Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam

Abstract Synapsins (SynI, SynII, SynIII) are a multigene family of synaptic vesicle (SV) phosphoproteins implicated in the regulation of synaptic transmission and plasticity. Synapsin I, II, I/II and I/II/III knockout mice are epileptic and SYN1/2 genes have been identified as major epilepsy suscept...

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Veröffentlicht in:	Neuroscience 2010-11, Vol.171 (1), p.268-283
Hauptverfasser:	Boido, D, Farisello, P, Cesca, F, Ferrea, E, Valtorta, F, Benfenati, F, Baldelli, P
Format:	Artikel
Sprache:	eng
Schlagworte:	4-aminopyridine 4-Aminopyridine - pharmacology Age Aging Analysis of Variance Animals Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral Cortex - physiopathology Disease Models, Animal Drug Interactions Electrodes epilepsy Epilepsy, Tonic-Clonic - genetics Epilepsy, Tonic-Clonic - pathology Evoked Potentials - drug effects Evoked Potentials - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Hippocampus - pathology Hippocampus - physiopathology ictal discharge In Vitro Techniques interictal event Medical sciences Membrane Glycoproteins - metabolism Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mice, Inbred C57BL Mice, Knockout mouse model multi-electrode arrays Nerve Tissue Proteins - metabolism Neurology Neurons - drug effects Neuropharmacology Patch-Clamp Techniques Pharmacology. Drug treatments Piracetam - analogs & derivatives Piracetam - pharmacology Potassium Channel Blockers - pharmacology Synapsins - deficiency Synaptophysin - metabolism Vertebrates: nervous system and sense organs
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