Formation of a supramolecular complex is involved in the reconstitution of basement membrane components
Basement membrane macromolecules, including type IV collagen, laminin, and heparan sulfate proteoglycan, do not aggregate when incubated alone. Rather, precipitation occurs in the presence of equimolar amounts of laminin and type IV collagen but variable amounts of heparan sulfate proteoglycan. This...
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| Veröffentlicht in: | Biochemistry (Easton) 1983-10, Vol.22 (21), p.4969-4974 |
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| container_end_page | 4974 |
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| container_issue | 21 |
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| container_title | Biochemistry (Easton) |
| container_volume | 22 |
| creator | Kleinman, Hynda K McGarvey, Mary L Hassell, John R Martin, George R |
| description | Basement membrane macromolecules, including type IV collagen, laminin, and heparan sulfate proteoglycan, do not aggregate when incubated alone. Rather, precipitation occurs in the presence of equimolar amounts of laminin and type IV collagen but variable amounts of heparan sulfate proteoglycan. This interaction requires native laminin and type IV collagen. Heparan sulfate proteoglycan increases the precipitation of laminin particularly in the presence of type IV collagen. Fibronectin does not cause type IV collagen to precipitate. These studies show that the components of basement membrane interact in a highly specific manner and suggest that such interactions may be involved in the deposition of basement membrane in situ. |
| doi_str_mv | 10.1021/bi00290a014 |
| format | Article |
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Cell surface ; Cell structures and functions ; Chondroitin Sulfate Proteoglycans - metabolism ; Collagen - metabolism ; Fibronectins - metabolism ; Fundamental and applied biological sciences. Psychology ; Glycosaminoglycans - metabolism ; Heparan Sulfate Proteoglycans ; Heparitin Sulfate - metabolism ; Kinetics ; Laminin - metabolism ; Macromolecular Substances ; Molecular and cellular biology ; Neoplasms, Experimental - ultrastructure ; Proteoglycans - metabolism ; Rats</subject><ispartof>Biochemistry (Easton), 1983-10, Vol.22 (21), p.4969-4974</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a449t-bc7f896d1320e3a5319211c23eb6d57d8c2cd9c68ccbae6fbf0d2d656936442b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bi00290a014$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bi00290a014$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9432476$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6227336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleinman, Hynda K</creatorcontrib><creatorcontrib>McGarvey, Mary L</creatorcontrib><creatorcontrib>Hassell, John R</creatorcontrib><creatorcontrib>Martin, George R</creatorcontrib><title>Formation of a supramolecular complex is involved in the reconstitution of basement membrane components</title><title>Biochemistry (Easton)</title><addtitle>Biochemistry</addtitle><description>Basement membrane macromolecules, including type IV collagen, laminin, and heparan sulfate proteoglycan, do not aggregate when incubated alone. Rather, precipitation occurs in the presence of equimolar amounts of laminin and type IV collagen but variable amounts of heparan sulfate proteoglycan. This interaction requires native laminin and type IV collagen. Heparan sulfate proteoglycan increases the precipitation of laminin particularly in the presence of type IV collagen. Fibronectin does not cause type IV collagen to precipitate. These studies show that the components of basement membrane interact in a highly specific manner and suggest that such interactions may be involved in the deposition of basement membrane in situ.</description><subject>Animals</subject><subject>Basement Membrane - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cell coat. Cell surface</subject><subject>Cell structures and functions</subject><subject>Chondroitin Sulfate Proteoglycans - metabolism</subject><subject>Collagen - metabolism</subject><subject>Fibronectins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Heparan Sulfate Proteoglycans</subject><subject>Heparitin Sulfate - metabolism</subject><subject>Kinetics</subject><subject>Laminin - metabolism</subject><subject>Macromolecular Substances</subject><subject>Molecular and cellular biology</subject><subject>Neoplasms, Experimental - ultrastructure</subject><subject>Proteoglycans - metabolism</subject><subject>Rats</subject><issn>0006-2960</issn><issn>1520-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1v1DAQhi0EKtvCiTOSDwgOKDD-zPqIVrQgVVBpizhatjOBlDhe7KQq_x6XXVYcOM3H-8xo5iXkGYM3DDh76wcAbsABkw_IiikOjTRGPSQrANANNxoek9NSbmopoZUn5ERz3gqhV-TbecrRzUOaaOqpo2XZZRfTiGEZXaYhxd2Id3QodJhu03iLXU3o_B1pxpCmMg_z8nfau4IRp5lGjD67Cf-Mp6m2yhPyqHdjwaeHeEa-nL-_3nxoLj9ffNy8u2yclGZufGj7tdEdExxQOCWY4YwFLtDrTrXdOvDQmaDXIXiHuvc9dLzTShuhpeRenJGX-727nH4uWGYbhxJwHOs5aSl2Da0CUKqCr_dgyKmUjL3d5SG6_MsysPe22n9srfTzw9rFR-yO7MHHqr846K4EN_b1-zCUI2ak4LK9x5o9NpQZ746yyz-sbkWr7PXV1m6-8q3-pK_stvKv9rwLxd6kJU_Vu_8e-BsDQpyi</recordid><startdate>19831011</startdate><enddate>19831011</enddate><creator>Kleinman, Hynda K</creator><creator>McGarvey, Mary L</creator><creator>Hassell, John R</creator><creator>Martin, George R</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19831011</creationdate><title>Formation of a supramolecular complex is involved in the reconstitution of basement membrane components</title><author>Kleinman, Hynda K ; McGarvey, Mary L ; Hassell, John R ; Martin, George R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a449t-bc7f896d1320e3a5319211c23eb6d57d8c2cd9c68ccbae6fbf0d2d656936442b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Basement Membrane - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cell coat. Cell surface</topic><topic>Cell structures and functions</topic><topic>Chondroitin Sulfate Proteoglycans - metabolism</topic><topic>Collagen - metabolism</topic><topic>Fibronectins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Heparan Sulfate Proteoglycans</topic><topic>Heparitin Sulfate - metabolism</topic><topic>Kinetics</topic><topic>Laminin - metabolism</topic><topic>Macromolecular Substances</topic><topic>Molecular and cellular biology</topic><topic>Neoplasms, Experimental - ultrastructure</topic><topic>Proteoglycans - metabolism</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleinman, Hynda K</creatorcontrib><creatorcontrib>McGarvey, Mary L</creatorcontrib><creatorcontrib>Hassell, John R</creatorcontrib><creatorcontrib>Martin, George R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Easton)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleinman, Hynda K</au><au>McGarvey, Mary L</au><au>Hassell, John R</au><au>Martin, George R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formation of a supramolecular complex is involved in the reconstitution of basement membrane components</atitle><jtitle>Biochemistry (Easton)</jtitle><addtitle>Biochemistry</addtitle><date>1983-10-11</date><risdate>1983</risdate><volume>22</volume><issue>21</issue><spage>4969</spage><epage>4974</epage><pages>4969-4974</pages><issn>0006-2960</issn><eissn>1520-4995</eissn><abstract>Basement membrane macromolecules, including type IV collagen, laminin, and heparan sulfate proteoglycan, do not aggregate when incubated alone. Rather, precipitation occurs in the presence of equimolar amounts of laminin and type IV collagen but variable amounts of heparan sulfate proteoglycan. This interaction requires native laminin and type IV collagen. Heparan sulfate proteoglycan increases the precipitation of laminin particularly in the presence of type IV collagen. Fibronectin does not cause type IV collagen to precipitate. These studies show that the components of basement membrane interact in a highly specific manner and suggest that such interactions may be involved in the deposition of basement membrane in situ.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>6227336</pmid><doi>10.1021/bi00290a014</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemistry (Easton), 1983-10, Vol.22 (21), p.4969-4974 |
| issn | 0006-2960 1520-4995 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Basement Membrane - ultrastructure Biological and medical sciences Cell coat. Cell surface Cell structures and functions Chondroitin Sulfate Proteoglycans - metabolism Collagen - metabolism Fibronectins - metabolism Fundamental and applied biological sciences. Psychology Glycosaminoglycans - metabolism Heparan Sulfate Proteoglycans Heparitin Sulfate - metabolism Kinetics Laminin - metabolism Macromolecular Substances Molecular and cellular biology Neoplasms, Experimental - ultrastructure Proteoglycans - metabolism Rats |
| title | Formation of a supramolecular complex is involved in the reconstitution of basement membrane components |
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