In vitro interactions of TNO6 with human plasma
The ability of TNO6 to react with human plasma was investigated by in vitro incubation of plasma or plasma fractions with injectable TNO6. HPLC, ultrafiltration and flameless atomic absorption spectrophotometry were used to separate the platinum-containing chemical species and to measure the platinu...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1983, Vol.11 (3), p.177-181 |
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| container_title | Cancer chemotherapy and pharmacology |
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| creator | HECQUET, B ADENIS, L DEMAILLE, A |
| description | The ability of TNO6 to react with human plasma was investigated by in vitro incubation of plasma or plasma fractions with injectable TNO6. HPLC, ultrafiltration and flameless atomic absorption spectrophotometry were used to separate the platinum-containing chemical species and to measure the platinum content. The initial concentration of TNO6 in plasma declines very rapidly. The kinetics of the loss of initial TNO6 is very different from that of cisplatin loss. Most of the TNO6 is bound more quickly to proteins, while a little is transformed to less reactive or nonreactive platinum species. The level of final nonreactive platinum species depends on the particular plasma concerned. In addition, the reactivity of TNO6 towards proteins is very sensitive to Cl- concentration. The usefulness of HPLC for the study of TNO6 kinetics is demonstrated. |
| doi_str_mv | 10.1007/BF00254200 |
| format | Article |
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HPLC, ultrafiltration and flameless atomic absorption spectrophotometry were used to separate the platinum-containing chemical species and to measure the platinum content. The initial concentration of TNO6 in plasma declines very rapidly. The kinetics of the loss of initial TNO6 is very different from that of cisplatin loss. Most of the TNO6 is bound more quickly to proteins, while a little is transformed to less reactive or nonreactive platinum species. The level of final nonreactive platinum species depends on the particular plasma concerned. In addition, the reactivity of TNO6 towards proteins is very sensitive to Cl- concentration. The usefulness of HPLC for the study of TNO6 kinetics is demonstrated.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF00254200</identifier><identifier>PMID: 6685579</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Cisplatin - metabolism ; Humans ; In Vitro Techniques ; Kinetics ; Medical sciences ; Organoplatinum Compounds - blood ; Organoplatinum Compounds - metabolism ; Pharmacology. 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HPLC, ultrafiltration and flameless atomic absorption spectrophotometry were used to separate the platinum-containing chemical species and to measure the platinum content. The initial concentration of TNO6 in plasma declines very rapidly. The kinetics of the loss of initial TNO6 is very different from that of cisplatin loss. Most of the TNO6 is bound more quickly to proteins, while a little is transformed to less reactive or nonreactive platinum species. The level of final nonreactive platinum species depends on the particular plasma concerned. In addition, the reactivity of TNO6 towards proteins is very sensitive to Cl- concentration. The usefulness of HPLC for the study of TNO6 kinetics is demonstrated.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Cisplatin - metabolism</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Organoplatinum Compounds - blood</subject><subject>Organoplatinum Compounds - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasma - metabolism</subject><subject>Protein Binding</subject><subject>Spectrophotometry, Atomic</subject><subject>Ultrafiltration</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAYRS0EKqWwsCN5QAxIoZ_f8QgVhUoVXcocOcZWjfIodgLi3xPUCKY73HPvcBC6JHBHANT8YQlABacAR2hKOKMZ5JwdoykwzjOhgJ-is5TeAYATxiZoImUuhNJTNF81-DN0scWh6Vw0tgttk3Dr8fZlI_FX6HZ419emwfvKpNqcoxNvquQuxpyh1-XjdvGcrTdPq8X9OrOUyi7zXlBFvSJMOw_KS0u54cxZMFIbYbUljCoBsqSilAPnpQdNrPCs9J4KNkM3h999bD96l7qiDsm6qjKNa_tU5DCscw0DeHsAbWxTis4X-xhqE78LAsWvneLfzgBfja99Wbu3P3TUMfTXY2-SNZWPprEh_WGa8cGrZD-eLGlo</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>HECQUET, B</creator><creator>ADENIS, L</creator><creator>DEMAILLE, A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>In vitro interactions of TNO6 with human plasma</title><author>HECQUET, B ; ADENIS, L ; DEMAILLE, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-ff5272f7139ef07f6c24a43ec0a69a5c9c1327506b25b6f71f6f091c5f3bff253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Cisplatin - metabolism</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Organoplatinum Compounds - blood</topic><topic>Organoplatinum Compounds - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasma - metabolism</topic><topic>Protein Binding</topic><topic>Spectrophotometry, Atomic</topic><topic>Ultrafiltration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HECQUET, B</creatorcontrib><creatorcontrib>ADENIS, L</creatorcontrib><creatorcontrib>DEMAILLE, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HECQUET, B</au><au>ADENIS, L</au><au>DEMAILLE, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro interactions of TNO6 with human plasma</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1983</date><risdate>1983</risdate><volume>11</volume><issue>3</issue><spage>177</spage><epage>181</epage><pages>177-181</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>The ability of TNO6 to react with human plasma was investigated by in vitro incubation of plasma or plasma fractions with injectable TNO6. HPLC, ultrafiltration and flameless atomic absorption spectrophotometry were used to separate the platinum-containing chemical species and to measure the platinum content. The initial concentration of TNO6 in plasma declines very rapidly. The kinetics of the loss of initial TNO6 is very different from that of cisplatin loss. Most of the TNO6 is bound more quickly to proteins, while a little is transformed to less reactive or nonreactive platinum species. The level of final nonreactive platinum species depends on the particular plasma concerned. In addition, the reactivity of TNO6 towards proteins is very sensitive to Cl- concentration. The usefulness of HPLC for the study of TNO6 kinetics is demonstrated.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6685579</pmid><doi>10.1007/BF00254200</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0344-5704 |
| ispartof | Cancer chemotherapy and pharmacology, 1983, Vol.11 (3), p.177-181 |
| issn | 0344-5704 1432-0843 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Antineoplastic agents Biological and medical sciences Chemotherapy Cisplatin - metabolism Humans In Vitro Techniques Kinetics Medical sciences Organoplatinum Compounds - blood Organoplatinum Compounds - metabolism Pharmacology. Drug treatments Plasma - metabolism Protein Binding Spectrophotometry, Atomic Ultrafiltration |
| title | In vitro interactions of TNO6 with human plasma |
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