Regional cerebral metabolic rate for glucose in beagle dogs of different ages
Regional cerebral metabolic rates for glucose (rCMR glc) were studied in unanesthetized Beagle dogs in five age groups. Significant age-related differences did not occur in the cingulate, pyriform or visual cortices, cerebellar flocculus, corpus callosum, or cerebellar white matter. However, age-rel...
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| Veröffentlicht in: | Neurobiology of aging 1983-01, Vol.4 (2), p.121-126 |
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| creator | London, Edythe D. Ohata, Masahiro Takei, Hidenori French, A.Wayne Rapoport, Stanley I. |
| description | Regional cerebral metabolic rates for glucose (rCMR
glc) were studied in unanesthetized Beagle dogs in five age groups. Significant age-related differences did not occur in the cingulate, pyriform or visual cortices, cerebellar flocculus, corpus callosum, or cerebellar white matter. However, age-related decrements were apparent in 15 of the 22 brain regions examined. The apparent time course of age effect on rCMR
glc varied among the brain regions. Most regions had significantly lower rCMR
glc at 6 years than at 1 year. Decrements of more than 25% were seen in the mammillary bodies, pons, hippocampus, superior colliculus, basis of the midbrain, temporal cortex, geniculate bodies, caudate nucleus, and superior frontal gyrus. There were no age differences in rCMR
glc at 10–12 years compared with 6 years. Senescence-associated decrements (after 6 years) were noted in only 5 regions: the frontal and temporal cortices, mammillary bodies, and areas involved in sensory functions. The results indicate that rCMR
glc in the adult Beagle brain declines by midlife, and continues to decline in some brain regions through senescence. |
| doi_str_mv | 10.1016/0197-4580(83)90035-0 |
| format | Article |
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glc) were studied in unanesthetized Beagle dogs in five age groups. Significant age-related differences did not occur in the cingulate, pyriform or visual cortices, cerebellar flocculus, corpus callosum, or cerebellar white matter. However, age-related decrements were apparent in 15 of the 22 brain regions examined. The apparent time course of age effect on rCMR
glc varied among the brain regions. Most regions had significantly lower rCMR
glc at 6 years than at 1 year. Decrements of more than 25% were seen in the mammillary bodies, pons, hippocampus, superior colliculus, basis of the midbrain, temporal cortex, geniculate bodies, caudate nucleus, and superior frontal gyrus. There were no age differences in rCMR
glc at 10–12 years compared with 6 years. Senescence-associated decrements (after 6 years) were noted in only 5 regions: the frontal and temporal cortices, mammillary bodies, and areas involved in sensory functions. The results indicate that rCMR
glc in the adult Beagle brain declines by midlife, and continues to decline in some brain regions through senescence.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(83)90035-0</identifier><identifier>PMID: 6633781</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>2-Deoxy-D-glucose ; Age Factors ; Aging ; Animals ; Beagle ; Brain - metabolism ; Canine brain ; Cerebral metabolism ; Deoxyglucose - metabolism ; Dogs ; Female ; Glucose - metabolism ; Glucose utilization</subject><ispartof>Neurobiology of aging, 1983-01, Vol.4 (2), p.121-126</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-7a0e3ea637bbb9cd59e2ba582139d24f92b99ec8b50d1b0b517b16b57eda59653</citedby><cites>FETCH-LOGICAL-c388t-7a0e3ea637bbb9cd59e2ba582139d24f92b99ec8b50d1b0b517b16b57eda59653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0197-4580(83)90035-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6633781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>London, Edythe D.</creatorcontrib><creatorcontrib>Ohata, Masahiro</creatorcontrib><creatorcontrib>Takei, Hidenori</creatorcontrib><creatorcontrib>French, A.Wayne</creatorcontrib><creatorcontrib>Rapoport, Stanley I.</creatorcontrib><title>Regional cerebral metabolic rate for glucose in beagle dogs of different ages</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Regional cerebral metabolic rates for glucose (rCMR
glc) were studied in unanesthetized Beagle dogs in five age groups. Significant age-related differences did not occur in the cingulate, pyriform or visual cortices, cerebellar flocculus, corpus callosum, or cerebellar white matter. However, age-related decrements were apparent in 15 of the 22 brain regions examined. The apparent time course of age effect on rCMR
glc varied among the brain regions. Most regions had significantly lower rCMR
glc at 6 years than at 1 year. Decrements of more than 25% were seen in the mammillary bodies, pons, hippocampus, superior colliculus, basis of the midbrain, temporal cortex, geniculate bodies, caudate nucleus, and superior frontal gyrus. There were no age differences in rCMR
glc at 10–12 years compared with 6 years. Senescence-associated decrements (after 6 years) were noted in only 5 regions: the frontal and temporal cortices, mammillary bodies, and areas involved in sensory functions. The results indicate that rCMR
glc in the adult Beagle brain declines by midlife, and continues to decline in some brain regions through senescence.</description><subject>2-Deoxy-D-glucose</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Animals</subject><subject>Beagle</subject><subject>Brain - metabolism</subject><subject>Canine brain</subject><subject>Cerebral metabolism</subject><subject>Deoxyglucose - metabolism</subject><subject>Dogs</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Glucose utilization</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtq3DAUhkVpSCbTvkELWpVm4eTIsixpUyihucCEQEjXQpdjo-KxEskO5O3r6QxZNqvzw3858BHyhcE5A9ZeANOyaoSC74qfaQAuKvhAVkwIVbFGy49k9RY5Iael_AEA2cj2mBy3LedSsRW5e8A-ptEO1GNGlxexxcm6NERPs52QdinTfph9KkjjSB3afkAaUl9o6miIXbcUx4naHssnctTZoeDnw12T31e_Hi9vqs399e3lz03luVJTJS0gR9ty6ZzTPgiNtbNC1YzrUDedrp3W6JUTEJgDJ5h0rHVCYrBCt4Kvybf97lNOzzOWyWxj8TgMdsQ0F6NAchC6fjfIuGxA17vFZh_0OZWSsTNPOW5tfjUMzA632bE0O5ZGcfMPt4Gl9vWwP7sthrfSge_i_9j7uNB4iZhN8RFHjyFm9JMJKf7_wV_B1I5O</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>London, Edythe D.</creator><creator>Ohata, Masahiro</creator><creator>Takei, Hidenori</creator><creator>French, A.Wayne</creator><creator>Rapoport, Stanley I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Regional cerebral metabolic rate for glucose in beagle dogs of different ages</title><author>London, Edythe D. ; Ohata, Masahiro ; Takei, Hidenori ; French, A.Wayne ; Rapoport, Stanley I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-7a0e3ea637bbb9cd59e2ba582139d24f92b99ec8b50d1b0b517b16b57eda59653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>2-Deoxy-D-glucose</topic><topic>Age Factors</topic><topic>Aging</topic><topic>Animals</topic><topic>Beagle</topic><topic>Brain - metabolism</topic><topic>Canine brain</topic><topic>Cerebral metabolism</topic><topic>Deoxyglucose - metabolism</topic><topic>Dogs</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Glucose utilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>London, Edythe D.</creatorcontrib><creatorcontrib>Ohata, Masahiro</creatorcontrib><creatorcontrib>Takei, Hidenori</creatorcontrib><creatorcontrib>French, A.Wayne</creatorcontrib><creatorcontrib>Rapoport, Stanley I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>London, Edythe D.</au><au>Ohata, Masahiro</au><au>Takei, Hidenori</au><au>French, A.Wayne</au><au>Rapoport, Stanley I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cerebral metabolic rate for glucose in beagle dogs of different ages</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>4</volume><issue>2</issue><spage>121</spage><epage>126</epage><pages>121-126</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Regional cerebral metabolic rates for glucose (rCMR
glc) were studied in unanesthetized Beagle dogs in five age groups. Significant age-related differences did not occur in the cingulate, pyriform or visual cortices, cerebellar flocculus, corpus callosum, or cerebellar white matter. However, age-related decrements were apparent in 15 of the 22 brain regions examined. The apparent time course of age effect on rCMR
glc varied among the brain regions. Most regions had significantly lower rCMR
glc at 6 years than at 1 year. Decrements of more than 25% were seen in the mammillary bodies, pons, hippocampus, superior colliculus, basis of the midbrain, temporal cortex, geniculate bodies, caudate nucleus, and superior frontal gyrus. There were no age differences in rCMR
glc at 10–12 years compared with 6 years. Senescence-associated decrements (after 6 years) were noted in only 5 regions: the frontal and temporal cortices, mammillary bodies, and areas involved in sensory functions. The results indicate that rCMR
glc in the adult Beagle brain declines by midlife, and continues to decline in some brain regions through senescence.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6633781</pmid><doi>10.1016/0197-4580(83)90035-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neurobiology of aging, 1983-01, Vol.4 (2), p.121-126 |
| issn | 0197-4580 1558-1497 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 2-Deoxy-D-glucose Age Factors Aging Animals Beagle Brain - metabolism Canine brain Cerebral metabolism Deoxyglucose - metabolism Dogs Female Glucose - metabolism Glucose utilization |
| title | Regional cerebral metabolic rate for glucose in beagle dogs of different ages |
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