Studies on Synthetic Sweetening Agents. XVIII. Metabolism of Sodium Cyclamate. (7). Dicyclohexylamine, a Metabolite of Sodium Cyclamate in Rabbits and Rats
Dicyclohexylamine (DCHA), a metabolite of sodium cyclamate (CHS-Na), was identified by gas liquid chromatography (GLC) and thin-layer chromatography (TLC) from the urine of rabbits and rats following repeated oral administration of CHS-Na. The urinary excretions (% of the dose) of DCHA in rabbits an...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1983/06/25, Vol.31(6), pp.2079-2084 |
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| creator | SUENAGA, AYAKA WADA, TERUMI ICHIBAGASE, HISASHI |
| description | Dicyclohexylamine (DCHA), a metabolite of sodium cyclamate (CHS-Na), was identified by gas liquid chromatography (GLC) and thin-layer chromatography (TLC) from the urine of rabbits and rats following repeated oral administration of CHS-Na. The urinary excretions (% of the dose) of DCHA in rabbits and rats receiving CHS-Na were 0.041×10-3 and 0.143×10-3%, respectively. Moreover, the metabolic fate of DCHA was investigated in rabbits and rats. The urinary and fecal excretions of unchanged DCHA were relatively small in both rabbits and rats receiving oral or intravenous administration of DCHA. In addition, DCHA was suggested to be primarily metabolized by oxidative reaction in the hepatic 10000×g supernatant. Thus, it may be due to further metabolism of the produced DCHA that only a small amount of DCHA is excreted in the urine after repeated oral administration of CHS-Na to rabbits and rats. |
| doi_str_mv | 10.1248/cpb.31.2079 |
| format | Article |
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The urinary and fecal excretions of unchanged DCHA were relatively small in both rabbits and rats receiving oral or intravenous administration of DCHA. In addition, DCHA was suggested to be primarily metabolized by oxidative reaction in the hepatic 10000×g supernatant. Thus, it may be due to further metabolism of the produced DCHA that only a small amount of DCHA is excreted in the urine after repeated oral administration of CHS-Na to rabbits and rats.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.31.2079</identifier><identifier>PMID: 6196135</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Cyclamates - metabolism ; Cyclohexylamines - metabolism ; Male ; metabolism ; Rabbits ; Rats ; Rats, Inbred Strains ; Species Specificity ; Sweetening Agents - metabolism</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1983/06/25, Vol.31(6), pp.2079-2084</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4779-11aeac9fe88b2867c24206f683f302f4f295730242da4835733b0365da5a03e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6196135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUENAGA, AYAKA</creatorcontrib><creatorcontrib>WADA, TERUMI</creatorcontrib><creatorcontrib>ICHIBAGASE, HISASHI</creatorcontrib><title>Studies on Synthetic Sweetening Agents. 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Thus, it may be due to further metabolism of the produced DCHA that only a small amount of DCHA is excreted in the urine after repeated oral administration of CHS-Na to rabbits and rats.</description><subject>Animals</subject><subject>Cyclamates - metabolism</subject><subject>Cyclohexylamines - metabolism</subject><subject>Male</subject><subject>metabolism</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Species Specificity</subject><subject>Sweetening Agents - metabolism</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV-L1DAUxYMo67j65LMQEMRFW_O3aR6X2VUHVgRHxbeQtrczGdp0tknR-Sx-WVNmGEF8SQ73_O7hwkHoOSU5ZaJ8V--rnNOcEaUfoAXlQmWSMf4QLQghOmO84I_RkxB2hDBJFL9AFwXVBeVygX6v49Q4CHjweH3wcQvR1Xj9EyCCd36DrzfgY8jxj--r1SrHnyDaauhc6PHQ4vXQuKnHy0Pd2d5GyPFrdZXjG1enybCFX4c0dx7eYnvejPC_Tew8_mKrysWArW-SjuEpetTaLsCz03-Jvr2__br8mN19_rBaXt9ltVBKZ5RasLVuoSwrVhaqZoKRoi1K3nLCWtEyLVVSgjVWlDxpXhFeyMZKSzhQfoleHXP343A_QYimd6GGrrMehimYkihJdCET-PIfcDdMo0-3GSqk1kJIQhL15kjV4xDCCK3Zj66348FQYubCTCrMcGrmwhL94pQ5VT00Z_bUUPJvjv4uRLuBs2_HVFQHcxbVspzziuMzx_61t3Y04PkfwYinRg</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>SUENAGA, AYAKA</creator><creator>WADA, TERUMI</creator><creator>ICHIBAGASE, HISASHI</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Studies on Synthetic Sweetening Agents. XVIII. Metabolism of Sodium Cyclamate. (7). 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XVIII. Metabolism of Sodium Cyclamate. (7). Dicyclohexylamine, a Metabolite of Sodium Cyclamate in Rabbits and Rats</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1983</date><risdate>1983</risdate><volume>31</volume><issue>6</issue><spage>2079</spage><epage>2084</epage><pages>2079-2084</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Dicyclohexylamine (DCHA), a metabolite of sodium cyclamate (CHS-Na), was identified by gas liquid chromatography (GLC) and thin-layer chromatography (TLC) from the urine of rabbits and rats following repeated oral administration of CHS-Na. The urinary excretions (% of the dose) of DCHA in rabbits and rats receiving CHS-Na were 0.041×10-3 and 0.143×10-3%, respectively. Moreover, the metabolic fate of DCHA was investigated in rabbits and rats. The urinary and fecal excretions of unchanged DCHA were relatively small in both rabbits and rats receiving oral or intravenous administration of DCHA. In addition, DCHA was suggested to be primarily metabolized by oxidative reaction in the hepatic 10000×g supernatant. Thus, it may be due to further metabolism of the produced DCHA that only a small amount of DCHA is excreted in the urine after repeated oral administration of CHS-Na to rabbits and rats.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>6196135</pmid><doi>10.1248/cpb.31.2079</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1983/06/25, Vol.31(6), pp.2079-2084 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Cyclamates - metabolism Cyclohexylamines - metabolism Male metabolism Rabbits Rats Rats, Inbred Strains Species Specificity Sweetening Agents - metabolism |
| title | Studies on Synthetic Sweetening Agents. XVIII. Metabolism of Sodium Cyclamate. (7). Dicyclohexylamine, a Metabolite of Sodium Cyclamate in Rabbits and Rats |
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