Molecular Basis of Pathogenicity in Helicobacter pylori Clinical Isolates

This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes w...

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Veröffentlicht in:	Journal of Clinical Microbiology 2010-10, Vol.48 (10), p.3776-3778
Hauptverfasser:	Ramis, Ivy Bastos, Fonseca, Tesiê Leopoldo, Moraes, Ernani Pinho de, Fernandes, Márcia Silveira, Mendoza-Sassi, Raul, Rodrigues, Obirajara, Juliano, Carlos Renan Varela, Scaini, Carlos James, Almeida da Silva, Pedro Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - genetics Bacterial Outer Membrane Proteins - genetics Bacterial Proteins - genetics Bacteriology Biological and medical sciences DNA, Bacterial - genetics Fundamental and applied biological sciences. Psychology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - isolation & purification Helicobacter pylori - pathogenicity Humans Microbiology Miscellaneous Polymerase Chain Reaction Virulence Factors - genetics
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Zusammenfassung:	This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00472-10