Population pharmacokinetics of plasma-derived C1 esterase inhibitor concentrate used to treat acute hereditary angioedema attacks

Background C1 esterase inhibitor (C1-INH) replacement is recommended as a first-line therapy for acute edema attacks in hereditary angioedema (HAE). Only limited pharmacokinetic analyses of the administered C1-INH in plasma are available. Objective To investigate retrospectively the population pharm...

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Veröffentlicht in:	Annals of allergy, asthma, & immunology asthma, & immunology, 2010-08, Vol.105 (2), p.149-154
Hauptverfasser:	Bernstein, Jonathan A., MD, Ritchie, Bruce, MD, Levy, Robyn J., MD, Wasserman, Richard L., MD, PhD, Bewtra, Againdra K., MD, Hurewitz, David S., MD, Obtulowicz, Krystyna, MD, Reshef, Avner, MD, Moldovan, Dumitru, MD, Shirov, Todor, MD, Grivcheva-Panovska, Vesna, MD, Kiessling, Peter C., PhD, Schindel, Fritz, MS, Craig, Timothy J., DO
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Aged Aged, 80 and over Allergic diseases Allergy and Immunology Biological and medical sciences Child Complement C1 Inhibitor Protein - administration & dosage Complement C1 Inhibitor Protein - genetics Complement C1 Inhibitor Protein - pharmacokinetics Dermatology Fundamental and applied biological sciences. Psychology Fundamental immunology Half-Life Hereditary Angioedema Types I and II - blood Hereditary Angioedema Types I and II - diagnosis Hereditary Angioedema Types I and II - drug therapy Humans Immunopathology Medical sciences Middle Aged Models, Biological Population Groups Retrospective Studies Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin allergic diseases. Stinging insect allergies
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