The effects of chronic haloperidol administration on GABA receptor binding

The effect of chronic administration of haloperidol for 30 days and its subsequent withdrawal for 0,4 and 8 days on the binding of [ 3H]-GABA and [ 3H]-muscimol to GABA binding sites in rat brain membranes obtained from six discrete regions of the brain and spinal cord was investigated. The chronic...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1983-08, Vol.19 (2), p.199-204
Hauptverfasser:	Huffman, Ronald D., Ticku, Maharaj K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apomorphine - pharmacology Apomorphine-induced stereotypies Biological and medical sciences Brain - metabolism central nervous system dopamine Dopaminergic supersensitivity Drug Administration Schedule GABA receptor binding gamma -aminobutyric acid gamma-Aminobutyric Acid - metabolism Haloperidol Haloperidol - administration & dosage Haloperidol - pharmacology Humans Kinetics Male Medical sciences Muscimol Muscimol - metabolism Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, GABA-A sensitization Stereotyped Behavior - drug effects Substantia nigra Time Factors
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