Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
Helicobacter pylori , one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging...
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| Veröffentlicht in: | Nature (London) 1999-01, Vol.397 (6715), p.176-180 |
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| creator | Alm, Richard A. Ling, Lo-See L. Moir, Donald T. King, Benjamin L. Brown, Eric D. Doig, Peter C. Smith, Douglas R. Noonan, Brian Guild, Braydon C. deJonge, Boudewijn L. Carmel, Gilles Tummino, Peter J. Caruso, Anthony Uria-Nickelsen, Maria Mills, Debra M. Ives, Cameron Gibson, Rene Merberg, David Mills, Scott D. Jiang, Qin Taylor, Diane E. Vovis, Gerald F. Trust, Trevor J. |
| description | Helicobacter pylori
, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma
1
. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host
2
,
3
and to participate in the lifelong chronicity of infection
4
. Here we compare the complete genomic sequences of two unrelated
H. pylori
isolates. This is, to our knowledge, the first such genomic comparison.
H. pylori
was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region. |
| doi_str_mv | 10.1038/16495 |
| format | Article |
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, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma
1
. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host
2
,
3
and to participate in the lifelong chronicity of infection
4
. Here we compare the complete genomic sequences of two unrelated
H. pylori
isolates. This is, to our knowledge, the first such genomic comparison.
H. pylori
was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/16495</identifier><identifier>PMID: 9923682</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Bacteria ; Bacteriology ; Biological and medical sciences ; Digestive system ; Disease ; Duodenal Ulcer - microbiology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial ; Genetic diversity ; Genetics ; Genome, Bacterial ; Genomics ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - classification ; Helicobacter pylori - genetics ; Humanities and Social Sciences ; Humans ; letter ; Lymphoma ; Microbiology ; Molecular Sequence Data ; multidisciplinary ; Pathogens ; Science ; Science (multidisciplinary) ; Sequence Alignment ; Sequence Analysis, DNA ; Species Specificity</subject><ispartof>Nature (London), 1999-01, Vol.397 (6715), p.176-180</ispartof><rights>Macmillan Magazines Ltd. 1999</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Jan 14, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-a7452449df22c560af478a11db70c3c1e04224c71272d9152aafd9f3f07788ef3</citedby><cites>FETCH-LOGICAL-c520t-a7452449df22c560af478a11db70c3c1e04224c71272d9152aafd9f3f07788ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/16495$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/16495$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1684025$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9923682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alm, Richard A.</creatorcontrib><creatorcontrib>Ling, Lo-See L.</creatorcontrib><creatorcontrib>Moir, Donald T.</creatorcontrib><creatorcontrib>King, Benjamin L.</creatorcontrib><creatorcontrib>Brown, Eric D.</creatorcontrib><creatorcontrib>Doig, Peter C.</creatorcontrib><creatorcontrib>Smith, Douglas R.</creatorcontrib><creatorcontrib>Noonan, Brian</creatorcontrib><creatorcontrib>Guild, Braydon C.</creatorcontrib><creatorcontrib>deJonge, Boudewijn L.</creatorcontrib><creatorcontrib>Carmel, Gilles</creatorcontrib><creatorcontrib>Tummino, Peter J.</creatorcontrib><creatorcontrib>Caruso, Anthony</creatorcontrib><creatorcontrib>Uria-Nickelsen, Maria</creatorcontrib><creatorcontrib>Mills, Debra M.</creatorcontrib><creatorcontrib>Ives, Cameron</creatorcontrib><creatorcontrib>Gibson, Rene</creatorcontrib><creatorcontrib>Merberg, David</creatorcontrib><creatorcontrib>Mills, Scott D.</creatorcontrib><creatorcontrib>Jiang, Qin</creatorcontrib><creatorcontrib>Taylor, Diane E.</creatorcontrib><creatorcontrib>Vovis, Gerald F.</creatorcontrib><creatorcontrib>Trust, Trevor J.</creatorcontrib><title>Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Helicobacter pylori
, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma
1
. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host
2
,
3
and to participate in the lifelong chronicity of infection
4
. Here we compare the complete genomic sequences of two unrelated
H. pylori
isolates. This is, to our knowledge, the first such genomic comparison.
H. pylori
was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region.</description><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Disease</subject><subject>Duodenal Ulcer - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Genetic diversity</subject><subject>Genetics</subject><subject>Genome, Bacterial</subject><subject>Genomics</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - classification</subject><subject>Helicobacter pylori - genetics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Lymphoma</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Pathogens</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Species 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comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori</title><author>Alm, Richard A. ; Ling, Lo-See L. ; Moir, Donald T. ; King, Benjamin L. ; Brown, Eric D. ; Doig, Peter C. ; Smith, Douglas R. ; Noonan, Brian ; Guild, Braydon C. ; deJonge, Boudewijn L. ; Carmel, Gilles ; Tummino, Peter J. ; Caruso, Anthony ; Uria-Nickelsen, Maria ; Mills, Debra M. ; Ives, Cameron ; Gibson, Rene ; Merberg, David ; Mills, Scott D. ; Jiang, Qin ; Taylor, Diane E. ; Vovis, Gerald F. ; Trust, Trevor J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-a7452449df22c560af478a11db70c3c1e04224c71272d9152aafd9f3f07788ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Disease</topic><topic>Duodenal Ulcer - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Genetic diversity</topic><topic>Genetics</topic><topic>Genome, Bacterial</topic><topic>Genomics</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - classification</topic><topic>Helicobacter pylori - genetics</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Lymphoma</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Pathogens</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alm, Richard A.</creatorcontrib><creatorcontrib>Ling, Lo-See L.</creatorcontrib><creatorcontrib>Moir, Donald T.</creatorcontrib><creatorcontrib>King, 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L.</au><au>Moir, Donald T.</au><au>King, Benjamin L.</au><au>Brown, Eric D.</au><au>Doig, Peter C.</au><au>Smith, Douglas R.</au><au>Noonan, Brian</au><au>Guild, Braydon C.</au><au>deJonge, Boudewijn L.</au><au>Carmel, Gilles</au><au>Tummino, Peter J.</au><au>Caruso, Anthony</au><au>Uria-Nickelsen, Maria</au><au>Mills, Debra M.</au><au>Ives, Cameron</au><au>Gibson, Rene</au><au>Merberg, David</au><au>Mills, Scott D.</au><au>Jiang, Qin</au><au>Taylor, Diane E.</au><au>Vovis, Gerald F.</au><au>Trust, Trevor J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1999-01-14</date><risdate>1999</risdate><volume>397</volume><issue>6715</issue><spage>176</spage><epage>180</epage><pages>176-180</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Helicobacter pylori
, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma
1
. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host
2
,
3
and to participate in the lifelong chronicity of infection
4
. Here we compare the complete genomic sequences of two unrelated
H. pylori
isolates. This is, to our knowledge, the first such genomic comparison.
H. pylori
was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>9923682</pmid><doi>10.1038/16495</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1999-01, Vol.397 (6715), p.176-180 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_807268588 |
| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | Bacteria Bacteriology Biological and medical sciences Digestive system Disease Duodenal Ulcer - microbiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genetic diversity Genetics Genome, Bacterial Genomics Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - classification Helicobacter pylori - genetics Humanities and Social Sciences Humans letter Lymphoma Microbiology Molecular Sequence Data multidisciplinary Pathogens Science Science (multidisciplinary) Sequence Alignment Sequence Analysis, DNA Species Specificity |
| title | Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T22%3A52%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genomic-sequence%20comparison%20of%20two%20unrelated%20isolates%20of%20the%20human%20gastric%20pathogen%20Helicobacter%20pylori&rft.jtitle=Nature%20(London)&rft.au=Alm,%20Richard%20A.&rft.date=1999-01-14&rft.volume=397&rft.issue=6715&rft.spage=176&rft.epage=180&rft.pages=176-180&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/16495&rft_dat=%3Cproquest_cross%3E807268588%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204491563&rft_id=info:pmid/9923682&rfr_iscdi=true |