Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2 J cells

Rat pancreatic acinar cells AR 4-2J respond to dexamethasone by differentiation and a decreased proliferation rate. Protein labelling by [^sup 3^H]-mevalonolactone, used as a precursor of farnesyl and geranylgeranyl isoprenoid groups, was increased in the presence of dexamethasone. In these same con...

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Veröffentlicht in:	Molecular and cellular biochemistry 1999-12, Vol.202 (1-2), p.101-108
Hauptverfasser:	Lambert, Monique, Bui, Ngoc Diem
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Enzymes Rodents
Online-Zugang:	Volltext
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