Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa

Expression of the MexEF-OprN efflux pump in Pseudomonas aeruginosa seems to be upregulated by MexT. The region upstream of the mexEF-oprN operon contains mexT arranged in tandem with mexEF-oprN and separated by 230 bp of mexT-mexE intergenic DNA. Therefore, it is likely that this intergenic DNA cont...

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Veröffentlicht in:	FEMS microbiology letters 2010-10, Vol.311 (1), p.36-43
Hauptverfasser:	Maseda, Hideaki, Uwate, Maki, Nakae, Taiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Binding sites Deoxyribonucleic acid DNA DNA-directed RNA polymerase Efflux efflux pump Gene deletion Gene Expression Regulation, Bacterial Gene regulation Inverted repeat mexEF-oprN mexT Microbiology Mutation nod box Operon Protein Binding Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA polymerase Transcription Transcription, Genetic
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