p53 mRNA controls p53 activity by managing Mdm2 functions

The E3 ubiquitin ligase Mdm2 is a focal regulator of p53 tumour suppressor activity. It binds p53, promoting its polyubiquitination and degradation, and also controls p53 synthesis. However, it is not known how this dual function of Mdm2 on p53 synthesis and degradation is achieved. Here we show tha...

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Veröffentlicht in:	Nature cell biology 2008-09, Vol.10 (9), p.1098-1105
Hauptverfasser:	Bourougaa, Karima, Malbert-Colas, Laurence, Maslon, Magda M, Powell, Darren J, Fåhraeus, Robin, Candeias, Marco M, Daskalogianni, Chrysoula, Naski, Nadia, Calvo, Fabien
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Base Sequence Biomedical and Life Sciences Cancer Research Cell Biology Control Degradation Developmental Biology Gene Expression Regulation Health aspects Humans letter Life Sciences Messenger RNA Models, Biological Mutation Protein Binding Protein Biosynthesis Protein Structure, Tertiary Protein synthesis Proteins Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Stem Cells Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ubiquitin-Protein Ligases - metabolism
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