The origins and evolution of genetic disease risk in modern humans

Patterns and risks of human disease have evolved. In this article, I review evidence regarding the importance of recent adaptive evolution, positive selection, and genomic conflicts in shaping the genetic and phenotypic architectures of polygenic human diseases. Strong recent selection in human popu...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2010-09, Vol.1206 (1), p.80-109
1. Verfasser:	Crespi, Bernard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Evolution Disease Evolution & development Gene Expression Regulation Genetic Predisposition to Disease genetics human evolution Humans polygenic disease Reproduction Risk Factors
Online-Zugang:	Volltext
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