Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City

Objectives Reports of Enterobacteriaceae resistant to all commonly used antimicrobial agents, including β-lactams, fluoroquinolones and aminoglycosides, are increasing in hospitals worldwide. The activity of ACHN-490, a next-generation aminoglycoside, was examined against clinical isolates of Escher...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-10, Vol.65 (10), p.2123-2127
Hauptverfasser:	Landman, David, Babu, Elizabeth, Shah, Neha, Kelly, Paul, Bäcker, Martin, Bratu, Simona, Quale, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides - pharmacology Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents antimicrobial resistance surveillance Bacterial Proteins - genetics Bacteriology beta-Lactamases - genetics Biological and medical sciences DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug resistance E coli Enterobacteriaceae Escherichia coli Escherichia coli - drug effects Escherichia coli - isolation & purification Escherichia coli Infections - microbiology Gram-negative bacteria Hospitals Humans Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - isolation & purification mechanisms of resistance Medical sciences Microbial Sensitivity Tests Molecular Sequence Data multidrug resistant New York City Pharmacology. Drug treatments Polymerase Chain Reaction Sequence Analysis, DNA Sisomicin - analogs & derivatives Sisomicin - pharmacology tRNA Methyltransferases - genetics
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