HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays

Because of high intersubtype HIV-1 genetic variability, it has been shown that subtype-specific patterns of resistance to antiretroviral drugs exist. We wished to ascertain whether this might be true for integrase inhibitors. We compared the susceptibility of subtype B and C HIV-1 integrase enzymes,...

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Veröffentlicht in:	AIDS (London) 2010-09, Vol.24 (14), p.2171-2179
Hauptverfasser:	BAR-MAGEN, Tamara, DONAHUE, Daniel A, MCDONOUGH, Emily I, KUHL, Björn D, FALTENBACHER, Verena H, HONGTAO XU, MICHAUD, Veronique, SLOAN, Richard D, WAINBERG, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cells, Cultured DNA, Viral - drug effects DNA, Viral - genetics Drug Resistance, Viral - drug effects Drug Resistance, Viral - genetics Genetic Variation HIV Infections - drug therapy HIV Infections - genetics HIV Integrase - genetics HIV Integrase Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Mutation Pharmacology. Drug treatments Pyrrolidinones - pharmacology Raltegravir Potassium Sequence Analysis, DNA Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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