Neuroprotective effects of stanniocalcin 2 following kainic acid-induced hippocampal degeneration in ICR mice

▶ STC2 attenuates KA-induced neuronal death. ▶ STC2 attenuates KA-induced microglial activation. ▶ STC2 attenuates KA-induced HO-1 expression in the glial cells. ▶ STC2 inhibits expression levels of NO, TNF-α, and IL-1β in LPS-stimulated BV2 cells. Stanniocalcin 2 (STC2), the paralog of STC1, has be...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2010-11, Vol.31 (11), p.2094-2099
Hauptverfasser:	Byun, Jong-Seon, Lee, Jae-Won, Kim, Su Young, Kwon, Kwang Jun, Sohn, Jong-Hee, Lee, Kyunyoung, Oh, Dahlkyun, Kim, Sung-Soo, Chun, Wanjoo, Lee, Hee Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Attenuation Biological and medical sciences BV2 cells Cell Death - drug effects Degeneration Fundamental and applied biological sciences. Psychology Glycoproteins - pharmacology Heme Oxygenase-1 - biosynthesis Hippocampus Hippocampus - metabolism Inhibition Interleukin-1beta - biosynthesis Kainic acid Kainic Acid - antagonists & inhibitors Lipopolysaccharides Male Mice Mice, Inbred ICR Microglia - drug effects Microglia - metabolism Microglial activation Neuroprotective Agents - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - biosynthesis Proteins Stanniocalcin 2 Toxicity Tumor Necrosis Factor-alpha - biosynthesis Vertebrates: endocrinology
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