Simultaneous analysis of the local and systemic immune responses in mice to study the occupational asthma mechanisms induced by chromium and platinum

Abstract As a result of industrial development, increased exposure to platinum and chromium compounds and the subsequent development of occupational asthma (OA) has been reported. Although specific IgE antibodies, an indicator of allergic asthma, against chromium and platinum have been detected in w...

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Veröffentlicht in:	Toxicology (Amsterdam) 2010-11, Vol.277 (1), p.29-37
Hauptverfasser:	Ban, Masarin, Langonné, Isabelle, Goutet, Michèle, Huguet, Nelly, Pépin, Elsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Asthma - chemically induced Asthma - immunology Asthma - pathology Biological and medical sciences Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Chromium - administration & dosage Chromium - toxicity Chronic obstructive pulmonary disease, asthma Disease Models, Animal Emergency Female Interleukin-13 - biosynthesis Interleukin-4 - biosynthesis Intubation, Intratracheal Lymph Nodes - immunology Lymph Nodes - metabolism Lymph Nodes - pathology Medical sciences Metals and various inorganic compounds Mice Mice, Inbred BALB C Occupational asthma Occupational Diseases - chemically induced Occupational Diseases - immunology Occupational Diseases - pathology Platinum - administration & dosage Platinum - toxicity Platinum and chromium exposure Pneumology Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology Th2-dominated Toxicology
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