Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia

The clinical relevance of cellular drug resistance in children with acute lymphoblastic leukaemia (ALL) is unknown. The relation between in-vitro sensitivity to chemotherapeutic drugs at initial diagnosis and long-term clinical outcome was investigated in 44 children with ALL. The short-term MTT ass...

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Veröffentlicht in:	The Lancet (British edition) 1991-08, Vol.338 (8764), p.399-403
Hauptverfasser:	Pieters, R., Huismans, D.R., Loonen, A.H., Veerman, A.J.P., Hahlen, K., van der Does-van den Berg, A., Wering, E.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Mercaptopurine Acute lymphoblastic leukemia Antineoplastic agents Antineoplastic Agents - pharmacology Asparaginase Asparaginase - pharmacology Biological and medical sciences Chemotherapy Chi-Square Distribution Child Children Children & youth Coloring Agents Daunorubicin Daunorubicin - pharmacology Drug Resistance Drug Screening Assays, Antitumor Female Girls Humans Leukemia Male Medical research Medical sciences Patients Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Prednisolone Prednisolone - pharmacology Prognosis Remission Remission Induction Sensitivity analysis Tetrazolium Salts Thiazoles Thioguanine Thioguanine - pharmacology Tumor Cells, Cultured - drug effects Vincristine Vincristine - pharmacology
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