Altered intracellular calcium regulation in human colorectal cancers and in normal adjacent mucosa
Intracellular calcium [(Ca2+)i] was measured in human colonic epithelia derived from control mucosa from noncancer patients, from grossly "normal" mucosa taken 10-30 cm proximal to primary colorectal cancers, and from colorectal cancers. (Ca2+)i was measured first in cells bathed by calciu...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1991-08, Vol.51 (16), p.4492-4494 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | EDELSTEIN, P. S THOMPSON, S. M DAVIES, R. J |
| description | Intracellular calcium [(Ca2+)i] was measured in human colonic epithelia derived from control mucosa from noncancer patients, from grossly "normal" mucosa taken 10-30 cm proximal to primary colorectal cancers, and from colorectal cancers. (Ca2+)i was measured first in cells bathed by calcium-free solution and again after adding 1 mM calcium. Compared to control mucosa, (Ca2+)i was 27% lower in cancer cells in the presence of 1 mM extracellular calcium, whereas (Ca2+)i was elevated more than 3-fold in the adjacent "normal" mucosa from cancer patients in both media. These results suggest altered (Ca2+)i levels in malignant cells and the presence of a "field defect" in (Ca2+)i regulation in "normal" colonic mucosa adjacent to colorectal cancers. |
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S ; THOMPSON, S. M ; DAVIES, R. J</creator><creatorcontrib>EDELSTEIN, P. S ; THOMPSON, S. M ; DAVIES, R. J</creatorcontrib><description>Intracellular calcium [(Ca2+)i] was measured in human colonic epithelia derived from control mucosa from noncancer patients, from grossly "normal" mucosa taken 10-30 cm proximal to primary colorectal cancers, and from colorectal cancers. (Ca2+)i was measured first in cells bathed by calcium-free solution and again after adding 1 mM calcium. Compared to control mucosa, (Ca2+)i was 27% lower in cancer cells in the presence of 1 mM extracellular calcium, whereas (Ca2+)i was elevated more than 3-fold in the adjacent "normal" mucosa from cancer patients in both media. These results suggest altered (Ca2+)i levels in malignant cells and the presence of a "field defect" in (Ca2+)i regulation in "normal" colonic mucosa adjacent to colorectal cancers.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 1868472</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; calcium ; Calcium - metabolism ; Colon ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Fluorescent Dyes ; Fura-2 - analogs & derivatives ; Gastroenterology. Liver. Pancreas. Abdomen ; Homeostasis ; Humans ; Intestinal Mucosa - metabolism ; Medical sciences ; Rectal Neoplasms - metabolism ; Rectal Neoplasms - pathology ; Spectrometry, Fluorescence ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 1991-08, Vol.51 (16), p.4492-4494</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4943560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1868472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EDELSTEIN, P. S</creatorcontrib><creatorcontrib>THOMPSON, S. M</creatorcontrib><creatorcontrib>DAVIES, R. J</creatorcontrib><title>Altered intracellular calcium regulation in human colorectal cancers and in normal adjacent mucosa</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Intracellular calcium [(Ca2+)i] was measured in human colonic epithelia derived from control mucosa from noncancer patients, from grossly "normal" mucosa taken 10-30 cm proximal to primary colorectal cancers, and from colorectal cancers. (Ca2+)i was measured first in cells bathed by calcium-free solution and again after adding 1 mM calcium. Compared to control mucosa, (Ca2+)i was 27% lower in cancer cells in the presence of 1 mM extracellular calcium, whereas (Ca2+)i was elevated more than 3-fold in the adjacent "normal" mucosa from cancer patients in both media. These results suggest altered (Ca2+)i levels in malignant cells and the presence of a "field defect" in (Ca2+)i regulation in "normal" colonic mucosa adjacent to colorectal cancers.</description><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Colon</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Fluorescent Dyes</subject><subject>Fura-2 - analogs & derivatives</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Medical sciences</subject><subject>Rectal Neoplasms - metabolism</subject><subject>Rectal Neoplasms - pathology</subject><subject>Spectrometry, Fluorescence</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9Lw0AQxRdRaq1-BGEP4i2wyWSTzbEUtULBi57D7J_alM2m7iYHv71TDF49De_Nj8fMu2DLXILK6rKUl2wphFCZLOvimt2kdCQpcyEXbJGrSpG9ZHrtRxed5V0YIxrn_eQxcoPedFPPo_skPXZDIIAfph4DN4MfojMjesKCcTFxDOcAHobYk4v2SElh5P1khoS37GqPPrm7ea7Yx_PT-2ab7d5eXjfrXXYAIcYsb8DJvRalAqsNCCk1GGzo0KIWugQBubVFjcaCpLcAUZOsG6tVo4CMFXv8zT3F4WtyaWz7Lp0_wuCGKbVK1FCBKv4F8yqvqBxB4P0MTrp3tj3Frsf43c7t0f5h3mOixvaR6ujSH1Y2JchKwA9BxnlM</recordid><startdate>19910815</startdate><enddate>19910815</enddate><creator>EDELSTEIN, P. S</creator><creator>THOMPSON, S. M</creator><creator>DAVIES, R. J</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19910815</creationdate><title>Altered intracellular calcium regulation in human colorectal cancers and in normal adjacent mucosa</title><author>EDELSTEIN, P. S ; THOMPSON, S. M ; DAVIES, R. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h300t-193e5fb0483dbc3055b3ca9868270b43031dd27acd350083aabd2779db8983083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Colon</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Fluorescent Dyes</topic><topic>Fura-2 - analogs & derivatives</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Medical sciences</topic><topic>Rectal Neoplasms - metabolism</topic><topic>Rectal Neoplasms - pathology</topic><topic>Spectrometry, Fluorescence</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EDELSTEIN, P. S</creatorcontrib><creatorcontrib>THOMPSON, S. M</creatorcontrib><creatorcontrib>DAVIES, R. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EDELSTEIN, P. S</au><au>THOMPSON, S. M</au><au>DAVIES, R. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered intracellular calcium regulation in human colorectal cancers and in normal adjacent mucosa</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1991-08-15</date><risdate>1991</risdate><volume>51</volume><issue>16</issue><spage>4492</spage><epage>4494</epage><pages>4492-4494</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Intracellular calcium [(Ca2+)i] was measured in human colonic epithelia derived from control mucosa from noncancer patients, from grossly "normal" mucosa taken 10-30 cm proximal to primary colorectal cancers, and from colorectal cancers. (Ca2+)i was measured first in cells bathed by calcium-free solution and again after adding 1 mM calcium. Compared to control mucosa, (Ca2+)i was 27% lower in cancer cells in the presence of 1 mM extracellular calcium, whereas (Ca2+)i was elevated more than 3-fold in the adjacent "normal" mucosa from cancer patients in both media. These results suggest altered (Ca2+)i levels in malignant cells and the presence of a "field defect" in (Ca2+)i regulation in "normal" colonic mucosa adjacent to colorectal cancers.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>1868472</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1991-08, Vol.51 (16), p.4492-4494 |
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| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences calcium Calcium - metabolism Colon Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Fluorescent Dyes Fura-2 - analogs & derivatives Gastroenterology. Liver. Pancreas. Abdomen Homeostasis Humans Intestinal Mucosa - metabolism Medical sciences Rectal Neoplasms - metabolism Rectal Neoplasms - pathology Spectrometry, Fluorescence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Altered intracellular calcium regulation in human colorectal cancers and in normal adjacent mucosa |
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