpW0CgUJpz2I0GmdVbMuR7JL97-uQJadh5v3eg3mMfRC8EcKKL1w0GHNju8Y2Qhr9iu2EkbrWRu1fsx3nfF-3Ssq37LKUv9tqVWsu2IW1mndtu2MP14GmVOJEXysaCJec5uOpxDSk-4gV9f12KxVMoVqOlGGmddnua6GqT7laKI9xgiVO99UMOT2eyghDVdY5wz-alhxxHWDjAI8nhBwivGNvehgKvT_PK_bn-7ffh5v67ueP28P1XY1aaV2Dt1IBdbYj430HqJFUFwwh-UB92AOX2niUyvPglQwKfWsA7fYtBeDqin1-zp1zelipLG6MBWkYYKK0Ftfx1ggtxQbyZxBzKiVT7-YcR8gnJ7h7atlx4Q63v5ztnHVPLW-Wj-fs1Y8UXgznWjf901mHgjD0GSaM5QXba9PK1qj_KliJ-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80751421</pqid></control><display><type>article</type><title>Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>DIMARCO, J. P ; SELLERS, T. D ; BERNE, R. M ; WEST, G. A ; BELARDINELLI, L</creator><creatorcontrib>DIMARCO, J. P ; SELLERS, T. D ; BERNE, R. M ; WEST, G. A ; BELARDINELLI, L</creatorcontrib><description>Adenosine was administered intravenously to 17 patients undergoing intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88 micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and depressed atrioventricular (AV) nodal conduction. These effects were less than 20 sec in duration and were not influenced by muscarinic blockade with atropine (0.02 to 0.03 mg/kg). Adenosine at this dose had no effect on antegrade conduction over accessory pathways in patients with Wolff-Parkinson-White syndrome. No independent hemodynamic effects were observed. In six patients, adenosine was administered intravenously during stimulation-induced paroxysmal supraventricular tachycardia. In the five patients in whom the reentry loop of their tachycardia included the AV node, adenosine at a mean dose of 83 +/- 35 micrograms/kg (+/- SD) terminated their tachycardia within 20 sec after peripheral intravenous injection. The dose of adenosine required to terminate these tachycardias did not produce manifest sinus node suppression, and sinus rhythm promptly resumed in all patients. Adenosine did not terminate either supraventricular tachycardia due to intra-atrial reentry or atrial flutter, but did produce transient AV block during these arrhythmias. Our findings demonstrate that the human sinus and AV nodes are sensitive to physiologic doses of adenosine and that adenosine may be used safely and effectively to terminate acute episodes of supraventricular tachycardia that involve the AV node in the reentry pathway.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.68.6.1254</identifier><identifier>PMID: 6640877</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adenosine - administration & dosage ; Adenosine - therapeutic use ; Adult ; Aged ; Antiarythmic agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiac Pacing, Artificial ; Cardiovascular system ; Depression, Chemical ; Dose-Response Relationship, Drug ; Electrocardiography ; Electrophysiology ; Female ; Heart Conduction System - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Tachycardia, Paroxysmal - drug therapy ; Time Factors</subject><ispartof>Circulation (New York, N.Y.), 1983-12, Vol.68 (6), p.1254-1263</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4344-ab623ae868e5bb8ac4ce38d5ecebdefd9a0245bc23b0db32d3cb75ac6322eda03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9457275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6640877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DIMARCO, J. P</creatorcontrib><creatorcontrib>SELLERS, T. D</creatorcontrib><creatorcontrib>BERNE, R. M</creatorcontrib><creatorcontrib>WEST, G. A</creatorcontrib><creatorcontrib>BELARDINELLI, L</creatorcontrib><title>Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Adenosine was administered intravenously to 17 patients undergoing intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88 micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and depressed atrioventricular (AV) nodal conduction. These effects were less than 20 sec in duration and were not influenced by muscarinic blockade with atropine (0.02 to 0.03 mg/kg). Adenosine at this dose had no effect on antegrade conduction over accessory pathways in patients with Wolff-Parkinson-White syndrome. No independent hemodynamic effects were observed. In six patients, adenosine was administered intravenously during stimulation-induced paroxysmal supraventricular tachycardia. In the five patients in whom the reentry loop of their tachycardia included the AV node, adenosine at a mean dose of 83 +/- 35 micrograms/kg (+/- SD) terminated their tachycardia within 20 sec after peripheral intravenous injection. The dose of adenosine required to terminate these tachycardias did not produce manifest sinus node suppression, and sinus rhythm promptly resumed in all patients. Adenosine did not terminate either supraventricular tachycardia due to intra-atrial reentry or atrial flutter, but did produce transient AV block during these arrhythmias. Our findings demonstrate that the human sinus and AV nodes are sensitive to physiologic doses of adenosine and that adenosine may be used safely and effectively to terminate acute episodes of supraventricular tachycardia that involve the AV node in the reentry pathway.</description><subject>Adenosine - administration & dosage</subject><subject>Adenosine - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Antiarythmic agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiovascular system</subject><subject>Depression, Chemical</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrocardiography</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Heart Conduction System - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Tachycardia, Paroxysmal - drug therapy</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1r3DAQxUVpSTdp770UfCi92dW3vb2FpW0CgUJpz2I0GmdVbMuR7JL97-uQJadh5v3eg3mMfRC8EcKKL1w0GHNju8Y2Qhr9iu2EkbrWRu1fsx3nfF-3Ssq37LKUv9tqVWsu2IW1mndtu2MP14GmVOJEXysaCJec5uOpxDSk-4gV9f12KxVMoVqOlGGmddnua6GqT7laKI9xgiVO99UMOT2eyghDVdY5wz-alhxxHWDjAI8nhBwivGNvehgKvT_PK_bn-7ffh5v67ueP28P1XY1aaV2Dt1IBdbYj430HqJFUFwwh-UB92AOX2niUyvPglQwKfWsA7fYtBeDqin1-zp1zelipLG6MBWkYYKK0Ftfx1ggtxQbyZxBzKiVT7-YcR8gnJ7h7atlx4Q63v5ztnHVPLW-Wj-fs1Y8UXgznWjf901mHgjD0GSaM5QXba9PK1qj_KliJ-w</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>DIMARCO, J. P</creator><creator>SELLERS, T. D</creator><creator>BERNE, R. M</creator><creator>WEST, G. A</creator><creator>BELARDINELLI, L</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198312</creationdate><title>Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia</title><author>DIMARCO, J. P ; SELLERS, T. D ; BERNE, R. M ; WEST, G. A ; BELARDINELLI, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4344-ab623ae868e5bb8ac4ce38d5ecebdefd9a0245bc23b0db32d3cb75ac6322eda03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adenosine - administration & dosage</topic><topic>Adenosine - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Antiarythmic agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiovascular system</topic><topic>Depression, Chemical</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrocardiography</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Heart Conduction System - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Tachycardia, Paroxysmal - drug therapy</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DIMARCO, J. P</creatorcontrib><creatorcontrib>SELLERS, T. D</creatorcontrib><creatorcontrib>BERNE, R. M</creatorcontrib><creatorcontrib>WEST, G. A</creatorcontrib><creatorcontrib>BELARDINELLI, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DIMARCO, J. P</au><au>SELLERS, T. D</au><au>BERNE, R. M</au><au>WEST, G. A</au><au>BELARDINELLI, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1983-12</date><risdate>1983</risdate><volume>68</volume><issue>6</issue><spage>1254</spage><epage>1263</epage><pages>1254-1263</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Adenosine was administered intravenously to 17 patients undergoing intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88 micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and depressed atrioventricular (AV) nodal conduction. These effects were less than 20 sec in duration and were not influenced by muscarinic blockade with atropine (0.02 to 0.03 mg/kg). Adenosine at this dose had no effect on antegrade conduction over accessory pathways in patients with Wolff-Parkinson-White syndrome. No independent hemodynamic effects were observed. In six patients, adenosine was administered intravenously during stimulation-induced paroxysmal supraventricular tachycardia. In the five patients in whom the reentry loop of their tachycardia included the AV node, adenosine at a mean dose of 83 +/- 35 micrograms/kg (+/- SD) terminated their tachycardia within 20 sec after peripheral intravenous injection. The dose of adenosine required to terminate these tachycardias did not produce manifest sinus node suppression, and sinus rhythm promptly resumed in all patients. Adenosine did not terminate either supraventricular tachycardia due to intra-atrial reentry or atrial flutter, but did produce transient AV block during these arrhythmias. Our findings demonstrate that the human sinus and AV nodes are sensitive to physiologic doses of adenosine and that adenosine may be used safely and effectively to terminate acute episodes of supraventricular tachycardia that involve the AV node in the reentry pathway.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>6640877</pmid><doi>10.1161/01.cir.68.6.1254</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0009-7322 |
ispartof | Circulation (New York, N.Y.), 1983-12, Vol.68 (6), p.1254-1263 |
issn | 0009-7322 1524-4539 |
language | eng |
recordid | cdi_proquest_miscellaneous_80751421 |
source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
subjects | Adenosine - administration & dosage Adenosine - therapeutic use Adult Aged Antiarythmic agents Biological and medical sciences Blood Pressure - drug effects Cardiac Pacing, Artificial Cardiovascular system Depression, Chemical Dose-Response Relationship, Drug Electrocardiography Electrophysiology Female Heart Conduction System - drug effects Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Tachycardia, Paroxysmal - drug therapy Time Factors |
title | Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T23%3A55%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adenosine:%20electrophysiologic%20effects%20and%20therapeutic%20use%20for%20terminating%20paroxysmal%20supraventricular%20tachycardia&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=DIMARCO,%20J.%20P&rft.date=1983-12&rft.volume=68&rft.issue=6&rft.spage=1254&rft.epage=1263&rft.pages=1254-1263&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.cir.68.6.1254&rft_dat=%3Cproquest_cross%3E80751421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80751421&rft_id=info:pmid/6640877&rfr_iscdi=true |