Validation of an LC-MS Method for the Detection and Quantification of BZP and TFMPP and their Hydroxylated Metabolites in Human Plasma and its Application to the Pharmacokinetic Study of TFMPP in Humans

: An LC–MS method was developed for benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP), constituents of “party pills” or “legal herbal highs,” and their metabolites in human blood plasma. Compounds were resolved using a mixture of ammonium formate (pH 4.5, 0.01 M) and acetonitrile (...

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Veröffentlicht in:	Journal of forensic sciences 2010-09, Vol.55 (5), p.1311-1318
Hauptverfasser:	Antia, Ushtana, Tingle, Malcolm D., Russell, Bruce R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Acidity Adolescent Adult Blood BZP Chromatography, Liquid Female forensic science Forensic sciences Forensic Toxicology Humans liquid chromatography-mass spectrometry Male Mass Spectrometry metabolism Metabolites pharmacokinetics Pharmacology Piperazines - blood Piperazines - pharmacokinetics Piperazines - urine Plasma Psychotropic drugs Specimen Handling Street Drugs - blood Street Drugs - pharmacokinetics Street Drugs - urine TFMPP toxicology Young Adult
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