Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease
Both bacterial virulence factors and the pattern of Helicobacter pylori (H. pylori) gastritis may contribute to the development of clinically relevant gastroduodenal disease. The aim of our study was to investigate the frequency of H. pylori vacA alleles, iceA, and cagA, and the pattern of gastritis...
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| Veröffentlicht in: | The American journal of gastroenterology 2001-04, Vol.96 (4), p.1008-1013 |
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| creator | MIEHLKE, Stephan JUN YU SCHUPPLER, Markus FRINGS, Christian KIRSCH, Christian NEGRASZUS, Nico MORGNER, Andrea STOLTE, Manfred EHNINGER, Gerhard BAYERDORFFER, Ekkehard |
| description | Both bacterial virulence factors and the pattern of Helicobacter pylori (H. pylori) gastritis may contribute to the development of clinically relevant gastroduodenal disease. The aim of our study was to investigate the frequency of H. pylori vacA alleles, iceA, and cagA, and the pattern of gastritis in patients with gastric cancer (GC), gastric lymphoma (MALT), duodenal ulcer (DU), and functional dyspepsia (FD).
H. pylori was cultured from 141 patients (34 GC, 26 MALT, 49 DU, 32 FD). Allelic variants of vacA and iceA, and cagA were identified by polymerase chain reaction. Antrum and corpus biopsies were obtained for assessment of gastritis according to the updated Sydney System.
The vacA sl,ml genotype was more frequently detected in H. pylori from GC patients (70.6%) than from MALT, DU, and FD patients (p < 0.05). The frequency of iceA1 and cagA did not differ among the groups. The proportion of patients with severe gastritis in the corpus was significantly higher in patients with GC and MALT compared with patients with DU (p < 0.001).
In a German patient population, only the vacA s1,m1 genotype of H. pylori is associated with GC, and therefore may be useful to identify infected patients being at an increased risk for GC. |
| doi_str_mv | 10.1111/j.1572-0241.2001.03685.x |
| format | Article |
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H. pylori was cultured from 141 patients (34 GC, 26 MALT, 49 DU, 32 FD). Allelic variants of vacA and iceA, and cagA were identified by polymerase chain reaction. Antrum and corpus biopsies were obtained for assessment of gastritis according to the updated Sydney System.
The vacA sl,ml genotype was more frequently detected in H. pylori from GC patients (70.6%) than from MALT, DU, and FD patients (p < 0.05). The frequency of iceA1 and cagA did not differ among the groups. The proportion of patients with severe gastritis in the corpus was significantly higher in patients with GC and MALT compared with patients with DU (p < 0.001).
In a German patient population, only the vacA s1,m1 genotype of H. pylori is associated with GC, and therefore may be useful to identify infected patients being at an increased risk for GC.</description><identifier>ISSN: 0002-9270</identifier><identifier>EISSN: 1572-0241</identifier><identifier>DOI: 10.1111/j.1572-0241.2001.03685.x</identifier><identifier>PMID: 11316139</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing</publisher><subject>Aged ; Antigens, Bacterial ; Bacterial Outer Membrane Proteins - analysis ; Bacterial Proteins - analysis ; Benign ; Biological and medical sciences ; Duodenal Ulcer - microbiology ; Dyspepsia - microbiology ; Female ; Gastritis - microbiology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Helicobacter Infections - complications ; Helicobacter pylori ; Helicobacter pylori - genetics ; Humans ; Lymphoma, B-Cell, Marginal Zone - microbiology ; Male ; Medical sciences ; Stomach Neoplasms - microbiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>The American journal of gastroenterology, 2001-04, Vol.96 (4), p.1008-1013</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-31487cb0b8721f63328751c16bba036fba312bd69a6d3c079b0e4be1a5034c083</citedby><cites>FETCH-LOGICAL-c331t-31487cb0b8721f63328751c16bba036fba312bd69a6d3c079b0e4be1a5034c083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=951013$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11316139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIEHLKE, Stephan</creatorcontrib><creatorcontrib>JUN YU</creatorcontrib><creatorcontrib>SCHUPPLER, Markus</creatorcontrib><creatorcontrib>FRINGS, Christian</creatorcontrib><creatorcontrib>KIRSCH, Christian</creatorcontrib><creatorcontrib>NEGRASZUS, Nico</creatorcontrib><creatorcontrib>MORGNER, Andrea</creatorcontrib><creatorcontrib>STOLTE, Manfred</creatorcontrib><creatorcontrib>EHNINGER, Gerhard</creatorcontrib><creatorcontrib>BAYERDORFFER, Ekkehard</creatorcontrib><title>Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease</title><title>The American journal of gastroenterology</title><addtitle>Am J Gastroenterol</addtitle><description>Both bacterial virulence factors and the pattern of Helicobacter pylori (H. pylori) gastritis may contribute to the development of clinically relevant gastroduodenal disease. The aim of our study was to investigate the frequency of H. pylori vacA alleles, iceA, and cagA, and the pattern of gastritis in patients with gastric cancer (GC), gastric lymphoma (MALT), duodenal ulcer (DU), and functional dyspepsia (FD).
H. pylori was cultured from 141 patients (34 GC, 26 MALT, 49 DU, 32 FD). Allelic variants of vacA and iceA, and cagA were identified by polymerase chain reaction. Antrum and corpus biopsies were obtained for assessment of gastritis according to the updated Sydney System.
The vacA sl,ml genotype was more frequently detected in H. pylori from GC patients (70.6%) than from MALT, DU, and FD patients (p < 0.05). The frequency of iceA1 and cagA did not differ among the groups. The proportion of patients with severe gastritis in the corpus was significantly higher in patients with GC and MALT compared with patients with DU (p < 0.001).
In a German patient population, only the vacA s1,m1 genotype of H. pylori is associated with GC, and therefore may be useful to identify infected patients being at an increased risk for GC.</description><subject>Aged</subject><subject>Antigens, Bacterial</subject><subject>Bacterial Outer Membrane Proteins - analysis</subject><subject>Bacterial Proteins - analysis</subject><subject>Benign</subject><subject>Biological and medical sciences</subject><subject>Duodenal Ulcer - microbiology</subject><subject>Dyspepsia - microbiology</subject><subject>Female</subject><subject>Gastritis - microbiology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - genetics</subject><subject>Humans</subject><subject>Lymphoma, B-Cell, Marginal Zone - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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The aim of our study was to investigate the frequency of H. pylori vacA alleles, iceA, and cagA, and the pattern of gastritis in patients with gastric cancer (GC), gastric lymphoma (MALT), duodenal ulcer (DU), and functional dyspepsia (FD).
H. pylori was cultured from 141 patients (34 GC, 26 MALT, 49 DU, 32 FD). Allelic variants of vacA and iceA, and cagA were identified by polymerase chain reaction. Antrum and corpus biopsies were obtained for assessment of gastritis according to the updated Sydney System.
The vacA sl,ml genotype was more frequently detected in H. pylori from GC patients (70.6%) than from MALT, DU, and FD patients (p < 0.05). The frequency of iceA1 and cagA did not differ among the groups. The proportion of patients with severe gastritis in the corpus was significantly higher in patients with GC and MALT compared with patients with DU (p < 0.001).
In a German patient population, only the vacA s1,m1 genotype of H. pylori is associated with GC, and therefore may be useful to identify infected patients being at an increased risk for GC.</abstract><cop>Oxford</cop><pub>Blackwell Publishing</pub><pmid>11316139</pmid><doi>10.1111/j.1572-0241.2001.03685.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Antigens, Bacterial Bacterial Outer Membrane Proteins - analysis Bacterial Proteins - analysis Benign Biological and medical sciences Duodenal Ulcer - microbiology Dyspepsia - microbiology Female Gastritis - microbiology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Genotype Helicobacter Infections - complications Helicobacter pylori Helicobacter pylori - genetics Humans Lymphoma, B-Cell, Marginal Zone - microbiology Male Medical sciences Stomach Neoplasms - microbiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease |
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