Trans-generational and neonatal humoral immune responses in West Greenland sledge dogs ( Canis familiaris) exposed to organohalogenated environmental contaminants
Previous investigations in the Arctic have suggested OHC (organohalogen contaminant) induced immune toxic effects on e.g. polar bears ( Ursus maritimus). We therefore studied the dietary impact from minke whale blubber ( Balaenoptera acutorostrata), rich in polyunsaturated fatty acids and OHCs, on t...
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| Veröffentlicht in: | The Science of the total environment 2010-11, Vol.408 (23), p.5801-5807 |
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| creator | Sonne, Christian Larsen, Hans Jørgen S. Kirkegaard, Maja Letcher, Robert J. Dietz, Rune |
| description | Previous investigations in the Arctic have suggested OHC (organohalogen contaminant) induced immune toxic effects on
e.g. polar bears (
Ursus maritimus). We therefore studied the dietary impact from minke whale blubber (
Balaenoptera acutorostrata), rich in polyunsaturated fatty acids and OHCs, on the humoral immunity of 7 captive West Greenland sledge dog (
Canis familiaris) bitches and their 4 pups constituting a sentinel model species for polar bears. A control group was composed of 8 bitches and their 5 pups all fed pork (
Suis scrofa) fat. The study included serum IgG measurements (bitches and pups) and specific immune responses towards tetanus toxoid (bitches) and diphtheria toxoid (pups) as well as influenza virus (pups). The analyses showed that IgG concentrations were non-significantly lowest in exposed bitches and pups (t-test: all p
>
0.05). In addition, significant lower antibody response was detected in exposed pups immunized with influenza virus at age 3
months (t-test: both p
<
0.05). No clear group differences were found for tetanus toxoid in bitches and diphtheria toxoid in pups. The results suggest that the humoral immune system of sledge dogs may be suppressed by the dietary blubber composition of OHCs and polyunsaturated fatty acids while a larger follow-up study is recommended in order to investigate this relationship further. |
| doi_str_mv | 10.1016/j.scitotenv.2010.07.076 |
| format | Article |
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e.g. polar bears (
Ursus maritimus). We therefore studied the dietary impact from minke whale blubber (
Balaenoptera acutorostrata), rich in polyunsaturated fatty acids and OHCs, on the humoral immunity of 7 captive West Greenland sledge dog (
Canis familiaris) bitches and their 4 pups constituting a sentinel model species for polar bears. A control group was composed of 8 bitches and their 5 pups all fed pork (
Suis scrofa) fat. The study included serum IgG measurements (bitches and pups) and specific immune responses towards tetanus toxoid (bitches) and diphtheria toxoid (pups) as well as influenza virus (pups). The analyses showed that IgG concentrations were non-significantly lowest in exposed bitches and pups (t-test: all p
>
0.05). In addition, significant lower antibody response was detected in exposed pups immunized with influenza virus at age 3
months (t-test: both p
<
0.05). No clear group differences were found for tetanus toxoid in bitches and diphtheria toxoid in pups. The results suggest that the humoral immune system of sledge dogs may be suppressed by the dietary blubber composition of OHCs and polyunsaturated fatty acids while a larger follow-up study is recommended in order to investigate this relationship further.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2010.07.076</identifier><identifier>PMID: 20832100</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animal, plant and microbial ecology ; Animals ; Antibody Formation - drug effects ; Applied ecology ; Balaenoptera acutorostrata ; Biological and medical sciences ; Canis familiaris ; Contaminants ; Diet ; Diphtheria ; Dogs ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Environmental Exposure - analysis ; Environmental Pollutants - metabolism ; Environmental Pollutants - toxicity ; Exposure ; Fatty acids ; Female ; Fundamental and applied biological sciences. Psychology ; Greenland ; Humoral immunity ; Hydrocarbons, Halogenated - metabolism ; Hydrocarbons, Halogenated - toxicity ; Immune systems ; Immunity, Humoral - drug effects ; Immunoglobulin G - blood ; Influenza ; Influenza virus ; Male ; Mammalia ; Marine ; Minke whale ; Minke Whale - metabolism ; Organohalogen contaminants ; PCB ; Polar bears ; Sledge dogs ; Trans-generational study ; Ursus maritimus ; West Greenland</subject><ispartof>The Science of the total environment, 2010-11, Vol.408 (23), p.5801-5807</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-a199feebcc959c35ec32c019267da5d887a62837257f7bdb44dc15c8f95a6a3e3</citedby><cites>FETCH-LOGICAL-c465t-a199feebcc959c35ec32c019267da5d887a62837257f7bdb44dc15c8f95a6a3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S004896971000817X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23418794$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20832100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonne, Christian</creatorcontrib><creatorcontrib>Larsen, Hans Jørgen S.</creatorcontrib><creatorcontrib>Kirkegaard, Maja</creatorcontrib><creatorcontrib>Letcher, Robert J.</creatorcontrib><creatorcontrib>Dietz, Rune</creatorcontrib><title>Trans-generational and neonatal humoral immune responses in West Greenland sledge dogs ( Canis familiaris) exposed to organohalogenated environmental contaminants</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Previous investigations in the Arctic have suggested OHC (organohalogen contaminant) induced immune toxic effects on
e.g. polar bears (
Ursus maritimus). We therefore studied the dietary impact from minke whale blubber (
Balaenoptera acutorostrata), rich in polyunsaturated fatty acids and OHCs, on the humoral immunity of 7 captive West Greenland sledge dog (
Canis familiaris) bitches and their 4 pups constituting a sentinel model species for polar bears. A control group was composed of 8 bitches and their 5 pups all fed pork (
Suis scrofa) fat. The study included serum IgG measurements (bitches and pups) and specific immune responses towards tetanus toxoid (bitches) and diphtheria toxoid (pups) as well as influenza virus (pups). The analyses showed that IgG concentrations were non-significantly lowest in exposed bitches and pups (t-test: all p
>
0.05). In addition, significant lower antibody response was detected in exposed pups immunized with influenza virus at age 3
months (t-test: both p
<
0.05). No clear group differences were found for tetanus toxoid in bitches and diphtheria toxoid in pups. The results suggest that the humoral immune system of sledge dogs may be suppressed by the dietary blubber composition of OHCs and polyunsaturated fatty acids while a larger follow-up study is recommended in order to investigate this relationship further.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Applied ecology</subject><subject>Balaenoptera acutorostrata</subject><subject>Biological and medical sciences</subject><subject>Canis familiaris</subject><subject>Contaminants</subject><subject>Diet</subject><subject>Diphtheria</subject><subject>Dogs</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Pollutants - metabolism</subject><subject>Environmental Pollutants - toxicity</subject><subject>Exposure</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Greenland</subject><subject>Humoral immunity</subject><subject>Hydrocarbons, Halogenated - metabolism</subject><subject>Hydrocarbons, Halogenated - toxicity</subject><subject>Immune systems</subject><subject>Immunity, Humoral - drug effects</subject><subject>Immunoglobulin G - blood</subject><subject>Influenza</subject><subject>Influenza virus</subject><subject>Male</subject><subject>Mammalia</subject><subject>Marine</subject><subject>Minke whale</subject><subject>Minke Whale - metabolism</subject><subject>Organohalogen contaminants</subject><subject>PCB</subject><subject>Polar bears</subject><subject>Sledge dogs</subject><subject>Trans-generational study</subject><subject>Ursus maritimus</subject><subject>West Greenland</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhiMEotvCK4AviHLIYsdJ7ByrFS1IlbgUcYxm7cnWq8RePE5VXocnxdEu5QbWSGNb3_j3-HdRvBV8LbhoP-7XZFwKCf3DuuJ5l6sc7bNiJbTqSsGr9nmx4rzWZdd26qw4J9rzPJQWL4uzimtZCc5Xxa-7CJ7KHXqMkFzwMDLwlnnM05QX9_MUYs5ummaPLCIdgick5jz7jpTYTUT041JDI9odMht2xC7ZBrwjNsDkRgfR0QeGj4dAaFkKLMQd-HAPY8jKkPJm7sTF4Cf0i6oJOU3Og0_0qngxwEj4-pQvim_Xn-42n8vbrzdfNle3panbJpUgum5A3BrTNZ2RDRpZGS66qlUWGqu1grbSUlWNGtTWbuvaGtEYPXQNtCBRXhTvj-ceYvgx59b6yZHBMfeGYaZec1V1UrY6k5f_JIVSXNa80m1G1RE1MRBFHPpDdBPEn73g_WJlv--frOwXK3uuciyVb04i83ZC-1T3x7sMvDsBQAbGIRtpHP3lZL38hTpzV0cO8-M9OIyLIHqD1kU0qbfB_fcyvwHQRcW5</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Sonne, Christian</creator><creator>Larsen, Hans Jørgen S.</creator><creator>Kirkegaard, Maja</creator><creator>Letcher, Robert J.</creator><creator>Dietz, Rune</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>7ST</scope><scope>7T5</scope><scope>7TN</scope><scope>7TV</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>20101101</creationdate><title>Trans-generational and neonatal humoral immune responses in West Greenland sledge dogs ( Canis familiaris) exposed to organohalogenated environmental contaminants</title><author>Sonne, Christian ; Larsen, Hans Jørgen S. ; Kirkegaard, Maja ; Letcher, Robert J. ; Dietz, Rune</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-a199feebcc959c35ec32c019267da5d887a62837257f7bdb44dc15c8f95a6a3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Applied ecology</topic><topic>Balaenoptera acutorostrata</topic><topic>Biological and medical sciences</topic><topic>Canis familiaris</topic><topic>Contaminants</topic><topic>Diet</topic><topic>Diphtheria</topic><topic>Dogs</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Pollutants - metabolism</topic><topic>Environmental Pollutants - toxicity</topic><topic>Exposure</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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e.g. polar bears (
Ursus maritimus). We therefore studied the dietary impact from minke whale blubber (
Balaenoptera acutorostrata), rich in polyunsaturated fatty acids and OHCs, on the humoral immunity of 7 captive West Greenland sledge dog (
Canis familiaris) bitches and their 4 pups constituting a sentinel model species for polar bears. A control group was composed of 8 bitches and their 5 pups all fed pork (
Suis scrofa) fat. The study included serum IgG measurements (bitches and pups) and specific immune responses towards tetanus toxoid (bitches) and diphtheria toxoid (pups) as well as influenza virus (pups). The analyses showed that IgG concentrations were non-significantly lowest in exposed bitches and pups (t-test: all p
>
0.05). In addition, significant lower antibody response was detected in exposed pups immunized with influenza virus at age 3
months (t-test: both p
<
0.05). No clear group differences were found for tetanus toxoid in bitches and diphtheria toxoid in pups. The results suggest that the humoral immune system of sledge dogs may be suppressed by the dietary blubber composition of OHCs and polyunsaturated fatty acids while a larger follow-up study is recommended in order to investigate this relationship further.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>20832100</pmid><doi>10.1016/j.scitotenv.2010.07.076</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0048-9697 |
| ispartof | The Science of the total environment, 2010-11, Vol.408 (23), p.5801-5807 |
| issn | 0048-9697 1879-1026 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal, plant and microbial ecology Animals Antibody Formation - drug effects Applied ecology Balaenoptera acutorostrata Biological and medical sciences Canis familiaris Contaminants Diet Diphtheria Dogs Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Environmental Exposure - analysis Environmental Pollutants - metabolism Environmental Pollutants - toxicity Exposure Fatty acids Female Fundamental and applied biological sciences. Psychology Greenland Humoral immunity Hydrocarbons, Halogenated - metabolism Hydrocarbons, Halogenated - toxicity Immune systems Immunity, Humoral - drug effects Immunoglobulin G - blood Influenza Influenza virus Male Mammalia Marine Minke whale Minke Whale - metabolism Organohalogen contaminants PCB Polar bears Sledge dogs Trans-generational study Ursus maritimus West Greenland |
| title | Trans-generational and neonatal humoral immune responses in West Greenland sledge dogs ( Canis familiaris) exposed to organohalogenated environmental contaminants |
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