Pyrimidine Derivatives. VII. Structure-Activity Relationship of Hypoglycemic 4-Amino-2-(1-piperazinyl) pyrimidines investigated by the Adaptive Least-Squares Method

Structure-activity studies of 36 hypoglycemic 4-amino-2-(1-piperazinyl)-5, 6-polymethylenepyrimidine derivatives were performed by the adaptive least-squares method. In the analysis, the activity was classified into four groups. The best recognition was obtained with the following equation : L=-0.00...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical & pharmaceutical bulletin 1983/07/25, Vol.31(7), pp.2432-2437
Hauptverfasser:	SEKIYA, TETSUO, HATA, SHUNSUKE, YAMADA, SHUNICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(1-piperazinyl)-5, 6, 7, 8-tetrahydroquinazoline Chemical reactivity Chemistry Exact sciences and technology Hypoglycemic Agents Organic chemistry Piperazines - pharmacology Pyrimidines - pharmacology Reactivity and mechanisms Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!