The effects of chronic haloperidol administration on GABA receptor binding
The effect of chronic administration of haloperidol for 30 days and its subsequent withdrawal for 0,4 and 8 days on the binding of [ 3H]-GABA and [ 3H]-muscimol to GABA binding sites in rat brain membranes obtained from six discrete regions of the brain and spinal cord was investigated. The chronic...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1983-08, Vol.19 (2), p.199-204 |
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| creator | Huffman, Ronald D. Ticku, Maharaj K. |
| description | The effect of chronic administration of haloperidol for 30 days and its subsequent withdrawal for 0,4 and 8 days on the binding of [
3H]-GABA and [
3H]-muscimol to GABA binding sites in rat brain membranes obtained from six discrete regions of the brain and spinal cord was investigated. The chronic administration of haloperidol resulted in a marked increase in the number of GABA binding sites within the substantia nigra, but did not affect GABA binding sites in other regions of rat brain or spinal cord. The increase in GABA binding sites in the substantia nigra was evident for at least 4 days following termination of haloperidol treatment; however, 8 days following withdrawal from haloperidol, when dopaminergic supersensitivity had become maximally expressed, the number of GABA binding sites in the substantia nigra had declined and was the same as that observed in the control rats. These observations suggest that blockade of dopamine receptors in the striatum by haloperidol results in a compensatory decrease in the activity of the GABAergic strionigral system that leads to an increase in the number of GABA binding sites within the substantia nigra. This increase in the number of GABA binding sites is gradually reversed when dopamine is again allowed to interact with its receptors. |
| doi_str_mv | 10.1016/0091-3057(83)90039-4 |
| format | Article |
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3H]-GABA and [
3H]-muscimol to GABA binding sites in rat brain membranes obtained from six discrete regions of the brain and spinal cord was investigated. The chronic administration of haloperidol resulted in a marked increase in the number of GABA binding sites within the substantia nigra, but did not affect GABA binding sites in other regions of rat brain or spinal cord. The increase in GABA binding sites in the substantia nigra was evident for at least 4 days following termination of haloperidol treatment; however, 8 days following withdrawal from haloperidol, when dopaminergic supersensitivity had become maximally expressed, the number of GABA binding sites in the substantia nigra had declined and was the same as that observed in the control rats. These observations suggest that blockade of dopamine receptors in the striatum by haloperidol results in a compensatory decrease in the activity of the GABAergic strionigral system that leads to an increase in the number of GABA binding sites within the substantia nigra. This increase in the number of GABA binding sites is gradually reversed when dopamine is again allowed to interact with its receptors.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(83)90039-4</identifier><identifier>PMID: 6314387</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Apomorphine - pharmacology ; Apomorphine-induced stereotypies ; Biological and medical sciences ; Brain - metabolism ; central nervous system ; dopamine ; Dopaminergic supersensitivity ; Drug Administration Schedule ; GABA receptor binding ; gamma -aminobutyric acid ; gamma-Aminobutyric Acid - metabolism ; Haloperidol ; Haloperidol - administration & dosage ; Haloperidol - pharmacology ; Humans ; Kinetics ; Male ; Medical sciences ; Muscimol ; Muscimol - metabolism ; Neuropharmacology ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface - drug effects ; Receptors, Cell Surface - metabolism ; Receptors, Dopamine - drug effects ; Receptors, Dopamine - metabolism ; Receptors, GABA-A ; sensitization ; Stereotyped Behavior - drug effects ; Substantia nigra ; Time Factors</subject><ispartof>Pharmacology, biochemistry and behavior, 1983-08, Vol.19 (2), p.199-204</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-357ab99b33e88d14476135fb11d5377658dfcf6c94f4e51c8f2ef9884563cb93</citedby><cites>FETCH-LOGICAL-c483t-357ab99b33e88d14476135fb11d5377658dfcf6c94f4e51c8f2ef9884563cb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(83)90039-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9504317$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6314387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huffman, Ronald D.</creatorcontrib><creatorcontrib>Ticku, Maharaj K.</creatorcontrib><title>The effects of chronic haloperidol administration on GABA receptor binding</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The effect of chronic administration of haloperidol for 30 days and its subsequent withdrawal for 0,4 and 8 days on the binding of [
3H]-GABA and [
3H]-muscimol to GABA binding sites in rat brain membranes obtained from six discrete regions of the brain and spinal cord was investigated. The chronic administration of haloperidol resulted in a marked increase in the number of GABA binding sites within the substantia nigra, but did not affect GABA binding sites in other regions of rat brain or spinal cord. The increase in GABA binding sites in the substantia nigra was evident for at least 4 days following termination of haloperidol treatment; however, 8 days following withdrawal from haloperidol, when dopaminergic supersensitivity had become maximally expressed, the number of GABA binding sites in the substantia nigra had declined and was the same as that observed in the control rats. These observations suggest that blockade of dopamine receptors in the striatum by haloperidol results in a compensatory decrease in the activity of the GABAergic strionigral system that leads to an increase in the number of GABA binding sites within the substantia nigra. This increase in the number of GABA binding sites is gradually reversed when dopamine is again allowed to interact with its receptors.</description><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Apomorphine-induced stereotypies</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>central nervous system</subject><subject>dopamine</subject><subject>Dopaminergic supersensitivity</subject><subject>Drug Administration Schedule</subject><subject>GABA receptor binding</subject><subject>gamma -aminobutyric acid</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Haloperidol</subject><subject>Haloperidol - administration & dosage</subject><subject>Haloperidol - pharmacology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscimol</subject><subject>Muscimol - metabolism</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Cell Surface - drug effects</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Receptors, GABA-A</subject><subject>sensitization</subject><subject>Stereotyped Behavior - drug effects</subject><subject>Substantia nigra</subject><subject>Time Factors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVISZ20_yCFPYTSHjaRPPq8FNyQpg2BXHwXWmkUK6xXrrQO9N93XRsfGxiYwzzvy_AQcsnoNaNM3lBqWAtUqC8avhpKwbT8hMyYVtAKptQpmR2R9-S81hdKKZ9LdUbOJDAOWs3Iw3KFDcaIfqxNjo1flTwk36xcnzdYUsh948I6DamOxY0pD80094vvi6agx82YS9OlIaTh-QN5F11f8eNhX5Dlj7vl7c_28en-1-3isfVcw9iCUK4zpgNArQPjXEkGInaMBQFKSaFD9FF6wyNHwbyOc4xGay4k-M7ABfm8r92U_HuLdbTrVD32vRswb6vVVIHUSr4JMlAgOJ1PIN-DvuRaC0a7KWntyh_LqN2ptjuPdufRarD_VFs-xT4d-rfdGsMxdHA73a8Od1e962Nxg0_1iBlBObAd9m2P4eTsNWGx1SccPIY0GR5tyOn_f_wF_DqYxw</recordid><startdate>198308</startdate><enddate>198308</enddate><creator>Huffman, Ronald D.</creator><creator>Ticku, Maharaj K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198308</creationdate><title>The effects of chronic haloperidol administration on GABA receptor binding</title><author>Huffman, Ronald D. ; Ticku, Maharaj K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-357ab99b33e88d14476135fb11d5377658dfcf6c94f4e51c8f2ef9884563cb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Apomorphine-induced stereotypies</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>central nervous system</topic><topic>dopamine</topic><topic>Dopaminergic supersensitivity</topic><topic>Drug Administration Schedule</topic><topic>GABA receptor binding</topic><topic>gamma -aminobutyric acid</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Haloperidol</topic><topic>Haloperidol - administration & dosage</topic><topic>Haloperidol - pharmacology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscimol</topic><topic>Muscimol - metabolism</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Cell Surface - drug effects</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Receptors, GABA-A</topic><topic>sensitization</topic><topic>Stereotyped Behavior - drug effects</topic><topic>Substantia nigra</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huffman, Ronald D.</creatorcontrib><creatorcontrib>Ticku, Maharaj K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huffman, Ronald D.</au><au>Ticku, Maharaj K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of chronic haloperidol administration on GABA receptor binding</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1983-08</date><risdate>1983</risdate><volume>19</volume><issue>2</issue><spage>199</spage><epage>204</epage><pages>199-204</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The effect of chronic administration of haloperidol for 30 days and its subsequent withdrawal for 0,4 and 8 days on the binding of [
3H]-GABA and [
3H]-muscimol to GABA binding sites in rat brain membranes obtained from six discrete regions of the brain and spinal cord was investigated. The chronic administration of haloperidol resulted in a marked increase in the number of GABA binding sites within the substantia nigra, but did not affect GABA binding sites in other regions of rat brain or spinal cord. The increase in GABA binding sites in the substantia nigra was evident for at least 4 days following termination of haloperidol treatment; however, 8 days following withdrawal from haloperidol, when dopaminergic supersensitivity had become maximally expressed, the number of GABA binding sites in the substantia nigra had declined and was the same as that observed in the control rats. These observations suggest that blockade of dopamine receptors in the striatum by haloperidol results in a compensatory decrease in the activity of the GABAergic strionigral system that leads to an increase in the number of GABA binding sites within the substantia nigra. This increase in the number of GABA binding sites is gradually reversed when dopamine is again allowed to interact with its receptors.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6314387</pmid><doi>10.1016/0091-3057(83)90039-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1983-08, Vol.19 (2), p.199-204 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Apomorphine - pharmacology Apomorphine-induced stereotypies Biological and medical sciences Brain - metabolism central nervous system dopamine Dopaminergic supersensitivity Drug Administration Schedule GABA receptor binding gamma -aminobutyric acid gamma-Aminobutyric Acid - metabolism Haloperidol Haloperidol - administration & dosage Haloperidol - pharmacology Humans Kinetics Male Medical sciences Muscimol Muscimol - metabolism Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, GABA-A sensitization Stereotyped Behavior - drug effects Substantia nigra Time Factors |
| title | The effects of chronic haloperidol administration on GABA receptor binding |
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