Premenstrual asthma and atopy markers
Background The frequency of atopy in women with premenstrual asthma (PMA) and its possible effect on the premenstrual exacerbation of asthma are unknown. Objective To analyze the relation between atopy markers (total IgE, Phadiatop, and specific IgE) and PMA. Methods Asthmatic women of reproductive...
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| Veröffentlicht in: | Annals of allergy, asthma, & immunology asthma, & immunology, 2010-09, Vol.105 (3), p.218-222 |
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| creator | Pereira-Vega, Antonio, MD, PhD Sánchez, José L., MD, PhD Maldonado, José A., MD Borrero, Fátima, MD Rico, Ignacio Vázquez, MD Vázquez, Rosa, MD, PhD Álvarez, Francisco, MD, PhD Ignacio, José M., MD, PhD Romero, Pedro, MD, PhD Gil, Francisco L., MD |
| description | Background The frequency of atopy in women with premenstrual asthma (PMA) and its possible effect on the premenstrual exacerbation of asthma are unknown. Objective To analyze the relation between atopy markers (total IgE, Phadiatop, and specific IgE) and PMA. Methods Asthmatic women of reproductive age completed a questionnaire about respiratory symptoms and recorded peak flow during an entire menstrual cycle to be classified as asthmatic patients with or without PMA. Their asthma severity was graded according to the 2005 Global Initiative for Asthma scale. PMA was defined as a clinical or functional exacerbation (≥20%) in the premenstrual phase compared with the preovulatory phase. Blood tests for several atopy markers were conducted for: total IgE and screening for aeroallergens (Phadiatop) and specific IgE. Results Blood determinations were performed in 59 asthmatic women, of whom 31 (53%) had PMA. Twenty-six patients with PMA (84%) and 12 without PMA (43%) had total IgE values greater than 100 kU/L ( P = .001). Twenty-one patients with PMA (68%) and 14 without PMA (50%) tested positive for Phadiatop ( P = .17). Those who were positive for Phadiatop were also tested for specific IgE. No relation was found between specific IgE and PMA; values for ryegrass (63%), olive (60%), and Dermatophagoides pteronyssinus (54%) exceeded 0.35 kU/L. Conclusions PMA seems to be closely linked to total IgE levels but not to specific allergens. The atopy affects the clinical manifestations of PMA in women of reproductive age. |
| doi_str_mv | 10.1016/j.anai.2010.06.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_807279261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1081120610006587</els_id><sourcerecordid>807279261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-fd4da77b53968b9e7f30ff6cc63a522ec60d64b7415a946a84d541e3c6a5e2033</originalsourceid><addsrcrecordid>eNqFkUuLFDEURoMozkP_gAvpzeCq2pt3CkQYBkeFAQdG1-F26hampx5tUiX0v5-U3Sq4GFcJ4Xw3yfkYe8VhzYGbt9s1DhjXAsoBmDUI8YSdci1VpZQ0T8seHK-4AHPCznLeAgB3Rj5nJwIcgHXulF3cJuppyFOasVthnr73uMKhWeE07varHtM9pfyCPWuxy_TyuJ6zb9cfvl59qm6-fPx8dXlTBWXFVLWNatDajZa1cZuabCuhbU0IRqIWgoKBxqiNVVxjrQw61WjFSQaDmgRIec7eHObu0vhjpjz5PuZAXYcDjXP2DqywtTD8v6TVCoSxShdSHMiQxpwTtX6XYvnX3nPwi0e_9YtHv3j0YHzxWEKvj-PnTU_Nn8hvcQW4OAKYA3ZtwiHE_JeTQtbiF_fuwFHR9jNS8jlEGgI1MVGYfDPGx9_x_p946OIQy433tKe8Hec0lEI891l48HdL40vhvHRttLPyAVcoo0M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754026745</pqid></control><display><type>article</type><title>Premenstrual asthma and atopy markers</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pereira-Vega, Antonio, MD, PhD ; Sánchez, José L., MD, PhD ; Maldonado, José A., MD ; Borrero, Fátima, MD ; Rico, Ignacio Vázquez, MD ; Vázquez, Rosa, MD, PhD ; Álvarez, Francisco, MD, PhD ; Ignacio, José M., MD, PhD ; Romero, Pedro, MD, PhD ; Gil, Francisco L., MD</creator><creatorcontrib>Pereira-Vega, Antonio, MD, PhD ; Sánchez, José L., MD, PhD ; Maldonado, José A., MD ; Borrero, Fátima, MD ; Rico, Ignacio Vázquez, MD ; Vázquez, Rosa, MD, PhD ; Álvarez, Francisco, MD, PhD ; Ignacio, José M., MD, PhD ; Romero, Pedro, MD, PhD ; Gil, Francisco L., MD</creatorcontrib><description>Background The frequency of atopy in women with premenstrual asthma (PMA) and its possible effect on the premenstrual exacerbation of asthma are unknown. Objective To analyze the relation between atopy markers (total IgE, Phadiatop, and specific IgE) and PMA. Methods Asthmatic women of reproductive age completed a questionnaire about respiratory symptoms and recorded peak flow during an entire menstrual cycle to be classified as asthmatic patients with or without PMA. Their asthma severity was graded according to the 2005 Global Initiative for Asthma scale. PMA was defined as a clinical or functional exacerbation (≥20%) in the premenstrual phase compared with the preovulatory phase. Blood tests for several atopy markers were conducted for: total IgE and screening for aeroallergens (Phadiatop) and specific IgE. Results Blood determinations were performed in 59 asthmatic women, of whom 31 (53%) had PMA. Twenty-six patients with PMA (84%) and 12 without PMA (43%) had total IgE values greater than 100 kU/L ( P = .001). Twenty-one patients with PMA (68%) and 14 without PMA (50%) tested positive for Phadiatop ( P = .17). Those who were positive for Phadiatop were also tested for specific IgE. No relation was found between specific IgE and PMA; values for ryegrass (63%), olive (60%), and Dermatophagoides pteronyssinus (54%) exceeded 0.35 kU/L. Conclusions PMA seems to be closely linked to total IgE levels but not to specific allergens. The atopy affects the clinical manifestations of PMA in women of reproductive age.</description><identifier>ISSN: 1081-1206</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/j.anai.2010.06.022</identifier><identifier>PMID: 20800788</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Allergens - immunology ; Allergy and Immunology ; Asthma - blood ; Asthma - complications ; Asthma - epidemiology ; Asthma - physiopathology ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Dermatology ; Dermatophagoides pteronyssinus ; Disease Progression ; Epitopes ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunoglobulin E - blood ; Medical sciences ; Menstrual Cycle - blood ; Olea ; Pneumology ; Premenstrual Syndrome - blood ; Premenstrual Syndrome - epidemiology ; Premenstrual Syndrome - etiology ; Premenstrual Syndrome - physiopathology ; Respiration Disorders ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>Annals of allergy, asthma, & immunology, 2010-09, Vol.105 (3), p.218-222</ispartof><rights>American College of Allergy, Asthma & Immunology</rights><rights>2010 American College of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-fd4da77b53968b9e7f30ff6cc63a522ec60d64b7415a946a84d541e3c6a5e2033</citedby><cites>FETCH-LOGICAL-c472t-fd4da77b53968b9e7f30ff6cc63a522ec60d64b7415a946a84d541e3c6a5e2033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1081120610006587$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23239288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20800788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira-Vega, Antonio, MD, PhD</creatorcontrib><creatorcontrib>Sánchez, José L., MD, PhD</creatorcontrib><creatorcontrib>Maldonado, José A., MD</creatorcontrib><creatorcontrib>Borrero, Fátima, MD</creatorcontrib><creatorcontrib>Rico, Ignacio Vázquez, MD</creatorcontrib><creatorcontrib>Vázquez, Rosa, MD, PhD</creatorcontrib><creatorcontrib>Álvarez, Francisco, MD, PhD</creatorcontrib><creatorcontrib>Ignacio, José M., MD, PhD</creatorcontrib><creatorcontrib>Romero, Pedro, MD, PhD</creatorcontrib><creatorcontrib>Gil, Francisco L., MD</creatorcontrib><title>Premenstrual asthma and atopy markers</title><title>Annals of allergy, asthma, & immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Background The frequency of atopy in women with premenstrual asthma (PMA) and its possible effect on the premenstrual exacerbation of asthma are unknown. Objective To analyze the relation between atopy markers (total IgE, Phadiatop, and specific IgE) and PMA. Methods Asthmatic women of reproductive age completed a questionnaire about respiratory symptoms and recorded peak flow during an entire menstrual cycle to be classified as asthmatic patients with or without PMA. Their asthma severity was graded according to the 2005 Global Initiative for Asthma scale. PMA was defined as a clinical or functional exacerbation (≥20%) in the premenstrual phase compared with the preovulatory phase. Blood tests for several atopy markers were conducted for: total IgE and screening for aeroallergens (Phadiatop) and specific IgE. Results Blood determinations were performed in 59 asthmatic women, of whom 31 (53%) had PMA. Twenty-six patients with PMA (84%) and 12 without PMA (43%) had total IgE values greater than 100 kU/L ( P = .001). Twenty-one patients with PMA (68%) and 14 without PMA (50%) tested positive for Phadiatop ( P = .17). Those who were positive for Phadiatop were also tested for specific IgE. No relation was found between specific IgE and PMA; values for ryegrass (63%), olive (60%), and Dermatophagoides pteronyssinus (54%) exceeded 0.35 kU/L. Conclusions PMA seems to be closely linked to total IgE levels but not to specific allergens. The atopy affects the clinical manifestations of PMA in women of reproductive age.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergens - immunology</subject><subject>Allergy and Immunology</subject><subject>Asthma - blood</subject><subject>Asthma - complications</subject><subject>Asthma - epidemiology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Dermatology</subject><subject>Dermatophagoides pteronyssinus</subject><subject>Disease Progression</subject><subject>Epitopes</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Medical sciences</subject><subject>Menstrual Cycle - blood</subject><subject>Olea</subject><subject>Pneumology</subject><subject>Premenstrual Syndrome - blood</subject><subject>Premenstrual Syndrome - epidemiology</subject><subject>Premenstrual Syndrome - etiology</subject><subject>Premenstrual Syndrome - physiopathology</subject><subject>Respiration Disorders</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><issn>1081-1206</issn><issn>1534-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEURoMozkP_gAvpzeCq2pt3CkQYBkeFAQdG1-F26hampx5tUiX0v5-U3Sq4GFcJ4Xw3yfkYe8VhzYGbt9s1DhjXAsoBmDUI8YSdci1VpZQ0T8seHK-4AHPCznLeAgB3Rj5nJwIcgHXulF3cJuppyFOasVthnr73uMKhWeE07varHtM9pfyCPWuxy_TyuJ6zb9cfvl59qm6-fPx8dXlTBWXFVLWNatDajZa1cZuabCuhbU0IRqIWgoKBxqiNVVxjrQw61WjFSQaDmgRIec7eHObu0vhjpjz5PuZAXYcDjXP2DqywtTD8v6TVCoSxShdSHMiQxpwTtX6XYvnX3nPwi0e_9YtHv3j0YHzxWEKvj-PnTU_Nn8hvcQW4OAKYA3ZtwiHE_JeTQtbiF_fuwFHR9jNS8jlEGgI1MVGYfDPGx9_x_p946OIQy433tKe8Hec0lEI891l48HdL40vhvHRttLPyAVcoo0M</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Pereira-Vega, Antonio, MD, PhD</creator><creator>Sánchez, José L., MD, PhD</creator><creator>Maldonado, José A., MD</creator><creator>Borrero, Fátima, MD</creator><creator>Rico, Ignacio Vázquez, MD</creator><creator>Vázquez, Rosa, MD, PhD</creator><creator>Álvarez, Francisco, MD, PhD</creator><creator>Ignacio, José M., MD, PhD</creator><creator>Romero, Pedro, MD, PhD</creator><creator>Gil, Francisco L., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100901</creationdate><title>Premenstrual asthma and atopy markers</title><author>Pereira-Vega, Antonio, MD, PhD ; Sánchez, José L., MD, PhD ; Maldonado, José A., MD ; Borrero, Fátima, MD ; Rico, Ignacio Vázquez, MD ; Vázquez, Rosa, MD, PhD ; Álvarez, Francisco, MD, PhD ; Ignacio, José M., MD, PhD ; Romero, Pedro, MD, PhD ; Gil, Francisco L., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-fd4da77b53968b9e7f30ff6cc63a522ec60d64b7415a946a84d541e3c6a5e2033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergens - immunology</topic><topic>Allergy and Immunology</topic><topic>Asthma - blood</topic><topic>Asthma - complications</topic><topic>Asthma - epidemiology</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Dermatology</topic><topic>Dermatophagoides pteronyssinus</topic><topic>Disease Progression</topic><topic>Epitopes</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Medical sciences</topic><topic>Menstrual Cycle - blood</topic><topic>Olea</topic><topic>Pneumology</topic><topic>Premenstrual Syndrome - blood</topic><topic>Premenstrual Syndrome - epidemiology</topic><topic>Premenstrual Syndrome - etiology</topic><topic>Premenstrual Syndrome - physiopathology</topic><topic>Respiration Disorders</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira-Vega, Antonio, MD, PhD</creatorcontrib><creatorcontrib>Sánchez, José L., MD, PhD</creatorcontrib><creatorcontrib>Maldonado, José A., MD</creatorcontrib><creatorcontrib>Borrero, Fátima, MD</creatorcontrib><creatorcontrib>Rico, Ignacio Vázquez, MD</creatorcontrib><creatorcontrib>Vázquez, Rosa, MD, PhD</creatorcontrib><creatorcontrib>Álvarez, Francisco, MD, PhD</creatorcontrib><creatorcontrib>Ignacio, José M., MD, PhD</creatorcontrib><creatorcontrib>Romero, Pedro, MD, PhD</creatorcontrib><creatorcontrib>Gil, Francisco L., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of allergy, asthma, & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira-Vega, Antonio, MD, PhD</au><au>Sánchez, José L., MD, PhD</au><au>Maldonado, José A., MD</au><au>Borrero, Fátima, MD</au><au>Rico, Ignacio Vázquez, MD</au><au>Vázquez, Rosa, MD, PhD</au><au>Álvarez, Francisco, MD, PhD</au><au>Ignacio, José M., MD, PhD</au><au>Romero, Pedro, MD, PhD</au><au>Gil, Francisco L., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premenstrual asthma and atopy markers</atitle><jtitle>Annals of allergy, asthma, & immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>105</volume><issue>3</issue><spage>218</spage><epage>222</epage><pages>218-222</pages><issn>1081-1206</issn><eissn>1534-4436</eissn><abstract>Background The frequency of atopy in women with premenstrual asthma (PMA) and its possible effect on the premenstrual exacerbation of asthma are unknown. Objective To analyze the relation between atopy markers (total IgE, Phadiatop, and specific IgE) and PMA. Methods Asthmatic women of reproductive age completed a questionnaire about respiratory symptoms and recorded peak flow during an entire menstrual cycle to be classified as asthmatic patients with or without PMA. Their asthma severity was graded according to the 2005 Global Initiative for Asthma scale. PMA was defined as a clinical or functional exacerbation (≥20%) in the premenstrual phase compared with the preovulatory phase. Blood tests for several atopy markers were conducted for: total IgE and screening for aeroallergens (Phadiatop) and specific IgE. Results Blood determinations were performed in 59 asthmatic women, of whom 31 (53%) had PMA. Twenty-six patients with PMA (84%) and 12 without PMA (43%) had total IgE values greater than 100 kU/L ( P = .001). Twenty-one patients with PMA (68%) and 14 without PMA (50%) tested positive for Phadiatop ( P = .17). Those who were positive for Phadiatop were also tested for specific IgE. No relation was found between specific IgE and PMA; values for ryegrass (63%), olive (60%), and Dermatophagoides pteronyssinus (54%) exceeded 0.35 kU/L. Conclusions PMA seems to be closely linked to total IgE levels but not to specific allergens. The atopy affects the clinical manifestations of PMA in women of reproductive age.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20800788</pmid><doi>10.1016/j.anai.2010.06.022</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Allergens - immunology Allergy and Immunology Asthma - blood Asthma - complications Asthma - epidemiology Asthma - physiopathology Biological and medical sciences Chronic obstructive pulmonary disease, asthma Dermatology Dermatophagoides pteronyssinus Disease Progression Epitopes Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoglobulin E - blood Medical sciences Menstrual Cycle - blood Olea Pneumology Premenstrual Syndrome - blood Premenstrual Syndrome - epidemiology Premenstrual Syndrome - etiology Premenstrual Syndrome - physiopathology Respiration Disorders Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Premenstrual asthma and atopy markers |
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